Title: Biosensor compositions and methods of use

Abstract

Provided are pore-subunit polypeptides covalently linked to one or more sensing moieties, and uses of these modified polypeptides to detect and/or measure analytes or physical characteristics within a given sample.

Inventors:

Bayley, Hagan P.; Howorka, Stefan G.; Movileanu, Liviu

Issue Date:

2005-07-12

Research Org.:

Texas A And M University, College Station, TX (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1175421

Patent Number(s):

6916665

Application Number:

09/781,697

Assignee:

Texas A And M University (College Station, TX)

Patent Classifications (CPCs):

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/5438 - {Electrodes}

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S530/825 - Bacteria

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/531 - Production of immunochemical test materials
G01N33/92 - involving lipids, e.g. cholesterol {, lipoproteins, or their receptors

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6874 - involving nucleic acid arrays, e.g. sequencing by hybridisation
C12Q1/6837 - using probe arrays or probe chips
C12Q1/6816 - characterised by the detection means

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/31 - from Staphylococcus

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q2565/607 - being a sensor, e.g. electrode

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DOE Contract Number:  

FG0397ER20271

Resource Type:

Patent

Country of Publication:

United States

Language:

English