Method of staining target interphase chromosomal DNA

Gray, Joe W.; Pinkel, Daniel

Title: Method of staining target interphase chromosomal DNA

Inventors:: Gray, Joe W.; Pinkel, Daniel

Issue Date:: 2005-03-29

Research Org.:: The Regents of the Univ. of California, Oakland, CA (United States); Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175295

Patent Number(s):: 6872817

Assignee:: The Regents of the Univ. of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6853 - using modified primers or templates
C12Q1/6879 - for sex determination
C12Q1/6886 - for cancer
C12Q2563/107 - fluorescence
C12Q1/6811 - Selection methods for production or design of target specific oligonucleotides or binding molecules
C12Q2600/156 - Polymorphic or mutational markers
C12Q2563/131 - the label being a member of a cognate binding pair, i.e. extends to antibodies, haptens, avidin
C12Q2525/151 - repeat or repeated sequences, e.g. VNTR, microsatellite, concatemer
C12Q1/6841 - In situ hybridisation

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DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

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                    Gray, Joe W., and Pinkel, Daniel. Method of staining target interphase chromosomal DNA.  United States: N. p., 2005. 
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                    Gray, Joe W., & Pinkel, Daniel. Method of staining target interphase chromosomal DNA.  United States.

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                    Gray, Joe W., and Pinkel, Daniel. Tue .  
        "Method of staining target interphase chromosomal DNA".  United States.  https://www.osti.gov/servlets/purl/1175295.

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@article{osti_1175295,

  title        = {Method of staining target interphase chromosomal DNA},

  author       = {Gray, Joe W. and Pinkel, Daniel},

  abstractNote = {},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2005},

  month        = {3}

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https://doi.org/10.1016/0165-4608(85)90224-9

Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.
journal, November 1983

Ardeshir, F.; Giulotto, E.; Zieg, J.
Molecular and Cellular Biology, Vol. 3, Issue 11
https://doi.org/10.1128/MCB.3.11.2076

Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
journal, October 1992

Kallioniemi, A.; Kallioniemi, O.; Sudar, D.
Science, Vol. 258, Issue 5083
https://doi.org/10.1126/science.1359641

Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy.
journal, February 1992

Ried, T.; Baldini, A.; Rand, T. C.
Proceedings of the National Academy of Sciences, Vol. 89, Issue 4
https://doi.org/10.1073/pnas.89.4.1388

Detection of viral genomes in cultured cells and paraffin-embedded tissue sections using biotin-labeled hybridization probes
journal, April 1983

Brigati, David J.; Myerson, David; Leary, Jeffry J.
Virology, Vol. 126, Issue 1
https://doi.org/10.1016/0042-6822(83)90460-9

Detection of two viral genomes in single cells by double-label hybridization in situ and color microradioautography
journal, January 1985

Haase, A.; Walker, D.; Stowring, L.
Science, Vol. 227, Issue 4683
https://doi.org/10.1126/science.2981430

Assignment of the structural gene coding for albumin to human chromosome 4
journal, January 1982

Kao, Fa-Ten; Hawkins, J. W.; Law, Martha Liao
Human Genetics, Vol. 62, Issue 4
https://doi.org/10.1007/BF00304551

Specific staining of human chromosomes in Chinese hamster x man hybrid cell lines demonstrates interphase chromosome territories
journal, December 1985

Schardin, Margit; Cremer, T.; Hager, H. D.
Human Genetics, Vol. 71, Issue 4
https://doi.org/10.1007/BF00388452

Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells
journal, December 1990

Smith, Kathleen A.; Gorman, Patricia A.; Stark, Mary B.
Cell, Vol. 63, Issue 6
https://doi.org/10.1016/0092-8674(90)90417-D

Clinical Applications of DNA Probes in the Diagnosis of Genetic Diseases
journal, January 1987

Legrys, Vicky A.; Leinbach, Susan S.; Silverman, Lawrence Mark
CRC Critical Reviews in Clinical Laboratory Sciences, Vol. 25, Issue 4
https://doi.org/10.3109/10408368709105885

Localization of a unique gene by direct hybridization in situ.
journal, June 1981

