Treatment of addiction and addiction-related behavior

Dewey, Stephen L.; Brodie, Jonathan D.; Ashby, Charles R.

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Title: Treatment of addiction and addiction-related behavior

Abstract

The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.

Inventors:: Dewey, Stephen L.; Brodie, Jonathan D.; Ashby, Jr., Charles R.

Issue Date:: 2005-05-10

Research Org.:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175351

Patent Number(s):: 6890951

Application Number:: 09/933,157

Assignee:: Brookhaven Science Associates LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/00 - Medicinal preparations containing organic active ingredients
A61K31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
A61K31/16 - Amides, e.g. hydroxamic acids
A61K31/165 - having aromatic rings, e.g. colchicine, atenolol, progabide
A61K31/19 - Carboxylic acids, e.g. valproic acid
A61K31/195 - having an amino group
A61K31/197 - the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K31/221 - with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K31/35 - having six-membered rings with one oxygen as the only ring hetero atom
A61K31/4535 - containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen

Show less

DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior.  United States: N. p., 2005. 
        Web.

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                    Dewey, Stephen L., Brodie, Jonathan D., & Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior.  United States.

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                    Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Tue .  
        "Treatment of addiction and addiction-related behavior".  United States.  https://www.osti.gov/servlets/purl/1175351.

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@article{osti_1175351,

  title        = {Treatment of addiction and addiction-related behavior},

  author       = {Dewey, Stephen L. and Brodie, Jonathan D. and Ashby, Jr., Charles R.},

  abstractNote = {The present invention relates to the use of a composition that increases central nervous system GABA levels in a mammal, for the treatment of addiction to drugs of abuse and modification of behavior associated with addiction to drugs of abuse in said mammal.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2005},

  month        = {5}

}

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Works referenced in this record:

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure
journal, June 1997

Roberts, D. C. S.; Andrews, Monique M.
Psychopharmacology, Vol. 131, Issue 3
https://doi.org/10.1007/s002130050293

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward
journal, May 1995

Lepore, Marino; Vorel, Stanislav R.; Lowinson, Joyce
Life Sciences, Vol. 56, Issue 23-24
https://doi.org/10.1016/0024-3205(95)00191-8

Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels
journal, April 1993

Dewey, Stephen L.; Smith, Gwenn S.; Logan, Jean
Synapse, Vol. 13, Issue 4
https://doi.org/10.1002/syn.890130407

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.
journal, December 1993

Dewey, S. L.; Smith, G. S.; Logan, J.
Proceedings of the National Academy of Sciences, Vol. 90, Issue 24
https://doi.org/10.1073/pnas.90.24.11816

Pharmacologic characterization of nicotine-induced conditioned place preference
journal, February 1985

Fudala, Paul J.; Teoh, K. W.; Iwamoto, Edgar T.
Pharmacology Biochemistry and Behavior, Vol. 22, Issue 2
https://doi.org/10.1016/0091-3057(85)90384-3

Vigabatrin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Epilepsy and Disorders of Motor Control
journal, January 1991

Grant, Susan M.; Heel, Rennie C.
Drugs, Vol. 41, Issue 6
https://doi.org/10.2165/00003495-199141060-00007

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders
journal, March 1995

Nisell, Magnus; Nomikos, George G.; Svensson, Torgny H.
Pharmacology & Toxicology, Vol. 76, Issue 3
https://doi.org/10.1111/j.1600-0773.1995.tb00123.x

Self-administration in rats allowed unlimited access to nicotine
journal, October 1997

Valentine, James D.; Hokanson, Jonathan S.; Matta, Shannon G.
Psychopharmacology, Vol. 133, Issue 3
https://doi.org/10.1007/s002130050405

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release
journal, December 1994

Nisell, Magnus; Nomikos, George G.; Svensson, Torgny H.
Pharmacology & Toxicology, Vol. 75, Issue 6
https://doi.org/10.1111/j.1600-0773.1994.tb00373.x

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
journal, June 1998

Sora, I.; Wichems, C.; Takahashi, N.
Proceedings of the National Academy of Sciences, Vol. 95, Issue 13
https://doi.org/10.1073/pnas.95.13.7699

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens
journal, September 1989

Damsma, Geert; Day, Jamie; Fibiger, Hans C.
European Journal of Pharmacology, Vol. 168, Issue 3
https://doi.org/10.1016/0014-2999(89)90798-X

