Laser-induced breakdown spectroscopy for specimen analysis

Kumar, Akshaya; Yu-Yueh, Fang; Burgess, Shane C.; Singh, Jagdish P.

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Title: Laser-induced breakdown spectroscopy for specimen analysis

Abstract

The present invention is directed to an apparatus, a system and a method for detecting the presence or absence of trace elements in a biological sample using Laser-Induced Breakdown Spectroscopy. The trace elements are used to develop a signature profile which is analyzed directly or compared with the known profile of a standard. In one aspect of the invention, the apparatus, system and method are used to detect malignant cancer cells in vivo.

Inventors:: Kumar, Akshaya; Yu-Yueh, Fang; Burgess, Shane C.; Singh, Jagdish P.

Issue Date:: 2006-08-15

Research Org.:: Mississippi State Univ., Mississippi State, MS (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175874

Patent Number(s):: 7092087

Application Number:: 10/662,347

Assignee:: Mississippi State University (Mississippi State, MS)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

G - PHYSICS G01 - MEASURING G01J - MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
A61B5/0075 - {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
A61B5/0084 - {for introduction into the body, e.g. by catheters
A61B5/0091 - {for mammography}
A61B5/415 - {the glands, e.g. tonsils, adenoids or thymus}
A61B5/418 - {lymph vessels, ducts or nodes}
A61B5/4312 - {Breast evaluation or disorder diagnosis

G - PHYSICS G01 - MEASURING G01J - MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT
G01J3/02 - Details
G01J3/0218 - {using optical fibers}
G01J3/443 - Emission spectrometry

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N21/718 - {Laser microanalysis, i.e. with formation of sample plasma}

Show less

DOE Contract Number:: FC26-98FT40395

Resource Type:: Patent

Resource Relation:: Patent File Date: 2003 Sep 16

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Kumar, Akshaya, Yu-Yueh, Fang, Burgess, Shane C., and Singh, Jagdish P. Laser-induced breakdown spectroscopy for specimen analysis.  United States: N. p., 2006. 
        Web.

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                    Kumar, Akshaya, Yu-Yueh, Fang, Burgess, Shane C., & Singh, Jagdish P. Laser-induced breakdown spectroscopy for specimen analysis.  United States.

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                    Kumar, Akshaya, Yu-Yueh, Fang, Burgess, Shane C., and Singh, Jagdish P. Tue .  
        "Laser-induced breakdown spectroscopy for specimen analysis".  United States.  https://www.osti.gov/servlets/purl/1175874.

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@article{osti_1175874,

  title        = {Laser-induced breakdown spectroscopy for specimen analysis},

  author       = {Kumar, Akshaya and Yu-Yueh, Fang and Burgess, Shane C. and Singh, Jagdish P.},

  abstractNote = {The present invention is directed to an apparatus, a system and a method for detecting the presence or absence of trace elements in a biological sample using Laser-Induced Breakdown Spectroscopy. The trace elements are used to develop a signature profile which is analyzed directly or compared with the known profile of a standard. In one aspect of the invention, the apparatus, system and method are used to detect malignant cancer cells in vivo.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2006},

  month        = {8}

}

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Works referenced in this record:

Cancer Statistics, 2003
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Jemal, A.; Murray, T.; Samuels, A.
CA: A Cancer Journal for Clinicians, Vol. 53, Issue 1
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Laser-induced breakdown spectroscopy: a tool for real-time, in vitro and in vivo identification of carious teeth
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Samek, Ota; Telle, Helmut H.; Beddows, David CS
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Application of laser-induced breakdown spectroscopy to in situ analysis of liquid samples
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Characterization of malignant tissue cells by laser-induced breakdown spectroscopy
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Kumar, Akshaya; Yueh, Fang-Yu; Singh, Jagdish P.
Applied Optics, Vol. 43, Issue 28
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Fundamentals and Applications of Laser-Induced Breakdown Spectroscopy
journal, December 1997

