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Title: Oncoprotein protein kinase

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175214
Patent Number(s):
6846644
Application Number:
09/861,098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
86ER60429
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Davis, Roger, Derijard, Benoit, Karin, Michael, Hibi, Masahiko, and Lin, Anning. Oncoprotein protein kinase. United States: N. p., 2005. Web.
Davis, Roger, Derijard, Benoit, Karin, Michael, Hibi, Masahiko, & Lin, Anning. Oncoprotein protein kinase. United States.
Davis, Roger, Derijard, Benoit, Karin, Michael, Hibi, Masahiko, and Lin, Anning. Tue . "Oncoprotein protein kinase". United States. https://www.osti.gov/servlets/purl/1175214.
@article{osti_1175214,
title = {Oncoprotein protein kinase},
author = {Davis, Roger and Derijard, Benoit and Karin, Michael and Hibi, Masahiko and Lin, Anning},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {1}
}

Works referenced in this record:

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
journal, July 2001


Induction of protooncogene c-jun by serum growth factors.
journal, November 1988


A central role for JNK in obesity and insulin resistance
journal, November 2002


Parallel signal processing among mammalian MAPKs
journal, March 1995


Induction of proto-oncogene JUN/AP-1 by serum and TPA
journal, August 1988


Structure and chromosomal localization of the functional intronless human JUN protooncogene.
journal, December 1988


SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
journal, November 2001


An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
journal, July 1990


Targeting JNK for therapeutic benefit: from junk to gold?
journal, July 2003


DNA-binding activity of jun is increased through its interaction with Fos
journal, April 1990


Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
journal, February 1990


Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
journal, June 1992


Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
journal, August 1988


Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin.
journal, November 1981


Phosphorylation of c-jun mediated by MAP kinases
journal, October 1991