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Title: Oncoprotein protein kinase

Abstract

An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175214
Patent Number(s):
6846644
Application Number:
09/861,098
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
86ER60429
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Davis, Roger, Derijard, Benoit, Karin, Michael, Hibi, Masahiko, and Lin, Anning. Oncoprotein protein kinase. United States: N. p., 2005. Web.
Davis, Roger, Derijard, Benoit, Karin, Michael, Hibi, Masahiko, & Lin, Anning. Oncoprotein protein kinase. United States.
Davis, Roger, Derijard, Benoit, Karin, Michael, Hibi, Masahiko, and Lin, Anning. Tue . "Oncoprotein protein kinase". United States. https://www.osti.gov/servlets/purl/1175214.
@article{osti_1175214,
title = {Oncoprotein protein kinase},
author = {Davis, Roger and Derijard, Benoit and Karin, Michael and Hibi, Masahiko and Lin, Anning},
abstractNote = {An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {1}
}

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Works referenced in this record:

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
journal, July 2001


Induction of protooncogene c-jun by serum growth factors.
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A central role for JNK in obesity and insulin resistance
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Parallel signal processing among mammalian MAPKs
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Structure and chromosomal localization of the functional intronless human JUN protooncogene.
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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
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An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
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Targeting JNK for therapeutic benefit: from junk to gold?
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DNA-binding activity of jun is increased through its interaction with Fos
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Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
journal, February 1990


Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
journal, June 1992


Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts
journal, August 1988


Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin.
journal, November 1981


Phosphorylation of c-jun mediated by MAP kinases
journal, October 1991