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Title: Carboranylporphyrins and uses thereof

Abstract

The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.

Inventors:
;
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175641
Patent Number(s):
6995260
Application Number:
10/848,741
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Wu, Haitao, and Miura, Michiko. Carboranylporphyrins and uses thereof. United States: N. p., 2006. Web.
Wu, Haitao, & Miura, Michiko. Carboranylporphyrins and uses thereof. United States.
Wu, Haitao, and Miura, Michiko. Tue . "Carboranylporphyrins and uses thereof". United States. https://www.osti.gov/servlets/purl/1175641.
@article{osti_1175641,
title = {Carboranylporphyrins and uses thereof},
author = {Wu, Haitao and Miura, Michiko},
abstractNote = {The present invention is directed to low toxicity boronated compounds and methods for their use in the treatment, visualization, and diagnosis of tumors. More specifically, the present invention is directed to low toxicity carborane-containing 5, 10, 15, 20-tetraphenylporphyrin compounds and methods for their use particularly in boron neutron capture therapy (BNCT) and photodynamic therapy (PDT) for the treatment of tumors of the brain, head and neck, and surrounding tissue. The invention is also directed to using these carborane-containing tetraphenyl porphyrin compounds to methods of tumor imaging and/or diagnosis such as MRI, SPECT, or PET.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2006},
month = {2}
}

Works referenced in this record:

19F NMR Spectra and Structures of Halogenated Porphyrins
journal, July 1995


Synthesis of carboranyl derivatives of deuteroporphyrin IX
journal, December 1999


A Carboranyl Porphyrin for Boron Neutron Capture Therapy of Brain Tumors
book, January 1989


In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer
journal, November 1999


A Straightforward Synthesis of 3,4-Difluoropyrrole
journal, August 1998


Porphyrin-mediated boron neutron capture therapy: evaluation of the reactions of skin and central nervous system
journal, January 2003


Synthesis of a porphyrin-labelled carboranyl phosphate diester: a potential new drug for boron neutron capture therapy of cancer
journal, July 2002


Evaluation of carborane-containing porphyrins as tumour targeting agents for boron neutron capture therapy.
journal, July 1998


Syntheses of carboncarbon linked carboranylated porphyrins for boron neutron capture therapy of cancer
journal, September 2000


Synthesis, dark toxicity and induction of in vitro DNA photodamage by a tetra(4-nido-carboranylphenyl)porphyrin
journal, November 2002


Biodistribution of Copper Carboranyltetraphenylporphyrins in Rodents Bearing an Isogeneic or Human Neoplasm
journal, January 2001