Antibody specific for a DNA repair protein

Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

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Title: Antibody specific for a DNA repair protein

Abstract

An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.

Inventors:: Petrini, John H.; Morgan, William Francis; Maser, Richard Scott; Carney, James Patrick

Issue Date:: 2006-07-11

Research Org.:: Wisconsin Alumni Research Foundation, Madison, WI (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175830

Patent Number(s):: 7074902

Application Number:: 10/044,447

Assignee:: Wisconsin Alumni Research Foundation

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K16/18 - against material from animals or humans

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DOE Contract Number:: 4459-011502

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Petrini, John H., Morgan, William Francis, Maser, Richard Scott, and Carney, James Patrick. Antibody specific for a DNA repair protein.  United States: N. p., 2006. 
        Web.

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                    Petrini, John H., Morgan, William Francis, Maser, Richard Scott, & Carney, James Patrick. Antibody specific for a DNA repair protein.  United States.

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                    Petrini, John H., Morgan, William Francis, Maser, Richard Scott, and Carney, James Patrick. Tue .  
        "Antibody specific for a DNA repair protein".  United States.  https://www.osti.gov/servlets/purl/1175830.

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@article{osti_1175830,

  title        = {Antibody specific for a DNA repair protein},

  author       = {Petrini, John H. and Morgan, William Francis and Maser, Richard Scott and Carney, James Patrick},

  abstractNote = {An isolated and purified DNA molecule encoding a DNA repair protein, p95, is provided, as is isolated and purified p95. Also provided are methods of detecting p95 and DNA encoding p95. The invention further provides p95 knock-out mice.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2006},

  month        = {7}

}

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Works referenced in this record:

Production of pharmaceutical proteins from transgenic animals
journal, May 1994

Houdebine, Louis-Marie
Journal of Biotechnology, Vol. 34, Issue 3
https://doi.org/10.1016/0168-1656(94)90062-0

Targeting the mouse genome: a compendium of knockouts (part I)
journal, June 1995

Brandon, E. P.; Idzerda, R. L.; McKnight, G. S.
Current Biology, Vol. 5, Issue 6
https://doi.org/10.1016/S0960-9822(95)00127-8

Knockout Mice
journal, April 1996

Majzoub, Joseph A.; Muglia, Louis J.
New England Journal of Medicine, Vol. 334, Issue 14
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Analysis of the 5′ Region ofPMS2Reveals Heterogeneous Transcripts and a Novel Overlapping Gene
journal, September 1995

Nicolaides, Nicholas C.; Kinzler, Kenneth W.; Vogelstein, Bert
Genomics, Vol. 29, Issue 2
https://doi.org/10.1006/geno.1995.9997

Transgenic and knock-out models for studying DNA repair
journal, January 1995

Allemand, I.
Biochimie, Vol. 77, Issue 10
https://doi.org/10.1016/0300-9084(96)88202-2

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
journal, April 2000

Lim, Dae-Sik; Kim, Seong-Tae; Xu, Bo
Nature, Vol. 404, Issue 6778
https://doi.org/10.1038/35007091

Monoclonal antibodies in cancer detection and therapy
journal, March 1993

Goldenberg, David M.
The American Journal of Medicine, Vol. 94, Issue 3
https://doi.org/10.1016/0002-9343(93)90062-T

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks.
journal, October 1997

Maser, R. S.; Monsen, K. J.; Nelms, B. E.
Molecular and Cellular Biology, Vol. 17, Issue 10
https://doi.org/10.1128/MCB.17.10.6087

Xpaknockout mice
journal, October 1996

de Vries, Annemieke; van Steeg, Harry
Seminars in Cancer Biology, Vol. 7, Issue 5
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Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair.
journal, September 1996

Dolganov, G. M.; Maser, R. S.; Novikov, A.
Molecular and Cellular Biology, Vol. 16, Issue 9
https://doi.org/10.1128/MCB.16.9.4832

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
journal, August 1997

Xiao, Y.
Nucleic Acids Research, Vol. 25, Issue 15
https://doi.org/10.1093/nar/25.15.2985

Targeting the mouse genome: a compendium of knockouts (part II)
journal, July 1995

Brandon, E. P.; Idzerda, R. L.; McKnight, G. S.
Current Biology, Vol. 5, Issue 7
https://doi.org/10.1016/S0960-9822(95)00152-7

Isolation and Characterization of the Human MRE11 Homologue
journal, September 1995

Petrini, John H. J.; Walsh, Mary E.; DiMare, Catherine
Genomics, Vol. 29, Issue 1
https://doi.org/10.1006/geno.1995.1217

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome
journal, May 1998

Varon, Raymonda; Vissinga, Christine; Platzer, Matthias
Cell, Vol. 93, Issue 3
https://doi.org/10.1016/S0092-8674(00)81174-5

Expression of RAD4 Gene of Saccharomyces cerevisiae That Can Be Propagated in Escherichia coli without Inactivation
journal, May 1993

Choi, I. S.; Kim, J. B.; Jeon, S. H.
Biochemical and Biophysical Research Communications, Vol. 193, Issue 1
https://doi.org/10.1006/bbrc.1993.1608

Gene therapy - promises, problems and prospects
journal, September 1997

Verma, Inder M.; Somia, Nikunj
Nature, Vol. 389, Issue 6648
https://doi.org/10.1038/38410

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Similar Records

Title: Antibody specific for a DNA repair protein

Abstract

Citation Formats

Production of pharmaceutical proteins from transgenic animals journal, May 1994

Targeting the mouse genome: a compendium of knockouts (part I) journal, June 1995

Knockout Mice journal, April 1996

Analysis of the 5′ Region ofPMS2Reveals Heterogeneous Transcripts and a Novel Overlapping Gene journal, September 1995

Transgenic and knock-out models for studying DNA repair journal, January 1995

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway journal, April 2000

Monoclonal antibodies in cancer detection and therapy journal, March 1993

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks. journal, October 1997

Xpaknockout mice journal, October 1996

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. journal, September 1996

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells journal, August 1997

Targeting the mouse genome: a compendium of knockouts (part II) journal, July 1995

Isolation and Characterization of the Human MRE11 Homologue journal, September 1995

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome journal, May 1998

Expression of RAD4 Gene of Saccharomyces cerevisiae That Can Be Propagated in Escherichia coli without Inactivation journal, May 1993

Gene therapy - promises, problems and prospects journal, September 1997

Production of pharmaceutical proteins from transgenic animals
journal, May 1994

Targeting the mouse genome: a compendium of knockouts (part I)
journal, June 1995

Knockout Mice
journal, April 1996

Analysis of the 5′ Region ofPMS2Reveals Heterogeneous Transcripts and a Novel Overlapping Gene
journal, September 1995

Transgenic and knock-out models for studying DNA repair
journal, January 1995

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
journal, April 2000

Monoclonal antibodies in cancer detection and therapy
journal, March 1993

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks.
journal, October 1997

Xpaknockout mice
journal, October 1996

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair.
journal, September 1996

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
journal, August 1997

Targeting the mouse genome: a compendium of knockouts (part II)
journal, July 1995

Isolation and Characterization of the Human MRE11 Homologue
journal, September 1995

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome
journal, May 1998

Expression of RAD4 Gene of Saccharomyces cerevisiae That Can Be Propagated in Escherichia coli without Inactivation
journal, May 1993

Gene therapy - promises, problems and prospects
journal, September 1997