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Title: Method of treating tumors

Abstract

A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States); Merck Patent GmbH, Darmstadt (Germany)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175707
Patent Number(s):
7029652
Application Number:
10/208,931
Assignee:
The Regents of the University of California (Oakland, CA); Merck Patent GmbH (Darmstadt, DE)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
FG01-00NE22944; FG03-84ER60233
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

DeNardo, Sally J., Burke, Patricia A., DeNardo, Gerald L., Goodman, Simon, Matzku, legal representative, Kerstin, and Matzku, Siegfried. Method of treating tumors. United States: N. p., 2006. Web.
DeNardo, Sally J., Burke, Patricia A., DeNardo, Gerald L., Goodman, Simon, Matzku, legal representative, Kerstin, & Matzku, Siegfried. Method of treating tumors. United States.
DeNardo, Sally J., Burke, Patricia A., DeNardo, Gerald L., Goodman, Simon, Matzku, legal representative, Kerstin, and Matzku, Siegfried. Tue . "Method of treating tumors". United States. https://www.osti.gov/servlets/purl/1175707.
@article{osti_1175707,
title = {Method of treating tumors},
author = {DeNardo, Sally J. and Burke, Patricia A. and DeNardo, Gerald L. and Goodman, Simon and Matzku, legal representative, Kerstin and Matzku, Siegfried},
abstractNote = {A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {4}
}

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Works referenced in this record:

Synergy between an antiangiogenic integrin  v antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases
journal, February 1999


Combined modality radioimmunotherapy: Promise and peril
journal, February 2002


Neovascular Targeting with Cyclic RGD Peptide (cRGDf-ACHA) to Enhance Delivery of Radioimmunotherapy
journal, February 2000