Rusak, D. A.; Castle, B. C.; Smith, B. W.
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Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer
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Proteomics in Early Detection of Cancer
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Clinical Chemistry, Vol. 47, Issue 10
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Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment
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A Canine Model of Familial Mammary Gland Neoplasia
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Schafer, K. A.; Kelly, G.; Schrader, R.
Veterinary Pathology, Vol. 35, Issue 3
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Detection of Sodium and Potassium in Single Human Red Blood Cells by 193-nm Laser Ablative Sampling: A Feasibility Demonstration
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Analytical Chemistry, Vol. 72, Issue 1
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Laser-Induced Breakdown Spectroscopy, Elemental Analysis
book, September 2006

Yueh, Fang-Yu; Singh, Jagdish P.; Zhang, Hansheng
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Similar Records

Title: Laser-induced breakdown spectroscopy for specimen analysis

Abstract

Citation Formats

Cancer Statistics, 2003 journal, January 2003

Laser-induced breakdown spectroscopy: a tool for real-time, in vitro and in vivo identification of carious teeth journal, December 2001

Application of laser-induced breakdown spectroscopy to in situ analysis of liquid samples journal, August 2000

Characterization of malignant tissue cells by laser-induced breakdown spectroscopy journal, January 2004

Fundamentals and Applications of Laser-Induced Breakdown Spectroscopy journal, December 1997

Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer journal, January 2000

Proteomics in Early Detection of Cancer journal, October 2001

Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment journal, September 1990

Direct Acquisition of Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectra from Laser Capture Microdissected Tissues journal, September 2000

A Canine Model of Familial Mammary Gland Neoplasia journal, May 1998

Detection of Sodium and Potassium in Single Human Red Blood Cells by 193-nm Laser Ablative Sampling: A Feasibility Demonstration journal, January 2000

Laser-Induced Breakdown Spectroscopy, Elemental Analysis book, September 2006

Fast and noninvasive fluorescence imaging of biological tissues in vivo using a flying-spot scanner journal, January 2001

High temperature fiber optic laser-induced breakdown spectroscopy sensor for analysis of molten alloy constituents journal, October 2002

Investigation of trace elements in cancer kidney tissues by SRIXE and PIXE journal, April 1996

Assessing Protein Patterns in Disease Using Imaging Mass Spectrometry journal, April 2004

Canine Inflammatory Mammary Carcinoma: Histopathology, Immunohistochemistry and Clinical Implications of 21 Cases journal, March 2003

Quantitative Simultaneous Elemental Determinations in Alloys Using Laser-Induced Breakdown Spectroscopy (LIBS) in an Ultra-High Vacuum journal, January 1994

Cancer Statistics, 2003
journal, January 2003

Laser-induced breakdown spectroscopy: a tool for real-time, in vitro and in vivo identification of carious teeth
journal, December 2001

Application of laser-induced breakdown spectroscopy to in situ analysis of liquid samples
journal, August 2000

Characterization of malignant tissue cells by laser-induced breakdown spectroscopy
journal, January 2004

Fundamentals and Applications of Laser-Induced Breakdown Spectroscopy
journal, December 1997

Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer
journal, January 2000

Proteomics in Early Detection of Cancer
journal, October 2001

Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment
journal, September 1990

Direct Acquisition of Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectra from Laser Capture Microdissected Tissues
journal, September 2000

A Canine Model of Familial Mammary Gland Neoplasia
journal, May 1998

Detection of Sodium and Potassium in Single Human Red Blood Cells by 193-nm Laser Ablative Sampling: A Feasibility Demonstration
journal, January 2000

Laser-Induced Breakdown Spectroscopy, Elemental Analysis
book, September 2006

Fast and noninvasive fluorescence imaging of biological tissues in vivo using a flying-spot scanner
journal, January 2001

High temperature fiber optic laser-induced breakdown spectroscopy sensor for analysis of molten alloy constituents
journal, October 2002

Investigation of trace elements in cancer kidney tissues by SRIXE and PIXE
journal, April 1996

Assessing Protein Patterns in Disease Using Imaging Mass Spectrometry
journal, April 2004

Canine Inflammatory Mammary Carcinoma: Histopathology, Immunohistochemistry and Clinical Implications of 21 Cases
journal, March 2003

Quantitative Simultaneous Elemental Determinations in Alloys Using Laser-Induced Breakdown Spectroscopy (LIBS) in an Ultra-High Vacuum
journal, January 1994