4-haloethenylphenyl tropane:serotonin transporter imaging agents
Abstract
A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.
- Inventors:
- Issue Date:
- Research Org.:
- Emory Univ., Atlanta, GA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175203
- Patent Number(s):
- 6843979
- Application Number:
- 09/974,729
- Assignee:
- Emory University (Atlanta, GA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- FG02-97ER62367
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Goodman, Mark M., and Martarello, Laurent. 4-haloethenylphenyl tropane:serotonin transporter imaging agents. United States: N. p., 2005.
Web.
Goodman, Mark M., & Martarello, Laurent. 4-haloethenylphenyl tropane:serotonin transporter imaging agents. United States.
Goodman, Mark M., and Martarello, Laurent. Tue .
"4-haloethenylphenyl tropane:serotonin transporter imaging agents". United States. https://www.osti.gov/servlets/purl/1175203.
@article{osti_1175203,
title = {4-haloethenylphenyl tropane:serotonin transporter imaging agents},
author = {Goodman, Mark M. and Martarello, Laurent},
abstractNote = {A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {1}
}
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