Title: Laser-induced breakdown spectroscopy for specimen analysis

Abstract

The present invention is directed to an apparatus, a system and a method for detecting the presence or absence of trace elements in a biological sample using Laser-Induced Breakdown Spectroscopy. The trace elements are used to develop a signature profile which is analyzed directly or compared with the known profile of a standard. In one aspect of the invention, the apparatus, system and method are used to detect malignant cancer cells in vivo.

Inventors:

Kumar, Akshaya; Yu-Yueh, Fang; Burgess, Shane C.; Singh, Jagdish P.

Issue Date:

2006-08-15

Research Org.:

Mississippi State Univ., Mississippi State, MS (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1175874

Patent Number(s):

7092087

Application Number:

10/662,347

Assignee:

Mississippi State University (Mississippi State, MS)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

G - PHYSICS G01 - MEASURING G01J - MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B5/0075 - {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
A61B5/0084 - {for introduction into the body, e.g. by catheters
A61B5/0091 - {for mammography}
A61B5/415 - {the glands, e.g. tonsils, adenoids or thymus}
A61B5/418 - {lymph vessels, ducts or nodes}
A61B5/4312 - {Breast evaluation or disorder diagnosis

G - PHYSICS G01 - MEASURING G01J - MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT

G01J3/02 - Details
G01J3/0218 - {using optical fibers}
G01J3/443 - Emission spectrometry

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N21/718 - {Laser microanalysis, i.e. with formation of sample plasma}

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DOE Contract Number:  

FC26-98FT40395

Resource Type:

Patent

Resource Relation:

Patent File Date: 2003 Sep 16

Country of Publication:

United States

Language:

English

Subject:

47 OTHER INSTRUMENTATION