Nucleic acid encoding DS-CAM proteins and products related thereto
Abstract
In accordance with the present invention, there are provided Down Syndrome-Cell Adhesion Molecule (DS-CAM) proteins. Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention DS-CAM proteins can be employed in a variety of ways, for example, for the production of anti-DS-CAM antibodies thereto, in therapeutic compositions and methods employing such proteins and/or antibodies. DS-CAM proteins are also useful in bioassays to identify agonists and antagonists thereto.
- Inventors:
- Issue Date:
- Research Org.:
- Cedars Sinai Medical Center, Los Angeles, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175539
- Patent Number(s):
- 6960656
- Application Number:
- 08/956,991
- Assignee:
- Cedars Sinai Medical Center (Los Angeles, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- FG03-92ER61402
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Korenberg, Julie R. Nucleic acid encoding DS-CAM proteins and products related thereto. United States: N. p., 2005.
Web.
Korenberg, Julie R. Nucleic acid encoding DS-CAM proteins and products related thereto. United States.
Korenberg, Julie R. Tue .
"Nucleic acid encoding DS-CAM proteins and products related thereto". United States. https://www.osti.gov/servlets/purl/1175539.
@article{osti_1175539,
title = {Nucleic acid encoding DS-CAM proteins and products related thereto},
author = {Korenberg, Julie R.},
abstractNote = {In accordance with the present invention, there are provided Down Syndrome-Cell Adhesion Molecule (DS-CAM) proteins. Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention DS-CAM proteins can be employed in a variety of ways, for example, for the production of anti-DS-CAM antibodies thereto, in therapeutic compositions and methods employing such proteins and/or antibodies. DS-CAM proteins are also useful in bioassays to identify agonists and antagonists thereto.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {11}
}
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Works referenced in this record:
Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. III. CREB Is Necessary for Presynaptic Functional Plasticity
journal, October 1996
- Davis, Graeme W.; Schuster, Christoph M.; Goodman, Corey S.
- Neuron, Vol. 17, Issue 4
The DCC Gene: Structural Analysis and Mutations in Colorectal Carcinomas
journal, February 1994
- Cho, Kathleen R.; Oliner, Jonathan D.; Simons, Jonathan W.
- Genomics, Vol. 19, Issue 3
A mouse cdc25 homolog is differentially and developmentally expressed.
journal, April 1992
- Kakizuka, A.; Sebastian, B.; Borgmeyer, U.
- Genes & Development, Vol. 6, Issue 4
Genetic Dissection of Structural and Functional Components of Synaptic Plasticity. II. Fasciclin II Controls Presynaptic Structural Plasticity
journal, October 1996
- Schuster, Christoph M.; Davis, Graeme W.; Fetter, Richard D.
- Neuron, Vol. 17, Issue 4
Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor
journal, October 1996
- Keino-Masu, Kazuko; Masu, Masayuki; Hinck, Lindsay
- Cell, Vol. 87, Issue 2
TAG-1/Axonin-1 Is a High-affinity Ligand of Neurocan, Phosphacan/Protein-tyrosine Phosphatase-ζ/β, and N-CAM
journal, June 1996
- Milev, Peter; Maurel, Patrice; Häring, Monika
- Journal of Biological Chemistry, Vol. 271, Issue 26
Homophilic and heterophilic binding activities of Nr-CAM, a nervous system cell adhesion molecule.
journal, October 1992
- Mauro, V. P.; Krushel, L. A.; Cunningham, B. A.
- The Journal of Cell Biology, Vol. 119, Issue 1
Human cDNA mapping using a high-resolution R-banding technique and fluorescence in situ hybridization
journal, January 1995
- Korenberg, J. R.; Chen, X. -N.
- Cytogenetic and Genome Research, Vol. 69, Issue 3-4
The Molecular Biology of Axon Guidance
journal, November 1996
- Tessier-Lavigne, M.; Goodman, C. S.
- Science, Vol. 274, Issue 5290
A new bacteriophage P1–derived vector for the propagation of large human DNA fragments
journal, January 1994
- loannou, Panayiotis A.; Amemiya, Chris T.; Garnes, Jeffrey
- Nature Genetics, Vol. 6, Issue 1
Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor
journal, April 1994
- Taira, Eiichi; Takaha, Natsuki; Taniura, Hideo
- Neuron, Vol. 12, Issue 4
GENOMICS: The Babel of Bioinformatics
journal, October 2000
- Attwood, T. K.
- Science, Vol. 290, Issue 5491
Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectin
journal, August 1988
- Moos, Marion; Tacke, Roland; Scherer, Herta
- Nature, Vol. 334, Issue 6184
Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system
journal, October 1988
- Ranscht, B.
