skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Zero-mode waveguides

Abstract

The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Cornell Univ., Ithaca, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176124
Patent Number(s):
7181122
Application Number:
11/313,971
Assignee:
Cornell Research Foundation, Inc. (Ithaca, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Resource Type:
Patent
Resource Relation:
Patent File Date: 2005 Dec 20
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 59 BASIC BIOLOGICAL SCIENCES; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS

Citation Formats

Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., and Webb, Watt W.. Zero-mode waveguides. United States: N. p., 2007. Web.
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., & Webb, Watt W.. Zero-mode waveguides. United States.
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., and Webb, Watt W.. Tue . "Zero-mode waveguides". United States. https://www.osti.gov/servlets/purl/1176124.
@article{osti_1176124,
title = {Zero-mode waveguides},
author = {Levene, Michael J. and Korlach, Jonas and Turner, Stephen W. and Craighead, Harold G. and Webb, Watt W.},
abstractNote = {The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {2}
}

Patent:

Save / Share:

Works referenced in this record:

Subwavelength surface-relief gratings fabricated by microcontact printing of self-assembled monolayers
journal, January 2001


Fluorescence Spectroscopy of Single Biomolecules
journal, March 1999


Two-Photon Fluorescence Coincidence Analysis: Rapid Measurements of Enzyme Kinetics
journal, September 2002


Dual-color fluorescence cross-correlation spectroscopy for multicomponent diffusional analysis in solution
journal, April 1997


Highly efficient single molecule detection in microstructures
journal, April 2001


Fabrication of microcapillaries and waveguides for single-molecule detection
conference, March 1998


Nanoelectromechanical Systems
journal, November 2000


Fabrication of a Configurable, Single-Use Microfluidic Device
journal, December 2001