Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders
Abstract
Disclosed are novel nucleic acid and peptide compositions comprising methythlioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and idenification tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.
- Inventors:
- Issue Date:
- Research Org.:
- Arch Development Corporation, Chicago, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175285
- Patent Number(s):
- 6870037
- Application Number:
- 08/674,311
- Assignee:
- Arch Development Corporation (Chicago, IL)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- FG02-86ER60408
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Olopade, Olufunmilayo I. Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders. United States: N. p., 2005.
Web.
Olopade, Olufunmilayo I. Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders. United States.
Olopade, Olufunmilayo I. Tue .
"Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders". United States. https://www.osti.gov/servlets/purl/1175285.
@article{osti_1175285,
title = {Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders},
author = {Olopade, Olufunmilayo I.},
abstractNote = {Disclosed are novel nucleic acid and peptide compositions comprising methythlioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and idenification tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {3}
}
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