Functional nucleic acid probes and uses thereof
Abstract
The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.
- Inventors:
- Issue Date:
- Research Org.:
- Iowa State Univ., Ames, IA (United States); Ames Laboratory (AMES), Ames, IA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175921
- Patent Number(s):
- 7115369
- Application Number:
- 10/096,872
- Assignee:
- Iowa State University Research Foundation, Inc. (Ames, IA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- W-7405-ENG-82
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2002 Mar 14
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Nilsen-Hamilton, Marit. Functional nucleic acid probes and uses thereof. United States: N. p., 2006.
Web.
Nilsen-Hamilton, Marit. Functional nucleic acid probes and uses thereof. United States.
Nilsen-Hamilton, Marit. Tue .
"Functional nucleic acid probes and uses thereof". United States. https://www.osti.gov/servlets/purl/1175921.
@article{osti_1175921,
title = {Functional nucleic acid probes and uses thereof},
author = {Nilsen-Hamilton, Marit},
abstractNote = {The present invention provides functional nucleic acid probes, and methods of using functional nucleic acid probes, for binding a target to carry out a desired function. The probes have at least one functional nucleic acid, at least one regulating nucleic acid, and at least one attenuator. The functional nucleic acid is maintained in an inactive state by the attenuator and activated by the regulating nucleic acid only in the presence of a regulating nucleic acid target. In its activated state the functional nucleic acid can bind to its target to carry out a desired function, such as generating a signal, cleaving a nucleic acid, or catalyzing a reaction.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 03 00:00:00 EDT 2006},
month = {Tue Oct 03 00:00:00 EDT 2006}
}
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Works referenced in this record:
Multicolor molecular beacons for allele discrimination
journal, January 1998
- Tyagi, Sanjay; Bratu, Diana P.; Kramer, Fred Russell
- Nature Biotechnology, Vol. 16, Issue 1, p. 49-53
Adaptive Recognition by Nucleic Acid Aptamers
journal, February 2000
- Hermann, T.
- Science, Vol. 287, Issue 5454
An Allosteric Hammerhead Ribozyme
journal, February 1995
- Porta, Helena; Lizardi, Paul M.
- Nature Biotechnology, Vol. 13, Issue 2
Molecular Beacons: Probes that Fluoresce upon Hybridization
journal, March 1996
- Tyagi, Sanjay; Kramer, Fred Russell
- Nature Biotechnology, Vol. 14, Issue 3, p. 303-308
High speed memory behavior and reliability of an amorphous As2S3 film doped with Ag
journal, October 1980
- Hirose, Y.; Hirose, H.; Morisue, M.
- Physica Status Solidi (a), Vol. 61, Issue 2
Selexion
journal, December 1991
- Irvine, Doug; Tuerk, Craig; Gold, Larry
- Journal of Molecular Biology, Vol. 222, Issue 3
Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology
journal, January 2001
- Jenne, Andreas; Hartig, Jörg S.; Piganeau, Nicolas
- Nature Biotechnology, Vol. 19, Issue 1
Structure, recognition and discrimination in RNA aptamer complexes with cofactors, amino acids, drugs and aminoglycoside antibiotics
journal, March 2000
- Patel, Dinshaw J.; Suri, Asif K.
- Reviews in Molecular Biotechnology, Vol. 74, Issue 1
Aptamers as therapeutic and diagnostic agents
journal, March 2000
- Brody, Edward N.; Gold, Larry
- Reviews in Molecular Biotechnology, Vol. 74, Issue 1