Title: Attachment of second harmonic-active moiety to molecules for detection of molecules at interfaces

Abstract

This invention provides methods of detecting molecules at an interface, which comprise labeling the molecules with a second harmonic-active moiety and detecting the labeled molecules at the interface using a surface selective technique. The invention also provides methods for detecting a molecule in a medium and for determining the orientation of a molecular species within a planar surface using a second harmonic-active moiety and a surface selective technique.

Inventors:

Salafsky, Joshua S.; Eisenthal, Kenneth B.

Issue Date:

2005-10-11

Research Org.:

The Trustees of Columbia University in the City of New York, New York, NY (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1175520

Patent Number(s):

6953694

Application Number:

09/731,366

Assignee:

The Trustees of Columbia University in the City of New York (New York, NY)

Patent Classifications (CPCs):

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/5005 - {involving human or animal cells
G01N33/533 - with fluorescent label
G01N33/54373 - {involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings}
G01N33/583 - {with non-fluorescent dye label}

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Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

74 ATOMIC AND MOLECULAR PHYSICS