Gerhard, D. S.; Kawasaki, E. S.; Bancroft, F. C.
Proceedings of the National Academy of Sciences, Vol. 78, Issue 6
https://doi.org/10.1073/pnas.78.6.3755

Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes
journal, February 1984

Cox, Kathleen H.; DeLeon, Donna V.; Angerer, Lynne M.
Developmental Biology, Vol. 101, Issue 2
https://doi.org/10.1016/0012-1606(84)90162-3

Individual interphase chromosome domains revealed by in situ hybridization
journal, December 1985

Manuelidis, Laura
Human Genetics, Vol. 71, Issue 4
https://doi.org/10.1007/BF00388453

Quantitation of in situ hybridization of ribosomal ribonucleic acids to human diploid cells
journal, October 1980

Cot�, Babette D.; Uhlenbeck, Olke C.; Steffensen, Dale M.
Chromosoma, Vol. 80, Issue 3
https://doi.org/10.1007/BF00292689

Organization and chromosomal specificity of autosomal homologs of human Y chromosome repeated DNA
journal, January 1985

Burk, Robert D.; Szabo, Paul; O'Brien, Steve
Chromosoma, Vol. 92, Issue 3
https://doi.org/10.1007/BF00348698

A polymorphic locus on the long arm of chromosome 20 defined by two probes from a single cosmid
journal, August 1986

Litt, M.; Sheehy, R.; Bruns, G. A.
Human Genetics, Vol. 73, Issue 4
https://doi.org/10.1007/BF00279097

Cytogenetic Analysis by In Situ Hybridization with Fluorescently Labeled Nucleic Acid Probes
journal, January 1986

Pinkel, D.; Gray, J. W.; Trask, B.
Cold Spring Harbor Symposia on Quantitative Biology, Vol. 51, Issue 0
https://doi.org/10.1101/SQB.1986.051.01.018

A new era in mammalian gene mapping: somatic cell genetics and recombinant DNA methodologies
journal, November 1981

Ruddle, F. H.
Nature, Vol. 294, Issue 5837
https://doi.org/10.1038/294115a0

2-Acetylaminofluorene-modified probes for the indirect hybridocytochemical detection of specific nucleic acid sequences
journal, July 1984

Landegent, J. E.; De Wal, N. Jansen In; Baan, R. A.
Experimental Cell Research, Vol. 153, Issue 1
https://doi.org/10.1016/0014-4827(84)90448-8

A highly polymorphic locus in human DNA revealed by cosmid-derived probes.
journal, September 1985

Litt, M.; White, R. L.
Proceedings of the National Academy of Sciences, Vol. 82, Issue 18
https://doi.org/10.1073/pnas.82.18.6206

Biotin and fluorescent labeling of RNA using T4 RNA ligase
journal, January 1983

Richardson, Ross W.; Gumport, Richard I.
Nucleic Acids Research, Vol. 11, Issue 18
https://doi.org/10.1093/nar/11.18.6167

High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones
journal, January 1990

Lichter, P.; Tang, C.; Call, K.
Science, Vol. 247, Issue 4938
https://doi.org/10.1126/science.2294592

Construction and characterization of genomic libraries from specific human chromosomes.
journal, May 1982

Krumlauf, R.; Jeanpierre, M.; Young, B. D.
Proceedings of the National Academy of Sciences, Vol. 79, Issue 9
https://doi.org/10.1073/pnas.79.9.2971

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Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in themore » « less
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Similar Records

Title: Method of staining target interphase chromosomal DNA

Citation Formats

Specific DNA sequence amplification in human neuroblastoma cells. journal, September 1983

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia. journal, March 1986

Isolation and characterization of a major tandem repeat family from the human X chromosome journal, January 1983

Detection of species specific chromosomes in somatic cell hybrids journal, November 1985

Partial purification and characterization of DNA from the human X chromosome. journal, December 1979

Preparative dual-beam sorting of the human Y chromosome and in situ hybridization of cloned DNA probes journal, November 1984

Detection of the Philadelphia chromosome in interphase nuclei journal, January 1990

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. journal, February 1991

Chromosomal localization of a single copy gene by in situ hybridization - human ? globin genes on the short arm of chromosome 11 journal, May 1981

