Treatment of addiction and addiction-related behavior using a composition of topiramate

Dewey, Stephen L.; Brodie, Jonathan D.; Ashby, Charles R.

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A - human necessities
A01 - agriculture
A21 - baking
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Title: Treatment of addiction and addiction-related behavior using a composition of topiramate

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Abstract

The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.

Inventors:: Dewey, Stephen L.; Brodie, Jonathan D.; Ashby, Jr., Charles R.

Issue Date:: 2005-06-14

Research Org.:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175391

Patent Number(s):: 6906099

Application Number:: 09/776,117

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/00 - Medicinal preparations containing organic active ingredients
A61K31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
A61K31/16 - Amides, e.g. hydroxamic acids
A61K31/165 - having aromatic rings, e.g. colchicine, atenolol, progabide
A61K31/19 - Carboxylic acids, e.g. valproic acid
A61K31/195 - having an amino group
A61K31/197 - the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K31/221 - with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K31/35 - having six-membered rings with one oxygen as the only ring hetero atom
A61K31/4535 - containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/30 - for treating abuse or dependence
A61P25/32 - Alcohol-abuse
A61P25/34 - Tobacco-abuse
A61P25/36 - Opioid-abuse

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DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

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                    Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior using a composition of topiramate.  United States: N. p., 2005. 
        Web.

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                    Dewey, Stephen L., Brodie, Jonathan D., & Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior using a composition of topiramate.  United States.

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                    Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Tue .  
        "Treatment of addiction and addiction-related behavior using a composition of topiramate".  United States.  https://www.osti.gov/servlets/purl/1175391.

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@article{osti_1175391,

  title        = {Treatment of addiction and addiction-related behavior using a composition of topiramate},

  author       = {Dewey, Stephen L. and Brodie, Jonathan D. and Ashby, Jr., Charles R.},

  abstractNote = {The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2005},

  month        = {6}

}

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Treatment of addiction and addiction-related behavior

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