Inhibitors of glycogen synthase 3 kinase
Abstract
Compounds of formula 1: ##STR00001## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0 3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.
- Inventors:
- Issue Date:
- Research Org.:
- 7 Healthy Communities Institute Corporation; 2 Clinical Computer Systems Incorporated; Chiron Corporation; 3 Pdicta Corporation; 8 Trade Technologies Inc.; 9 Insight Catastrophe Solutions, Llc; 6 Webshade Pty Limited; 0 Pokos Communications Corp; 1 Vaucher Aerospace Corporation; 5 Leica Biosystems Melbourne Pty Lt; 4 Terra Imaging
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175761
- Patent Number(s):
- 7053097
- Application Number:
- 09/707,548
- Assignee:
- 7 Healthy Communities Institute Corporation; 2 Clinical Computer Systems Incorporated; Chiron Corporation; 3 Pdicta Corporation; 8 Trade Technologies Inc.; 9 Insight Catastrophe Solutions, Llc; 6 Webshade Pty Limited; 0 Pokos Communications Corp; 1 Vaucher Aerospace Corporation; 5 Leica Biosystems Melbourne Pty Lt; 4 Terra Imaging
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- AC03-76SF00098
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Schultz, Peter, Ring, David B., Harrison, Stephen D., and Bray, Andrew M. Inhibitors of glycogen synthase 3 kinase. United States: N. p., 2006.
Web.
Schultz, Peter, Ring, David B., Harrison, Stephen D., & Bray, Andrew M. Inhibitors of glycogen synthase 3 kinase. United States.
Schultz, Peter, Ring, David B., Harrison, Stephen D., and Bray, Andrew M. Tue .
"Inhibitors of glycogen synthase 3 kinase". United States. https://www.osti.gov/servlets/purl/1175761.
@article{osti_1175761,
title = {Inhibitors of glycogen synthase 3 kinase},
author = {Schultz, Peter and Ring, David B. and Harrison, Stephen D. and Bray, Andrew M.},
abstractNote = {Compounds of formula 1: ##STR00001## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0 3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 30 00:00:00 EDT 2006},
month = {Tue May 30 00:00:00 EDT 2006}
}
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