Synthetic heparin-binding growth factor analogs
Abstract
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain that binds a heparin-binding growth factor receptor, covalently bound to a hydrophobic linker, which is in turn covalently bound to a non-signaling peptide that includes a heparin-binding domain. The synthetic heparin-binding growth factor analogs are useful as soluble biologics or as surface coatings for medical devices.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1176079
- Patent Number(s):
- 7166574
- Application Number:
- 10/224,268
- Assignee:
- BioSurface Engineering Technologies, Inc. (Rockville, MD); Brookhaven National Laboratory (Upton, NY)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2002 Aug 20
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Pena, Louis A., Zamora, Paul, Lin, Xinhua, and Glass, John D. Synthetic heparin-binding growth factor analogs. United States: N. p., 2007.
Web.
Pena, Louis A., Zamora, Paul, Lin, Xinhua, & Glass, John D. Synthetic heparin-binding growth factor analogs. United States.
Pena, Louis A., Zamora, Paul, Lin, Xinhua, and Glass, John D. Tue .
"Synthetic heparin-binding growth factor analogs". United States. https://www.osti.gov/servlets/purl/1176079.
@article{osti_1176079,
title = {Synthetic heparin-binding growth factor analogs},
author = {Pena, Louis A. and Zamora, Paul and Lin, Xinhua and Glass, John D.},
abstractNote = {The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain that binds a heparin-binding growth factor receptor, covalently bound to a hydrophobic linker, which is in turn covalently bound to a non-signaling peptide that includes a heparin-binding domain. The synthetic heparin-binding growth factor analogs are useful as soluble biologics or as surface coatings for medical devices.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {1}
}
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