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Title: Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs

Abstract

Laser tissue welding can be achieved using tunable Cr.sup.4+ lasers, semiconductor lasers and fiber lasers, where the weld strength follows the absorption spectrum of water. The use of gelatin and esterified gelatin as solders in conjunction with laser inducted tissue welding impart much stronger tensile and torque strengths than albumin solders. Selected NIR wavelength from the above lasers can improve welding and avoid thermal injury to tissue when used alone or with gelatin and esterified gelatin solders. These discoveries can be used to enhance laser tissue welding of tissues such as skin, mucous, bone, blood vessel, nerve, brain, liver, pancreas, spleen, kidney, lung, bronchus, respiratory track, urinary tract, gastrointestinal tract, or gynecologic tract and as a sealant for pulmonary air leaks and fistulas such as intestinal, rectal and urinary fistulas.

Inventors:
; ; ;
Issue Date:
Research Org.:
The Research Foundation of The City University of New York, New York, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175717
Patent Number(s):
7033348
Application Number:
10/119,914
Assignee:
The Research Foundation of The City University of New York (New York, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
DOE Contract Number:  
FG02-98ER62560
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Alfano, Robert R., Tang, Jing, Evans, Jonathan M., and Ho, Peng Pei. Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs. United States: N. p., 2006. Web.
Alfano, Robert R., Tang, Jing, Evans, Jonathan M., & Ho, Peng Pei. Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs. United States.
Alfano, Robert R., Tang, Jing, Evans, Jonathan M., and Ho, Peng Pei. Tue . "Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs". United States. https://www.osti.gov/servlets/purl/1175717.
@article{osti_1175717,
title = {Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs},
author = {Alfano, Robert R. and Tang, Jing and Evans, Jonathan M. and Ho, Peng Pei},
abstractNote = {Laser tissue welding can be achieved using tunable Cr.sup.4+ lasers, semiconductor lasers and fiber lasers, where the weld strength follows the absorption spectrum of water. The use of gelatin and esterified gelatin as solders in conjunction with laser inducted tissue welding impart much stronger tensile and torque strengths than albumin solders. Selected NIR wavelength from the above lasers can improve welding and avoid thermal injury to tissue when used alone or with gelatin and esterified gelatin solders. These discoveries can be used to enhance laser tissue welding of tissues such as skin, mucous, bone, blood vessel, nerve, brain, liver, pancreas, spleen, kidney, lung, bronchus, respiratory track, urinary tract, gastrointestinal tract, or gynecologic tract and as a sealant for pulmonary air leaks and fistulas such as intestinal, rectal and urinary fistulas.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {4}
}

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Works referenced in this record:

Dye-enhanced laser tissue welding
journal, January 1989


Laser tissue welding: A comprehensive review of current and future
journal, January 1995


Myristoyl Gelatin as a Sealant for Dacron Vascular Prostheses
journal, April 1997


Conformational Changes and Some Functional Characteristics of Gelatin Esterified with Fatty Acid
journal, June 2001


Skin Closure with Dye-Enhanced Laser Welding and Fibrinogen
journal, January 1991


Tissue soldering by use of indocyanine green dye-enhanced fibrinogen with the near infrared diode laser
journal, May 1990


Laser activation of tissue sealant in hand-sewn canine esophageal closure
journal, April 1992