Oncoprotein protein kinase

Karin, Michael; Hibi, Masahiko; Lin, Anning; Davis, Roger; Derijard, Benoit

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A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
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B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
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B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
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B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
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B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
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B82 - nanotechnology
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C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
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C10 - petroleum, gas or coke industries
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C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
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D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
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D10 - indexing scheme associated with sublasses of section d, relating to textiles
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F42 - ammunition
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G - physics
G01 - measuring
G02 - optics
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Y10 - technical subjects covered by former uspc

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Title: Oncoprotein protein kinase

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Inventors:: Karin, Michael; Hibi, Masahiko; Lin, Anning; Davis, Roger; Derijard, Benoit

Issue Date:: Tue Mar 08 00:00:00 EST 2005

Research Org.:: Univ. of California, Oakland, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175259

Patent Number(s):: 6863888

Application Number:: 09/861,097

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K16/40 - against enzymes

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N9/12 - transferring phosphorus containing groups, e.g. kinases
C12N9/1205 - {Phosphotransferases with an alcohol group as acceptor

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/485 - {involving kinase}
C12Q1/6897 - involving reporter genes operably linked to promoters

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N2333/9121 - with an alcohol group as acceptor
G01N2500/04 - Screening involving studying the effect of compounds C directly on molecule A

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S435/81 - Packaged device or kit
Y10S435/975 - Kit

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DOE Contract Number:: 86ER60429

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Karin, Michael, Hibi, Masahiko, Lin, Anning, Davis, Roger, and Derijard, Benoit. Oncoprotein protein kinase.  United States: N. p., 2005. 
        Web.

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                    Karin, Michael, Hibi, Masahiko, Lin, Anning, Davis, Roger, & Derijard, Benoit. Oncoprotein protein kinase.  United States.

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                    Karin, Michael, Hibi, Masahiko, Lin, Anning, Davis, Roger, and Derijard, Benoit. Tue .  
        "Oncoprotein protein kinase".  United States.  https://www.osti.gov/servlets/purl/1175259.

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@article{osti_1175259,

  title        = {Oncoprotein protein kinase},

  author       = {Karin, Michael and Hibi, Masahiko and Lin, Anning and Davis, Roger and Derijard, Benoit},

  abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Mar 08 00:00:00 EST 2005},

  month        = {Tue Mar 08 00:00:00 EST 2005}

}

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Works referenced in this record:

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
journal, July 2001

Han, Zuoning; Boyle, David L.; Chang, Lufen
Journal of Clinical Investigation, Vol. 108, Issue 1
https://doi.org/10.1172/JCI12466

Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase
journal, March 1988

Lee, C.; Wu, X.; Gibbs, R.
Science, Vol. 239, Issue 4845
https://doi.org/10.1126/science.3344434

Induction of protooncogene c-jun by serum growth factors.
journal, November 1988

Ryder, K.; Nathans, D.
Proceedings of the National Academy of Sciences, Vol. 85, Issue 22
https://doi.org/10.1073/pnas.85.22.8464

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.
journal, October 1994

Minden, A.; Lin, A.; Smeal, T.
Molecular and Cellular Biology, Vol. 14, Issue 10
https://doi.org/10.1128/MCB.14.10.6683

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
journal, November 1993

Hibi, M.; Lin, A.; Smeal, T.
Genes & Development, Vol. 7, Issue 11
https://doi.org/10.1101/gad.7.11.2135

A central role for JNK in obesity and insulin resistance
journal, November 2002

Hirosumi, Jiro; Tuncman, Gürol; Chang, Lufen
Nature, Vol. 420, Issue 6913
https://doi.org/10.1038/nature01137

Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
journal, December 1987

Bohmann, D.; Bos, T.; Admon, A.
Science, Vol. 238, Issue 4832
https://doi.org/10.1126/science.2825349

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
journal, May 1991

Boulton, Teri G.; Nye, Steven H.; Robbins, David J.
Cell, Vol. 65, Issue 4
https://doi.org/10.1016/0092-8674(91)90098-J

Parallel signal processing among mammalian MAPKs
journal, March 1995

Cano, Eva; Mahadevan, Louis C.
Trends in Biochemical Sciences, Vol. 20, Issue 3
https://doi.org/10.1016/S0968-0004(00)88978-1

Induction of proto-oncogene JUN/AP-1 by serum and TPA
journal, August 1988

Lamph, William W.; Wamsley, Penny; Sassone-Corsi, Paolo
Nature, Vol. 334, Issue 6183
https://doi.org/10.1038/334629a0

