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Title: Contrast enhancing solution for use in confocal microscopy

Abstract

A method of optically detecting a tumor during surgery. The method includes imaging at least one test point defined on the tumor using a first optical imaging system to provide a first tumor image. The method further includes excising a first predetermined layer of the tumor for forming an in-vivo defect area. A predetermined contrast enhancing solution is disposed on the in-vivo defect area, which is adapted to interact with at least one cell anomaly, such as basal cell carcinoma, located on the in-vivo defect area for optically enhancing the cell anomaly. Thereafter the defect area can be optically imaged to provide a clear and bright representation of the cell anomaly to aid a surgeon while surgically removing the cell anomaly.

Inventors:
; ;
Issue Date:
Research Org.:
Massachusetts General Hospital, Boston, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175965
Patent Number(s):
7128894
Application Number:
10/607,630
Assignee:
The United States of America as represented by the United States Department of Energy (Washington, DC)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG02-91ER61228
Resource Type:
Patent
Resource Relation:
Patent File Date: 2003 Jun 27
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Tannous, Zeina, Torres, Abel, and Gonzalez, Salvador. Contrast enhancing solution for use in confocal microscopy. United States: N. p., 2006. Web.
Tannous, Zeina, Torres, Abel, & Gonzalez, Salvador. Contrast enhancing solution for use in confocal microscopy. United States.
Tannous, Zeina, Torres, Abel, and Gonzalez, Salvador. Tue . "Contrast enhancing solution for use in confocal microscopy". United States. https://www.osti.gov/servlets/purl/1175965.
@article{osti_1175965,
title = {Contrast enhancing solution for use in confocal microscopy},
author = {Tannous, Zeina and Torres, Abel and Gonzalez, Salvador},
abstractNote = {A method of optically detecting a tumor during surgery. The method includes imaging at least one test point defined on the tumor using a first optical imaging system to provide a first tumor image. The method further includes excising a first predetermined layer of the tumor for forming an in-vivo defect area. A predetermined contrast enhancing solution is disposed on the in-vivo defect area, which is adapted to interact with at least one cell anomaly, such as basal cell carcinoma, located on the in-vivo defect area for optically enhancing the cell anomaly. Thereafter the defect area can be optically imaged to provide a clear and bright representation of the cell anomaly to aid a surgeon while surgically removing the cell anomaly.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {10}
}

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Works referenced in this record:

In Vivo Confocal Scanning Laser Microscopy of Human Skin II: Advances in Instrumentation and Comparison With Histology11The authors have declared conflict of interest.
journal, September 1999