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Title: Piperazine-based nucleic acid analogs

Abstract

A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.

Inventors:
; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175200
Patent Number(s):
6841675
Application Number:
10/171,073
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
W-7405-ENG-36
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Schmidt, Jurgen, Silks, Louis A., and Michalczyk, Ryszard. Piperazine-based nucleic acid analogs. United States: N. p., 2005. Web.
Schmidt, Jurgen, Silks, Louis A., & Michalczyk, Ryszard. Piperazine-based nucleic acid analogs. United States.
Schmidt, Jurgen, Silks, Louis A., and Michalczyk, Ryszard. Tue . "Piperazine-based nucleic acid analogs". United States. https://www.osti.gov/servlets/purl/1175200.
@article{osti_1175200,
title = {Piperazine-based nucleic acid analogs},
author = {Schmidt, Jurgen and Silks, Louis A. and Michalczyk, Ryszard},
abstractNote = {A novel nucleoside analog is disclosed which comprises a piperazine ring in the place of the ring ribose or deoxyribose sugar. Monomers utilizing a broad variety of nucleobases are disclosed, as well as oligomers comprising the monomers disclosed herein linked by a variety of linkages, including amide, phosphonamide, and sulfonamide linkages. A method of synthesizing the nucleoside analogs is also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2005},
month = {1}
}

Patent:

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