Four restriction fragment length polymorphisms revealed by probes from a single cosmid map to human chromosome 12q journal, January 1986

Autoradiographic Detection of Molecular Hybrids between rRNA and DNA in Tissue Sections journal, March 1970

Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line journal, January 1988

The application of DNA recombinant technology to the analysis of the human genome and genetic disease journal, October 1981

Quantitative in situ hybridization of ribosomal RNA species to polytene chromosomes of Drosophila melanogaster journal, September 1977

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes journal, August 1984

What's new with hybridization in situ? journal, January 1982

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. journal, June 1992

Fetal cells in the blood of pregnant women: detection and enrichment by fluorescence-activated cell sorting. journal, March 1979

RNA-DNA Hybrids at the Cytological Level journal, August 1969

Localization of the human insulin gene to the distal end of the short arm of chromosome 11. journal, July 1981

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84 journal, December 1986

Microdissection and cloning of DNA from a specific region of Drosophila melanogaster polytene chromosomes journal, April 1981

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization journal, July 1981

Localization of the ribosomal genes in Caenorhabditis elegans chromosomes by in situ hybridization using biotin-labeled probes. journal, June 1984

Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization journal, August 1986

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. journal, May 1986

Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus. journal, December 1989

Organization and heterogeneity of sequences within a repeating unit of human Y chromosome deoxyribonucleic acid journal, July 1979

Isolation of unique sequence human X chromosomal deoxyribonucleic acid journal, May 1980

Mapping muscle protein genes by in situ hybridization using biotin-labeled probes. journal, October 1985

Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization journal, December 1987

A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library journal, December 1986

Detection of chromosome aberrations in interphase tumor nuclei by nonradioactive in situ hybridization journal, October 1989

Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes journal, June 1988

The proximity of DNA sequences in interphase cell nuclei is correlated to genomic distance and permits ordering of cosmids spanning 250 kilobase pairs journal, November 1989

Human chromosome-specific repetitive DNA sequences: novel markers for genetic analysis journal, October 1987

Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14 journal, May 1980

Chemically modified nucleic acids as immunodetectable probes in hybridization experiments. journal, June 1984

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes journal, November 1988

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries journal, November 1988

Screening lambdagt recombinant clones by hybridization to single plaques in situ journal, April 1977

Hereditary Renal-Cell Carcinoma Associated with a Chromosomal Translocation journal, September 1979

Formation and Detection of Rna-Dna Hybrid Molecules in Cytological Preparations journal, June 1969

Chromosomal and nuclear distribution of the HindIII 1.9-kb human DNA repeat segment journal, December 1984

Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. journal, April 1988

Different central nervous system cell types display distinct and nonrandom arrangements of satellite DNA sequences. journal, May 1984

Characterization of a cloned DNA sequence that is present at centromeres of all human autosomes and the X chromosome and shows polymorphic variation. journal, August 1984

Construction of fifteen human chromosome-specific DNA libraries from flow-purified chromosomes journal, January 1986

Differential distribution of long and short interspersed element sequences in the mouse genome: chromosome karyotyping by fluorescence in situ hybridization. journal, October 1990

Detection of amplified dna sequences in human tumor cell lines by fluorescence in situ hybridization journal, June 1992

A procedure for the isolation of deoxyribonucleic acid from micro-organisms journal, April 1961

Molecular hybridization under conditions of high stringency permits cloned DNA segments containing reiterated DNA sequences to be assigned to specific chromosomal locations. journal, January 1984

Fluorescence in situ hybridization with Alu and L1 polymerase chain reaction probes for rapid characterization of human chromosomes in hybrid cell lines. journal, September 1990

A new method for fluorescence microscopical localization of specific DNA sequences by in situ hybridization of fluorochrome-labelled RNA journal, August 1980

Genomic mismatch scanning: a new approach to genetic linkage mapping journal, May 1993

Report of the committee on structural chromosome changes in neoplasia journal, January 1989

Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8 journal, June 1990

General method for cloning amplified DNA by differential screening with genomic probes. journal, May 1982

A noninvasive method for determination of the sex and karyotype of the fetus from the maternal blood journal, August 1988