- The Journal of Cell Biology, Vol. 107, Issue 4
BIG-1: A new TAG-1/F3-related member of the immunoglobulin superfamily with neurite outgrowth-promoting activity
journal, August 1994
- Yoshihara, Yoshihiro; Kawasaki, Miwa; Tani, Akiko
- Neuron, Vol. 13, Issue 2
Mutation analysis of a Sandhoff disease patient in the Maronite community in Cyprus
journal, August 1994
- Hara, Yoji; Ioannou, Panos; Drousiotou, Anthi
- Human Genetics, Vol. 94, Issue 2
A high-fidelity physical map of human chromosome 21q in yeast artificial chromosomes.
journal, December 1995
- Korenberg, J. R.; Chen, X. N.; Mitchell, S.
- Genome Research, Vol. 5, Issue 5
From genes to protein structure and function: novel applications of computational approaches in the genomic era
journal, January 2000
- Skolnick, Jeffrey; Fetrow, Jacquelyn S.
- Trends in Biotechnology, Vol. 18, Issue 1, p. 34-39
Functional domain analysis of glass, a zinc-finger-containing transcription factor in Drosophila.
journal, July 1995
- O'Neill, E. M.; Ellis, M. C.; Rubin, G. M.
- Proceedings of the National Academy of Sciences, Vol. 92, Issue 14
Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28
journal, July 1997
- Metzler, William J.; Bajorath, Jürgen; Fenderson, William
- Nature Structural Biology, Vol. 4, Issue 7
Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3
journal, January 1995
- Yamakawa, Kazuhiro; Mitchell, Steve; Hubert, René
- Human Molecular Genetics, Vol. 4, Issue 4
Neuronal cell adhesion molecule contactin/F11 binds to tenascin via its immunoglobulin-like domains.
journal, October 1992
- Zisch, A. H.; D'Alessandri, L.; Ranscht, B.
- The Journal of Cell Biology, Vol. 119, Issue 1
Down syndrome phenotypes: the consequences of chromosomal imbalance.
journal, May 1994
- Korenberg, J. R.; Chen, X. N.; Schipper, R.
- Proceedings of the National Academy of Sciences, Vol. 91, Issue 11
A reappraisal of non-consensus mRNA splice sites
journal, January 1991
- Jackson, Lan J.
- Nucleic Acids Research, Vol. 19, Issue 14
YAC analysis and minimal tiling path construction for chromosome 21q
journal, November 1995
- Gardiner, Katheleen; Graw, Sharon; Ichikawa, Hitoshi
- Somatic Cell and Molecular Genetics, Vol. 21, Issue 6
A periodic tryptophan protein 2 gene homologue (PWP2H) in the candidate region of progressive myoclonus epilepsy on 21q22.3
journal, January 1996
- Yamakawa, K.; Gao, D. -Q.; Korenberg, J. R.
- Cytogenetic and Genome Research, Vol. 74, Issue 1-2
Characterization of a Highly Conserved Human Homolog to the Chicken Neural Cell Surface Protein Bravo/Nr-CAM That Maps to Chromosome Band 7q31
journal, August 1996
- Lane, Robert P.; Chen, Xiao-Ning; Yamakawa, Kazuhiro
- Genomics, Vol. 35, Issue 3
Identification of a chromosome 18q gene that is altered in colorectal cancers
journal, January 1990
- Fearon, E.; Cho, K.; Nigro, J.
- Science, Vol. 247, Issue 4938
Expression of Various NCAM Isoforms in Human Embryonic Muscles: Correlation with Myosin Heavy Chain Phenotypes
journal, January 1992
- Figarella-Branger, D.; Pellissier, J. F.; Bianco, N.
- Journal of Neuropathology & Experimental Neurology, Vol. 51, Issue 1
Cloning of a delta opioid receptor by functional expression
journal, December 1992
- Evans, C.; Keith, D.; Morrison, H.
- Science, Vol. 258, Issue 5090
Aberrant splicing of neural cell adhesion molecule L1 mRNA in a family with X–linked hydrocephalus
journal, October 1992
- Rosenthal, André; Jouet, Monique; Kenwrick, Susan
- Nature Genetics, Vol. 2, Issue 2
X–linked spastic paraplegia (SPG1), MASA syndrome and X–linked hydrocephalus result from mutations in the L1 gene
journal, July 1994
- Jouet, Monique; Rosenthal, André; Armstrong, Giles
- Nature Genetics, Vol. 7, Issue 3
Cell Adhesion Molecules: Implications for a Molecular Histology
journal, June 1991
- Edelman, Gerald M.; Crossin, Kathryn L.
- Annual Review of Biochemistry, Vol. 60, Issue 1
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing
journal, May 1987
- Cunningham, B.; Hemperly, J.; Murray, B.
- Science, Vol. 236, Issue 4803
BAC and PAC Contigs Covering 3.5 Mb of the Down Syndrome Congenital Heart Disease Region between D21S55 and MX1 on Chromosome 21
journal, April 1997
- Hubert, René S.; Mitchell, Steve; Chen, Xiao-Ning
- Genomics, Vol. 41, Issue 2
Factors regulating the expression and function of calcium-independent cell adhesion molecules
journal, October 1993
- Walsh, F.; Doherty, P.
- Current Opinion in Cell Biology, Vol. 5, Issue 5