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Title: Reversible geling co-polymer and method of making

Abstract

The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum geling molecular weight cutoff and a therapeutic agent.

Inventors:
Issue Date:
Research Org.:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175593
Patent Number(s):
6979464
Application Number:
09/209,541
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Gutowska, Anna. Reversible geling co-polymer and method of making. United States: N. p., 2005. Web.
Gutowska, Anna. Reversible geling co-polymer and method of making. United States.
Gutowska, Anna. Tue . "Reversible geling co-polymer and method of making". United States. https://www.osti.gov/servlets/purl/1175593.
@article{osti_1175593,
title = {Reversible geling co-polymer and method of making},
author = {Gutowska, Anna},
abstractNote = {The present invention is a thereapeutic agent carrier having a thermally reversible gel or geling copolymer that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum geling molecular weight cutoff and a therapeutic agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Dec 27 00:00:00 EST 2005},
month = {Tue Dec 27 00:00:00 EST 2005}
}

Works referenced in this record:

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Conjugates of stimuli-responsive polymers and biomolecules: Random and site-specific conjugates of temperature-sensitive polymers and proteins
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Temperature- and pH- Sensitive Hydrogels for Controlled Release of Antithrombotic Agents
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A new temperature- and pH-responsive copolymer for possible use in protein conjugation
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Temperature dependence of swelling of crosslinked poly(N,N′-alkyl substituted acrylamides) in water
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Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase
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Thermally reversible polymer gels for biohybrid artificial pancreas
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“Intelligent” Polymers in Medicine and Biotechnology
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Environmentally Sensitive Polymers and Hydrogels
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Swelling equilibria for weakly ionizable, temperature-sensitive hydrogels
journal, March 1991


Immobilization and characterization of ?-galactosidase in thermally reversible hydrogel beads
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Biodegradable block copolymers as injectable drug-delivery systems
journal, August 1997


Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH
journal, January 1995


Temperature-modulated platelet and lymphocyte interactions with poly(N-isopropylacrylamide)-grafted surfaces
journal, January 1995