Title: Coordinate cytokine regulatory sequences

Abstract

The present invention provides CNS sequences that regulate the cytokine gene expression, expression cassettes and vectors comprising or lacking the CNS sequences, host cells and non-human transgenic animals comprising the CNS sequences or lacking the CNS sequences. The present invention also provides methods for identifying compounds that modulate the functions of CNS sequences as well as methods for diagnosing defects in the CNS sequences of patients.

Inventors:

Frazer, Kelly A.; Rubin, Edward M.; Loots, Gabriela G.

Issue Date:

2005-05-10

Research Org.:

Univ. of California, Oakland, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1175352

Patent Number(s):

6891031

Application Number:

09/789,529

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY

A01K2217/05 - Animals comprising random inserted nucleic acids

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

C07K14/5406 - {IL-4}
C07K14/5437 - {IL-13}

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N15/85 - for animal cells
C12N2800/206 - of yeast origin, e.g. YAC, 2u
C12N2800/30 - Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
C12N2830/00 - Vector systems having a special element relevant for transcription
C12N2830/85 - mammalian

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DOE Contract Number:  

AC03-76SF0098

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES