Advanced synchronous luminescence imaging for chemical and medical diagnostics
Abstract
A diagnostic method and associated system includes the steps of exposing at least one sample location with excitation radiation through a single optical waveguide or a single optical waveguide bundle, wherein the sample emits emission radiation in response to the excitation radiation. The same single optical waveguide or the single optical waveguide bundle receives at least a portion of the emission radiation from the sample, thus providing co-registration of the excitation radiation and the emission radiation. The wavelength of the excitation radiation and emission radiation is synchronously scanned to produce a spectrum upon which an image can be formed. An increased emission signal is generated by the enhanced overlap of the excitation and emission focal volumes provided by co-registration of the excitation and emission signals thus increasing the sensitivity as well as decreasing the exposure time necessary to obtain an image.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175906
- Patent Number(s):
- 7103402
- Application Number:
- 10/677,703
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Vo-Dinh, Tuan. Advanced synchronous luminescence imaging for chemical and medical diagnostics. United States: N. p., 2006.
Web.
Vo-Dinh, Tuan. Advanced synchronous luminescence imaging for chemical and medical diagnostics. United States.
Vo-Dinh, Tuan. Tue .
"Advanced synchronous luminescence imaging for chemical and medical diagnostics". United States. https://www.osti.gov/servlets/purl/1175906.
@article{osti_1175906,
title = {Advanced synchronous luminescence imaging for chemical and medical diagnostics},
author = {Vo-Dinh, Tuan},
abstractNote = {A diagnostic method and associated system includes the steps of exposing at least one sample location with excitation radiation through a single optical waveguide or a single optical waveguide bundle, wherein the sample emits emission radiation in response to the excitation radiation. The same single optical waveguide or the single optical waveguide bundle receives at least a portion of the emission radiation from the sample, thus providing co-registration of the excitation radiation and the emission radiation. The wavelength of the excitation radiation and emission radiation is synchronously scanned to produce a spectrum upon which an image can be formed. An increased emission signal is generated by the enhanced overlap of the excitation and emission focal volumes provided by co-registration of the excitation and emission signals thus increasing the sensitivity as well as decreasing the exposure time necessary to obtain an image.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 05 00:00:00 EDT 2006},
month = {Tue Sep 05 00:00:00 EDT 2006}
}
Works referenced in this record:
Multicomponent analysis by synchronous luminescence spectrometry
journal, March 1978
- Vo-Dinh, Tuan
- Analytical Chemistry, Vol. 50, Issue 3
Diffraction tomographic imaging with photon density waves: an explicit solution
journal, January 1998
- Norton, Stephen J.; Vo-Dinh, Tuan
- Journal of the Optical Society of America A, Vol. 15, Issue 10
Synchronous Luminescence Spectroscopy: Methodology and Applicability
journal, September 1982
- Vo-Dinh, Tuan
- Applied Spectroscopy, Vol. 36, Issue 5
Laser-Induced Differential Fluorescence for Cancer Diagnosis without Biopsy
journal, January 1997
- Vo-Dinh, Tuan; Panjehpour, Masoud; Overholt, Bergein F.
- Applied Spectroscopy, Vol. 51, Issue 1
Fast Scanning Synchronous Luminescence Spectrometer Based on Acousto-Optic Tunable Filters
journal, November 1995
- Hueber, Dennis M.; Stevenson, Christopher L.; Vo-Dinh, Tuan
- Applied Spectroscopy, Vol. 49, Issue 11