Prevention of addiction in pain management

Dewey, Stephen L.; Brodie, Jonathan D.; Ashby, Charles R.

Title: Prevention of addiction in pain management

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Abstract

The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in reducing or eliminating the addictive liability of the analgesic. The invention also includes a method for reducing or eliminating the addictive

Inventors:: Dewey, Stephen L.; Brodie, Jonathan D.; Ashby, Jr., Charles R.

Issue Date:: 2005-09-06

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175486

Patent Number(s):: 6939876

Application Number:: 10/124,660

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/485 - Morphinan derivatives, e.g. morphine, codeine

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/30 - for treating abuse or dependence
A61P29/00 - Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents
A61P25/36 - Opioid-abuse

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P43/00 - Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P39/02 - Antidotes
A61P25/04 - Centrally acting analgesics, e.g. opioids

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Prevention of addiction in pain management.  United States: N. p., 2005. 
        Web.

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                    Dewey, Stephen L., Brodie, Jonathan D., & Ashby, Jr., Charles R. Prevention of addiction in pain management.  United States.

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                    Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Tue .  
        "Prevention of addiction in pain management".  United States.  https://www.osti.gov/servlets/purl/1175486.

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@article{osti_1175486,

  title        = {Prevention of addiction in pain management},

  author       = {Dewey, Stephen L. and Brodie, Jonathan D. and Ashby, Jr., Charles R.},

  abstractNote = {The present invention provides a composition for treating pain. The composition includes a pharmaceutically acceptable analgesic and a GABAergic agent, such as gamma vinyl GABA, effective in reducing or eliminating the addictive liability of the analgesic. The invention also includes a method for reducing or eliminating the addictive},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2005},

  month        = {9}

}

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