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Title: Inhibitors of glycogen synthase 3 kinase

Abstract

Compounds of formula 1: ##STR00001## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0 3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.

Inventors:
; ; ;
Issue Date:
Research Org.:
7 Healthy Communities Institute Corporation; 2 Clinical Computer Systems Incorporated; Chiron Corporation; 3 Pdicta Corporation; 8 Trade Technologies Inc.; 9 Insight Catastrophe Solutions, Llc; 6 Webshade Pty Limited; 0 Pokos Communications Corp; 1 Vaucher Aerospace Corporation; 5 Leica Biosystems Melbourne Pty Lt; 4 Terra Imaging
Sponsoring Org.:
USDOE
OSTI Identifier:
1175761
Patent Number(s):
7053097
Application Number:
09/707,548
Assignee:
7 Healthy Communities Institute Corporation; 2 Clinical Computer Systems Incorporated; Chiron Corporation; 3 Pdicta Corporation; 8 Trade Technologies Inc.; 9 Insight Catastrophe Solutions, Llc; 6 Webshade Pty Limited; 0 Pokos Communications Corp; 1 Vaucher Aerospace Corporation; 5 Leica Biosystems Melbourne Pty Lt; 4 Terra Imaging
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
AC03-76SF00098
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Schultz, Peter, Ring, David B., Harrison, Stephen D., and Bray, Andrew M.. Inhibitors of glycogen synthase 3 kinase. United States: N. p., 2006. Web.
Schultz, Peter, Ring, David B., Harrison, Stephen D., & Bray, Andrew M.. Inhibitors of glycogen synthase 3 kinase. United States.
Schultz, Peter, Ring, David B., Harrison, Stephen D., and Bray, Andrew M.. Tue . "Inhibitors of glycogen synthase 3 kinase". United States. https://www.osti.gov/servlets/purl/1175761.
@article{osti_1175761,
title = {Inhibitors of glycogen synthase 3 kinase},
author = {Schultz, Peter and Ring, David B. and Harrison, Stephen D. and Bray, Andrew M.},
abstractNote = {Compounds of formula 1: ##STR00001## wherein R.sub.1 is alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, or heteroaralkyl, substituted with 0 3 substituents selected from lower alkyl, halo, hydroxy, lower alkoxy, amino, lower alkyl-amino, and nitro; R.sub.2 is hydroxy, amino, or lower alkoxy; R.sub.3 is H, lower alkyl, lower acyl, lower alkoxy-acyl, or amino-acyl; R.sub.4 is H or lower alkyl; and pharmaceutically acceptable salts and esters thereof; are effective inhibitors of GSK3.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {5}
}

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Works referenced in this record:

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