Direct carrier detection by in situ suppression hybridization with cosmid clones of the Duchenne/Becker muscular dystrophy locus journal, October 1990

The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit β-globin DNA journal, January 1981

Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes journal, March 1985

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. journal, October 1975

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. journal, December 1988

Rapid detection of human chromosome 21 aberrations by in situ hybridization. journal, December 1988

In situ hybridization and translocation breakpoint mapping journal, January 1985

Multiple sex chromosomes in Drosophila miranda: A system to study the degeneration of a chromosome journal, September 1982

Chemical synthesis of oligonucleotides containing a free sulphydryl group and subsequent attachment of thiol specific probes journal, January 1985

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors journal, August 1994

Analysis of a dispersed repetitive DNA sequence in isogenic lines of Drosophila journal, May 1981

Cytogenetics of the parthenogenetic grasshopper Warramaba virgo and its bisexual relatives: VII. Evidence from repeated DNA sequences for a dual origin of W. virgo journal, May 1981

Detection of structural and numerical abnormalities in metaphase spreads and interphase nuclei using in situ hybridization journal, September 1989

Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse journal, August 1984

Removal of repeated sequences from hybridisation probes journal, January 1985

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma journal, October 1986

Quantitative in situ hybridization reveals extent of sequence homology between related DNA sequences in Drosophila melanogaster journal, July 1981

Characterization of chromosomal anomalies in human breast cancer journal, October 1990

Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method. journal, November 1984

Specific DNA sequence amplification in human neuroblastoma cells.
journal, September 1983

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.
journal, March 1986

Isolation and characterization of a major tandem repeat family from the human X chromosome
journal, January 1983

Detection of species specific chromosomes in somatic cell hybrids
journal, November 1985

Partial purification and characterization of DNA from the human X chromosome.
journal, December 1979

Preparative dual-beam sorting of the human Y chromosome and in situ hybridization of cloned DNA probes
journal, November 1984

Detection of the Philadelphia chromosome in interphase nuclei
journal, January 1990

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration.
journal, February 1991

Chromosomal localization of a single copy gene by in situ hybridization - human ? globin genes on the short arm of chromosome 11
journal, May 1981

Four restriction fragment length polymorphisms revealed by probes from a single cosmid map to human chromosome 12q
journal, January 1986

Autoradiographic Detection of Molecular Hybrids between rRNA and DNA in Tissue Sections
journal, March 1970

Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line
journal, January 1988

The application of DNA recombinant technology to the analysis of the human genome and genetic disease
journal, October 1981

Quantitative in situ hybridization of ribosomal RNA species to polytene chromosomes of Drosophila melanogaster
journal, September 1977

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes
journal, August 1984

What's new with hybridization in situ?
journal, January 1982

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.
journal, June 1992

Fetal cells in the blood of pregnant women: detection and enrichment by fluorescence-activated cell sorting.
journal, March 1979

RNA-DNA Hybrids at the Cytological Level
journal, August 1969

Localization of the human insulin gene to the distal end of the short arm of chromosome 11.
journal, July 1981

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84
journal, December 1986

Microdissection and cloning of DNA from a specific region of Drosophila melanogaster polytene chromosomes
journal, April 1981

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization
journal, July 1981

Localization of the ribosomal genes in Caenorhabditis elegans chromosomes by in situ hybridization using biotin-labeled probes.
journal, June 1984

Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization
journal, August 1986

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.
journal, May 1986

Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus.
journal, December 1989

Organization and heterogeneity of sequences within a repeating unit of human Y chromosome deoxyribonucleic acid
journal, July 1979

Isolation of unique sequence human X chromosomal deoxyribonucleic acid
journal, May 1980

Mapping muscle protein genes by in situ hybridization using biotin-labeled probes.
journal, October 1985

Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization
journal, December 1987

A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library
journal, December 1986

Detection of chromosome aberrations in interphase tumor nuclei by nonradioactive in situ hybridization
journal, October 1989

Rapid interphase and metaphase assessment of specific chromosomal changes in neuroectodermal tumor cells by in situ hybridization with chemically modified DNA probes
journal, June 1988

