Piperazine-based nucleic acid analogs

Schmidt, Jurgen; Silks, Louis A.; Michalczyk, Ryszard

Title: Piperazine-based nucleic acid analogs

Full Record
Other Related Research

Abstract

A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.

Inventors:: Schmidt, Jurgen; Silks, Louis A.; Michalczyk, Ryszard

Issue Date:: 2005-01-11

Research Org.:: Univ. of California, Oakland, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175200

Patent Number(s):: 6841675

Application Number:: 10/171,073

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

Show more

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D403/06 - linked by a carbon chain containing only aliphatic carbon atoms

Show less

DOE Contract Number:: W-7405-ENG-36

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Schmidt, Jurgen, Silks, Louis A., and Michalczyk, Ryszard. Piperazine-based nucleic acid analogs.  United States: N. p., 2005. 
        Web.

Copy to clipboard


                    Schmidt, Jurgen, Silks, Louis A., & Michalczyk, Ryszard. Piperazine-based nucleic acid analogs.  United States.

Copy to clipboard


                    Schmidt, Jurgen, Silks, Louis A., and Michalczyk, Ryszard. Tue .  
        "Piperazine-based nucleic acid analogs".  United States.  https://www.osti.gov/servlets/purl/1175200.

Copy to clipboard


                    
@article{osti_1175200,

  title        = {Piperazine-based nucleic acid analogs},

  author       = {Schmidt, Jurgen and Silks, Louis A. and Michalczyk, Ryszard},

  abstractNote = {A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2005},

  month        = {1}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE Patents and OSTI.GOV collections:

Chip-based device for parallel sorting, amplification, detection, and identification of nucleic acid subsequences

Patent Beer, Neil Reginald; Colston, Jr, Billy W.

An apparatus for chip-based sorting, amplification, detection, and identification of a sample having a planar substrate. The planar substrate is divided into cells. The cells are arranged on the planar substrate in rows and columns. Electrodes are located in the cells. A micro-reactor maker produces micro-reactors containing the sample. The micro-reactor maker is positioned to deliver the micro-reactors to the planar substrate. A microprocessor is connected to the electrodes for manipulating the micro-reactors on the planar substrate. A detector is positioned to interrogate the sample contained in the micro-reactors.
Full Text Available
Identifying a base in a nucleic acid

Patent Fodor, Stephen P. A.; Lipshutz, Robert J.; Huang, Xiaohua

Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.
Full Text Available
Frequency-based modulation of diverse species in a nucleic acid library

Patent Kalhor, Reza; Juarez, Javier Fernandez; Lee, Henry Hung-yi; ...

A method of processing a collection of nucleic acid sequences is provided including connecting an adaptor to one or more or each nucleic acid sequence in the collection to create a processed nucleic acid template library, wherein the adaptor includes a first DNA sequence encoding a PAM sequence and at least a tracr mate.
Full Text Available
Probe kit for identifying a base in a nucleic acid

Patent Fodor, Stephen P. A. [Palo Alto, CA]; Lipshutz, Robert J [Palo Alto, CA]; Huang, Xiaohua [Mt. View, CA]

Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.
Full Text Available
Method of Identifying a Base in a Nucleic Acid

Patent Fodor, Stephen P. A. [Palo Alto, CA]; Lipshutz, Robert J [Palo Alto, CA]; Huang, Xiaohua [Mt. View, CA]

Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.
Full Text Available

Similar Records