Apparent absence of nicotine-induced conditioned place preference in rats
journal, May 1987

Clarke, P. B. S.; Fibiger, H. C.
Psychopharmacology, Vol. 92, Issue 1
https://doi.org/10.1007/BF00215484

Control of behavior by intravenous nicotine injections in human subjects
journal, December 1983

Henningfield, Jack E.; Goldberg, Steven R.
Pharmacology Biochemistry and Behavior, Vol. 19, Issue 6
https://doi.org/10.1016/0091-3057(83)90409-4

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs
book, January 1987

van der Kooy, Derek
Methods of Assessing the Reinforcing Properties of Abused Drugs
https://doi.org/10.1007/978-1-4612-4812-5_13

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine-Treated Rats
journal, April 1997

Marshall, David L.; Redfern, Peter H.; Wonnacott, Susan
Journal of Neurochemistry, Vol. 68, Issue 4
https://doi.org/10.1046/j.1471-4159.1997.68041511.x

Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
journal, January 1994

Nisell, Magnus; Nomikos, George G.; Svensson, Torgny H.
Synapse, Vol. 16, Issue 1
https://doi.org/10.1002/syn.890160105

Imaging endogenous dopamine competition with [11C]raclopride in the human brain
journal, April 1994

Volkow, Nora D.; Wang, Gene-Jack; Fowler, Joanna S.
Synapse, Vol. 16, Issue 4
https://doi.org/10.1002/syn.890160402

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
journal, July 1996

Pontieri, Francesco E.; Tanda, Gianluigi; Orzi, Francesco
Nature, Vol. 382, Issue 6588
https://doi.org/10.1038/382255a0

?-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE
journal, November 1977

Jung, M. J.; Lippert, B.; Metcalf, B. W.
Journal of Neurochemistry, Vol. 29, Issue 5
https://doi.org/10.1111/j.1471-4159.1977.tb10721.x

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.
journal, July 1988

Lacey, M. G.; Mercuri, N. B.; North, R. A.
The Journal of Physiology, Vol. 401, Issue 1
https://doi.org/10.1113/jphysiol.1988.sp017171

Treatment of Cocaine Abuse: Pharmacotherapy
book, September 2007

Kleber, Herbert D.
Ciba Foundation Symposium 166 ‐ Cocaine: Scientific and Social Dimensions: Cocaine: Scientific and Social Dimensions: Ciba Foundation Symposium 166
https://doi.org/10.1002/9780470514245.ch11

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
journal, June 1984

Chesselet, M. -F.
Neuroscience, Vol. 12, Issue 2
https://doi.org/10.1016/0306-4522(84)90058-7

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
journal, July 1988

Di Chiara, G.; Imperato, A.
Proceedings of the National Academy of Sciences, Vol. 85, Issue 14
https://doi.org/10.1073/pnas.85.14.5274

Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase
journal, February 1997

Sherif, Fathi M.; Tawati, Ahmed M.; Ahmed, Saleem S.
European Neuropsychopharmacology, Vol. 7, Issue 1
https://doi.org/10.1016/S0924-977X(96)00383-5

Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels
journal, January 1996

Buckland, Paul R.; Spurlock, Gillian; McGuffin, Peter
Molecular Brain Research, Vol. 35, Issue 1-2
https://doi.org/10.1016/0169-328X(95)00182-R

Cigarette smokers self-administer intravenous nicotine
journal, November 1983

Henningfield, Jack E.; Miyasato, Katsumasa; Jasinski, Donald R.
Pharmacology Biochemistry and Behavior, Vol. 19, Issue 5
https://doi.org/10.1016/0091-3057(83)90099-0

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography
journal, October 1992

Dewey, Sl; Smith, Gs; Logan, J.
The Journal of Neuroscience, Vol. 12, Issue 10
https://doi.org/10.1523/JNEUROSCI.12-10-03773.1992

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - ¹¹ C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
journal, September 1990

Logan, Jean; Fowler, Joanna S.; Volkow, Nora D.
Journal of Cerebral Blood Flow & Metabolism, Vol. 10, Issue 5
https://doi.org/10.1038/jcbfm.1990.127

