Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs
Abstract
Laser tissue welding can be achieved using tunable Cr.sup.4+ lasers, semiconductor lasers and fiber lasers, where the weld strength follows the absorption spectrum of water. The use of gelatin and esterified gelatin as solders in conjunction with laser inducted tissue welding impart much stronger tensile and torque strengths than albumin solders. Selected NIR wavelength from the above lasers can improve welding and avoid thermal injury to tissue when used alone or with gelatin and esterified gelatin solders. These discoveries can be used to enhance laser tissue welding of tissues such as skin, mucous, bone, blood vessel, nerve, brain, liver, pancreas, spleen, kidney, lung, bronchus, respiratory track, urinary tract, gastrointestinal tract, or gynecologic tract and as a sealant for pulmonary air leaks and fistulas such as intestinal, rectal and urinary fistulas.
- Inventors:
- Issue Date:
- Research Org.:
- The Research Foundation of The City University of New York, New York, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175717
- Patent Number(s):
- 7033348
- Application Number:
- 10/119,914
- Assignee:
- The Research Foundation of The City University of New York (New York, NY)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
- DOE Contract Number:
- FG02-98ER62560
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Alfano, Robert R., Tang, Jing, Evans, Jonathan M., and Ho, Peng Pei. Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs. United States: N. p., 2006.
Web.
Alfano, Robert R., Tang, Jing, Evans, Jonathan M., & Ho, Peng Pei. Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs. United States.
Alfano, Robert R., Tang, Jing, Evans, Jonathan M., and Ho, Peng Pei. Tue .
"Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs". United States. https://www.osti.gov/servlets/purl/1175717.
@article{osti_1175717,
title = {Gelatin based on Power-gel.TM. as solders for Cr.sup.4+laser tissue welding and sealing of lung air leak and fistulas in organs},
author = {Alfano, Robert R. and Tang, Jing and Evans, Jonathan M. and Ho, Peng Pei},
abstractNote = {Laser tissue welding can be achieved using tunable Cr.sup.4+ lasers, semiconductor lasers and fiber lasers, where the weld strength follows the absorption spectrum of water. The use of gelatin and esterified gelatin as solders in conjunction with laser inducted tissue welding impart much stronger tensile and torque strengths than albumin solders. Selected NIR wavelength from the above lasers can improve welding and avoid thermal injury to tissue when used alone or with gelatin and esterified gelatin solders. These discoveries can be used to enhance laser tissue welding of tissues such as skin, mucous, bone, blood vessel, nerve, brain, liver, pancreas, spleen, kidney, lung, bronchus, respiratory track, urinary tract, gastrointestinal tract, or gynecologic tract and as a sealant for pulmonary air leaks and fistulas such as intestinal, rectal and urinary fistulas.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {4}
}
Works referenced in this record:
Dye-enhanced laser tissue welding
journal, January 1989
- Chuck, Roy S.; Oz, Mehmet C.; Delohery, Thomas M.
- Lasers in Surgery and Medicine, Vol. 9, Issue 5
Reinforcement of Colonic Anastomoses With a Laser and Dye–Enhanced Fibrinogen
journal, November 1990
- Moazami, Nader
- Archives of Surgery, Vol. 125, Issue 11
Biological effects and cytotoxicity of the composite composed by tricalcium phosphate and glutaraldehyde cross-linked gelatin
journal, May 1998
- Lin, Feng-Huei; Yao, Chun-Hsu; Sun, Jui-Sheng
- Biomaterials, Vol. 19, Issue 10
Laser tissue welding: A comprehensive review of current and future
journal, January 1995
- Bass, Lawrence S.; Treat, Michael R.
- Lasers in Surgery and Medicine, Vol. 17, Issue 4
Myristoyl Gelatin as a Sealant for Dacron Vascular Prostheses
journal, April 1997
- Sasajima, Tadahiro; Inaba, Masashi; Azuma, Nobuyoshi
- Artificial Organs, Vol. 21, Issue 4
Conformational Changes and Some Functional Characteristics of Gelatin Esterified with Fatty Acid
journal, June 2001
- Djagny, Kodjo Boady; Wang, Zhang; Xu, Shiying
- Journal of Agricultural and Food Chemistry, Vol. 49, Issue 6
Skin Closure with Dye-Enhanced Laser Welding and Fibrinogen
journal, January 1991
- Wider, Todd M.; Libutti, Steven K.; Greenwald, Daniel P.
- Plastic and Reconstructive Surgery, Vol. 88, Issue 6
Tissue soldering by use of indocyanine green dye-enhanced fibrinogen with the near infrared diode laser
journal, May 1990
- Oz, Mehmet C.; Johnson, Jeffrey P.; Parangi, Sareh
- Journal of Vascular Surgery, Vol. 11, Issue 5
Laser activation of tissue sealant in hand-sewn canine esophageal closure
journal, April 1992
- Auteri, Joseph S.; Oz, Mehmet C.; Jeevanandam, Valluvan
- The Journal of Thoracic and Cardiovascular Surgery, Vol. 103, Issue 4