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
journal, March 1994

Dérijard, Benoit; Hibi, Masahiko; Wu, I-Huan
Cell, Vol. 76, Issue 6
https://doi.org/10.1016/0092-8674(94)90380-8

Structure and chromosomal localization of the functional intronless human JUN protooncogene.
journal, December 1988

Hattori, K.; Angel, P.; Le Beau, M. M.
Proceedings of the National Academy of Sciences, Vol. 85, Issue 23
https://doi.org/10.1073/pnas.85.23.9148

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
journal, November 2001

Bennett, B. L.; Sasaki, D. T.; Murray, B. W.
Proceedings of the National Academy of Sciences, Vol. 98, Issue 24
https://doi.org/10.1073/pnas.251194298

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
journal, July 1990

Boulton, T.; Yancopoulos, G.; Gregory, J.
Science, Vol. 249, Issue 4964
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Targeting JNK for therapeutic benefit: from junk to gold?
journal, July 2003

Manning, Anthony M.; Davis, Roger J.
Nature Reviews Drug Discovery, Vol. 2, Issue 7
https://doi.org/10.1038/nrd1132

DNA-binding activity of jun is increased through its interaction with Fos
journal, April 1990

Allegretto, Elizabeth A.; Smeal, Tod; Angel, Peter
Journal of Cellular Biochemistry, Vol. 42, Issue 4
https://doi.org/10.1002/jcb.240420403

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
journal, February 1990

Anderson, Neil G.; Maller, James L.; Tonks, Nicholas K.
Nature, Vol. 343, Issue 6259
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Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
journal, June 1992

Adler, V.; Franklin, C. C.; Kraft, A. S.
Proceedings of the National Academy of Sciences, Vol. 89, Issue 12
https://doi.org/10.1073/pnas.89.12.5341

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
journal, August 1988

Ryseck, R. -P.; Hirai, S. I.; Yaniv, M.
Nature, Vol. 334, Issue 6182
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Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin.
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Suggs, S. V.; Wallace, R. B.; Hirose, T.
Proceedings of the National Academy of Sciences, Vol. 78, Issue 11
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Phosphorylation of c-jun mediated by MAP kinases
journal, October 1991

Pulverer, Bernd J.; Kyriakis, John M.; Avruch, Joseph
Nature, Vol. 353, Issue 6345
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Similar Records

Title: Oncoprotein protein kinase

Abstract

Citation Formats

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis journal, July 2001

Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase journal, March 1988

Induction of protooncogene c-jun by serum growth factors. journal, November 1988

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. journal, October 1994

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. journal, November 1993

A central role for JNK in obesity and insulin resistance journal, November 2002

Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 journal, December 1987

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF journal, May 1991

Parallel signal processing among mammalian MAPKs journal, March 1995

Induction of proto-oncogene JUN/AP-1 by serum and TPA journal, August 1988

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain journal, March 1994

Structure and chromosomal localization of the functional intronless human JUN protooncogene. journal, December 1988

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase journal, November 2001

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control journal, July 1990

Targeting JNK for therapeutic benefit: from junk to gold? journal, July 2003

DNA-binding activity of jun is increased through its interaction with Fos journal, April 1990

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase journal, February 1990

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain. journal, June 1992

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts journal, August 1988

Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin. journal, November 1981

Phosphorylation of c-jun mediated by MAP kinases journal, October 1991

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
journal, July 2001

Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase
journal, March 1988

Induction of protooncogene c-jun by serum growth factors.
journal, November 1988

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.
journal, October 1994

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
journal, November 1993

A central role for JNK in obesity and insulin resistance
journal, November 2002

Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
journal, December 1987

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
journal, May 1991

Parallel signal processing among mammalian MAPKs
journal, March 1995

Induction of proto-oncogene JUN/AP-1 by serum and TPA
journal, August 1988

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
journal, March 1994

Structure and chromosomal localization of the functional intronless human JUN protooncogene.
journal, December 1988

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
journal, November 2001

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
journal, July 1990

Targeting JNK for therapeutic benefit: from junk to gold?
journal, July 2003

DNA-binding activity of jun is increased through its interaction with Fos
journal, April 1990

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
journal, February 1990

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
journal, June 1992

Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
journal, August 1988

Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin.
journal, November 1981

Phosphorylation of c-jun mediated by MAP kinases
journal, October 1991