skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes

Abstract

The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Cornell Univ., Ithaca, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175425
Patent Number(s):
6917726
Application Number:
10/259,268
Assignee:
Cornell Research Foundation, Inc. (Ithaca, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., and Webb, Watt W. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes. United States: N. p., 2005. Web.
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., & Webb, Watt W. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes. United States.
Levene, Michael J., Korlach, Jonas, Turner, Stephen W., Craighead, Harold G., and Webb, Watt W. Tue . "Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes". United States. https://www.osti.gov/servlets/purl/1175425.
@article{osti_1175425,
title = {Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes},
author = {Levene, Michael J. and Korlach, Jonas and Turner, Stephen W. and Craighead, Harold G. and Webb, Watt W.},
abstractNote = {The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally through the core of the zero-mode waveguide. The analyte is positioned in the core of the zero-mode waveguide and is then subjected, in the core of the zero-mode waveguide, to activating electromagnetic radiation of a frequency less than the cut-off frequency under conditions effective to permit analysis of the analyte in an effective observation volume which is more compact than if the analysis were carried out in the absence of the zero-mode waveguide.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {7}
}

Patent:

Save / Share:

Works referenced in this record:

Fluorescence Spectroscopy of Single Biomolecules
journal, March 1999


Two-Photon Fluorescence Coincidence Analysis: Rapid Measurements of Enzyme Kinetics
journal, September 2002


Dual-color fluorescence cross-correlation spectroscopy for multicomponent diffusional analysis in solution
journal, April 1997


Highly efficient single molecule detection in microstructures
journal, April 2001


Fabrication of a Configurable, Single-Use Microfluidic Device
journal, December 2001