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Title: 4-haloethenylphenyl tropane:serotonin transporter imaging agents

Abstract

A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.

Inventors:
;
Issue Date:
Research Org.:
Emory Univ., Atlanta, GA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175203
Patent Number(s):
6843979
Application Number:
09/974,729
Assignee:
Emory University (Atlanta, GA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
FG02-97ER62367
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Goodman, Mark M., and Martarello, Laurent. 4-haloethenylphenyl tropane:serotonin transporter imaging agents. United States: N. p., 2005. Web.
Goodman, Mark M., & Martarello, Laurent. 4-haloethenylphenyl tropane:serotonin transporter imaging agents. United States.
Goodman, Mark M., and Martarello, Laurent. Tue . "4-haloethenylphenyl tropane:serotonin transporter imaging agents". United States. https://www.osti.gov/servlets/purl/1175203.
@article{osti_1175203,
title = {4-haloethenylphenyl tropane:serotonin transporter imaging agents},
author = {Goodman, Mark M. and Martarello, Laurent},
abstractNote = {A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {1}
}

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Works referenced in this record:

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