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Title: Synthetic heparin-binding growth factor analogs

Abstract

The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain that binds a heparin-binding growth factor receptor, covalently bound to a hydrophobic linker, which is in turn covalently bound to a non-signaling peptide that includes a heparin-binding domain. The synthetic heparin-binding growth factor analogs are useful as soluble biologics or as surface coatings for medical devices.

Inventors:
; ; ;
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176079
Patent Number(s):
7166574
Application Number:
10/224,268
Assignee:
BioSurface Engineering Technologies, Inc. (Rockville, MD)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Pena, Louis A., Zamora, Paul, Lin, Xinhua, and Glass, John D.. Synthetic heparin-binding growth factor analogs. United States: N. p., 2007. Web.
Pena, Louis A., Zamora, Paul, Lin, Xinhua, & Glass, John D.. Synthetic heparin-binding growth factor analogs. United States.
Pena, Louis A., Zamora, Paul, Lin, Xinhua, and Glass, John D.. Tue . "Synthetic heparin-binding growth factor analogs". United States. https://www.osti.gov/servlets/purl/1176079.
@article{osti_1176079,
title = {Synthetic heparin-binding growth factor analogs},
author = {Pena, Louis A. and Zamora, Paul and Lin, Xinhua and Glass, John D.},
abstractNote = {The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain that binds a heparin-binding growth factor receptor, covalently bound to a hydrophobic linker, which is in turn covalently bound to a non-signaling peptide that includes a heparin-binding domain. The synthetic heparin-binding growth factor analogs are useful as soluble biologics or as surface coatings for medical devices.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {1}
}

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Works referenced in this record:

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