pH-sensitive methacrylic copolymers and the production thereof
Abstract
The present invention provides novel multi-functional methacrylic copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility under acidic conditions. The copolymers are constructed from tertiary amine methacrylates and poly(ethylene glycol) containing methacrylates. The copolymers are useful as gene vectors, pharmaceutical carriers, and in protein separation applications.
- Inventors:
- Issue Date:
- Research Org.:
- Iowa State Univ., Ames, IA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175647
- Patent Number(s):
- 6998456
- Application Number:
- 10/367,415
- Assignee:
- Iowa State University Research Foundation (Ames, IA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- DOE Contract Number:
- W-7405-ENG-82
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2003 Feb 14
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Mallapragada, Surya K., Anderson, Brian C., Bloom, Paul D., and Sheares Ashby, Valerie V. pH-sensitive methacrylic copolymers and the production thereof. United States: N. p., 2006.
Web.
Mallapragada, Surya K., Anderson, Brian C., Bloom, Paul D., & Sheares Ashby, Valerie V. pH-sensitive methacrylic copolymers and the production thereof. United States.
Mallapragada, Surya K., Anderson, Brian C., Bloom, Paul D., and Sheares Ashby, Valerie V. Tue .
"pH-sensitive methacrylic copolymers and the production thereof". United States. https://www.osti.gov/servlets/purl/1175647.
@article{osti_1175647,
title = {pH-sensitive methacrylic copolymers and the production thereof},
author = {Mallapragada, Surya K. and Anderson, Brian C. and Bloom, Paul D. and Sheares Ashby, Valerie V.},
abstractNote = {The present invention provides novel multi-functional methacrylic copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility under acidic conditions. The copolymers are constructed from tertiary amine methacrylates and poly(ethylene glycol) containing methacrylates. The copolymers are useful as gene vectors, pharmaceutical carriers, and in protein separation applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {2}
}
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