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds
journal, October 1997

Kushner, Stephanie A.; Dewey, Stephen L.; Kornetsky, C.
Psychopharmacology, Vol. 133, Issue 4
https://doi.org/10.1007/s002130050418

Pharmacological treatment of tobacco dependence
journal, May 1988

Jarvik, Murray E.; Henningfield, Jack E.
Pharmacology Biochemistry and Behavior, Vol. 30, Issue 1
https://doi.org/10.1016/0091-3057(88)90456-X

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
journal, December 1986

Imperato, Assunta; Mulas, Angelina; Di Chiara, Gaetano
European Journal of Pharmacology, Vol. 132, Issue 2-3
https://doi.org/10.1016/0014-2999(86)90629-1

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen
journal, December 1990

Brazell, M.; Mitchell, S.; Joseph, M.
Neuropharmacology, Vol. 29, Issue 12
https://doi.org/10.1016/0028-3908(90)90042-P

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation
journal, October 1997

Hurt, Richard D.; Sachs, David P. L.; Glover, Elbert D.
New England Journal of Medicine, Vol. 337, Issue 17
https://doi.org/10.1056/NEJM199710233371703

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats
journal, October 1996

Roberts, D.
Neuropsychopharmacology, Vol. 15, Issue 4
https://doi.org/10.1016/0893-133X(96)00002-4

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Similar Records

Title: Treatment of addiction and addiction-related behavior

Abstract

Citation Formats

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure journal, June 1997

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward journal, May 1995

Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels journal, April 1993

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects. journal, December 1993

Pharmacologic characterization of nicotine-induced conditioned place preference journal, February 1985

Vigabatrin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Epilepsy and Disorders of Motor Control journal, January 1991

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders journal, March 1995

Self-administration in rats allowed unlimited access to nicotine journal, October 1997

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release journal, December 1994

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice journal, June 1998

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens journal, September 1989

Apparent absence of nicotine-induced conditioned place preference in rats journal, May 1987

Control of behavior by intravenous nicotine injections in human subjects journal, December 1983

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs book, January 1987

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine-Treated Rats journal, April 1997

Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area journal, January 1994

Imaging endogenous dopamine competition with [11C]raclopride in the human brain journal, April 1994

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs journal, July 1996

?-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE journal, November 1977

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. journal, July 1988

Treatment of Cocaine Abuse: Pharmacotherapy book, September 2007

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis journal, June 1984

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. journal, July 1988

Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase journal, February 1997

Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels journal, January 1996

Cigarette smokers self-administer intravenous nicotine journal, November 1983

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography journal, October 1992

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - 11 C-Methyl]-(−)-Cocaine PET Studies in Human Subjects journal, September 1990

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds journal, October 1997

Pharmacological treatment of tobacco dependence journal, May 1988

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats journal, December 1986

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen journal, December 1990

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation journal, October 1997

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats journal, October 1996

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure
journal, June 1997

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward
journal, May 1995

Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels
journal, April 1993

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.
journal, December 1993

Pharmacologic characterization of nicotine-induced conditioned place preference
journal, February 1985

Vigabatrin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Epilepsy and Disorders of Motor Control
journal, January 1991

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders
journal, March 1995

Self-administration in rats allowed unlimited access to nicotine
journal, October 1997

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release
journal, December 1994

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
journal, June 1998

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens
journal, September 1989

Apparent absence of nicotine-induced conditioned place preference in rats
journal, May 1987

Control of behavior by intravenous nicotine injections in human subjects
journal, December 1983

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs
book, January 1987

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine-Treated Rats
journal, April 1997

Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
journal, January 1994

Imaging endogenous dopamine competition with [11C]raclopride in the human brain
journal, April 1994

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
journal, July 1996

?-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE
journal, November 1977

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.
journal, July 1988

Treatment of Cocaine Abuse: Pharmacotherapy
book, September 2007

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
journal, June 1984

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
journal, July 1988

Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase
journal, February 1997

Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels
journal, January 1996

Cigarette smokers self-administer intravenous nicotine
journal, November 1983

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography
journal, October 1992

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - ¹¹ C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
journal, September 1990

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds
journal, October 1997

Pharmacological treatment of tobacco dependence
journal, May 1988

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
journal, December 1986

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen
journal, December 1990

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation
journal, October 1997

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats
journal, October 1996