Method of treating tumors
Abstract
A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States); Merck Patent GmbH, Darmstadt (Germany)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175707
- Patent Number(s):
- 7029652
- Application Number:
- 10/208,931
- Assignee:
- The Regents of the University of California (Oakland, CA); Merck Patent GmbH (Darmstadt, DE)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FG01-00NE22944; FG03-84ER60233
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
DeNardo, Sally J., Burke, Patricia A., DeNardo, Gerald L., Goodman, Simon, Matzku, legal representative, Kerstin, and Matzku, Siegfried. Method of treating tumors. United States: N. p., 2006.
Web.
DeNardo, Sally J., Burke, Patricia A., DeNardo, Gerald L., Goodman, Simon, Matzku, legal representative, Kerstin, & Matzku, Siegfried. Method of treating tumors. United States.
DeNardo, Sally J., Burke, Patricia A., DeNardo, Gerald L., Goodman, Simon, Matzku, legal representative, Kerstin, and Matzku, Siegfried. Tue .
"Method of treating tumors". United States. https://www.osti.gov/servlets/purl/1175707.
@article{osti_1175707,
title = {Method of treating tumors},
author = {DeNardo, Sally J. and Burke, Patricia A. and DeNardo, Gerald L. and Goodman, Simon and Matzku, legal representative, Kerstin and Matzku, Siegfried},
abstractNote = {A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {4}
}
Works referenced in this record:
Synergy between an antiangiogenic integrin v antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases
journal, February 1999
- Lode, H. N.; Moehler, T.; Xiang, R.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 4
Combined modality radioimmunotherapy: Promise and peril
journal, February 2002
- Burke, Patricia A.; DeNardo, Sally J.; Miers, Laird A.
- Cancer, Vol. 94, Issue S4
Neovascular Targeting with Cyclic RGD Peptide (cRGDf-ACHA) to Enhance Delivery of Radioimmunotherapy
journal, February 2000
- DeNardo, Sally J.; Burke, Patricia A.; Leigh, Bryan R.
- Cancer Biotherapy and Radiopharmaceuticals, Vol. 15, Issue 1