Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy

Miura, Michiko; Slatkin, Daniel N.

Title: Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy

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Abstract

The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

Inventors:: Miura, Michiko; Slatkin, Daniel N.

Issue Date:: 2005-10-04

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175518

Patent Number(s):: 6951640

Application Number:: 10/375,454

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K41/0038 - {Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
A61K31/409 - having four such rings, e.g. porphine derivatives, bilirubin, biliverdine

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00 - Antineoplastic agents

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K51/0485 - {Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D487/22 - in which the condensed system contains four or more hetero rings

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K41/0095 - {Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins}

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DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats


                    Miura, Michiko, and Slatkin, Daniel N. Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy.  United States: N. p., 2005. 
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                    Miura, Michiko, & Slatkin, Daniel N. Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy.  United States.

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                    Miura, Michiko, and Slatkin, Daniel N. Tue .  
        "Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy".  United States.  https://www.osti.gov/servlets/purl/1175518.

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@article{osti_1175518,

  title        = {Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy},

  author       = {Miura, Michiko and Slatkin, Daniel N.},

  abstractNote = {The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2005},

  month        = {10}

}

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