Zero-mode waveguides
Abstract
The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.
- Inventors:
- Issue Date:
- Research Org.:
- Cornell Univ., Ithaca, NY (United States)
- Sponsoring Org.:
- USDOE; National Science Foundation (NSF); National Institutes of Health (NIH)
- OSTI Identifier:
- 1176124
- Patent Number(s):
- 7181122
- Application Number:
- 11/313,971
- Assignee:
- Cornell Research Foundation, Inc. (Ithaca, NY)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- 066898-0003891; BIR-8800278; P412RR04224-11
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2005 Dec 20
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION; 59 BASIC BIOLOGICAL SCIENCES; 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS
Citation Formats
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., and Webb, Watt W. Zero-mode waveguides. United States: N. p., 2007.
Web.
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., & Webb, Watt W. Zero-mode waveguides. United States.
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., and Webb, Watt W. Tue .
"Zero-mode waveguides". United States. https://www.osti.gov/servlets/purl/1176124.
@article{osti_1176124,
title = {Zero-mode waveguides},
author = {Levene, Michael J. and Korlach, Jonas and Turner, Stephen W. and Craighead, Harold G. and Webb, Watt W.},
abstractNote = {The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {2}
}
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