The proximity of DNA sequences in interphase cell nuclei is correlated to genomic distance and permits ordering of cosmids spanning 250 kilobase pairs
journal, November 1989

Human chromosome-specific repetitive DNA sequences: novel markers for genetic analysis
journal, October 1987

Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14
journal, May 1980

Chemically modified nucleic acids as immunodetectable probes in hybridization experiments.
journal, June 1984

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes
journal, November 1988

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries
journal, November 1988

Screening lambdagt recombinant clones by hybridization to single plaques in situ
journal, April 1977

Hereditary Renal-Cell Carcinoma Associated with a Chromosomal Translocation
journal, September 1979

Formation and Detection of Rna-Dna Hybrid Molecules in Cytological Preparations
journal, June 1969

Chromosomal and nuclear distribution of the HindIII 1.9-kb human DNA repeat segment
journal, December 1984

Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants.
journal, April 1988

Different central nervous system cell types display distinct and nonrandom arrangements of satellite DNA sequences.
journal, May 1984

Characterization of a cloned DNA sequence that is present at centromeres of all human autosomes and the X chromosome and shows polymorphic variation.
journal, August 1984

Construction of fifteen human chromosome-specific DNA libraries from flow-purified chromosomes
journal, January 1986

Differential distribution of long and short interspersed element sequences in the mouse genome: chromosome karyotyping by fluorescence in situ hybridization.
journal, October 1990

Detection of amplified dna sequences in human tumor cell lines by fluorescence in situ hybridization
journal, June 1992

A procedure for the isolation of deoxyribonucleic acid from micro-organisms
journal, April 1961

Molecular hybridization under conditions of high stringency permits cloned DNA segments containing reiterated DNA sequences to be assigned to specific chromosomal locations.
journal, January 1984

Fluorescence in situ hybridization with Alu and L1 polymerase chain reaction probes for rapid characterization of human chromosomes in hybrid cell lines.
journal, September 1990

A new method for fluorescence microscopical localization of specific DNA sequences by in situ hybridization of fluorochrome-labelled RNA
journal, August 1980

Genomic mismatch scanning: a new approach to genetic linkage mapping
journal, May 1993

Report of the committee on structural chromosome changes in neoplasia
journal, January 1989

Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8
journal, June 1990

General method for cloning amplified DNA by differential screening with genomic probes.
journal, May 1982

A noninvasive method for determination of the sex and karyotype of the fetus from the maternal blood
journal, August 1988

Direct carrier detection by in situ suppression hybridization with cosmid clones of the Duchenne/Becker muscular dystrophy locus
journal, October 1990

The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit β-globin DNA
journal, January 1981

Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes
journal, March 1985

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene.
journal, October 1975

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.
journal, December 1988

Rapid detection of human chromosome 21 aberrations by in situ hybridization.
journal, December 1988

In situ hybridization and translocation breakpoint mapping
journal, January 1985

Multiple sex chromosomes in Drosophila miranda: A system to study the degeneration of a chromosome
journal, September 1982

Chemical synthesis of oligonucleotides containing a free sulphydryl group and subsequent attachment of thiol specific probes
journal, January 1985

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
journal, August 1994

Analysis of a dispersed repetitive DNA sequence in isogenic lines of Drosophila
journal, May 1981

Cytogenetics of the parthenogenetic grasshopper Warramaba virgo and its bisexual relatives: VII. Evidence from repeated DNA sequences for a dual origin of W. virgo
journal, May 1981

Detection of structural and numerical abnormalities in metaphase spreads and interphase nuclei using in situ hybridization
journal, September 1989

Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse
journal, August 1984

Removal of repeated sequences from hybridisation probes
journal, January 1985

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
journal, October 1986

Quantitative in situ hybridization reveals extent of sequence homology between related DNA sequences in Drosophila melanogaster
journal, July 1981

Characterization of chromosomal anomalies in human breast cancer
journal, October 1990

Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method.
journal, November 1984

Immunological method for mapping genes on Drosophila polytene chromosomes.
journal, July 1982

Direct nonradioactive in situ hybridization of somatic cell hybrid DNA to human lymphocyte chromosomes
journal, January 1990