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Title: Impedance measurements for detecting pathogens attached to antibodies

Abstract

The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode attach to the immobilized antibodies, which produces a change in impedance between two adjacent electrodes, which impedance change is measured and used to detect the presence of a pathogen. To amplify the signal, beads coated with antibodies are introduced and the beads would stick to the pathogen causing a greater change in impedance between the two adjacent electrodes.

Inventors:
; ;
Issue Date:
Research Org.:
The Regents of the Univ. of California, Oakland, CA (United States); Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175183
Patent Number(s):
6835552
Application Number:
09/737,542
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Miles, Robin R., Venkateswaran, Kodumudi S., and Fuller, Christopher K.. Impedance measurements for detecting pathogens attached to antibodies. United States: N. p., 2004. Web.
Miles, Robin R., Venkateswaran, Kodumudi S., & Fuller, Christopher K.. Impedance measurements for detecting pathogens attached to antibodies. United States.
Miles, Robin R., Venkateswaran, Kodumudi S., and Fuller, Christopher K.. Tue . "Impedance measurements for detecting pathogens attached to antibodies". United States. https://www.osti.gov/servlets/purl/1175183.
@article{osti_1175183,
title = {Impedance measurements for detecting pathogens attached to antibodies},
author = {Miles, Robin R. and Venkateswaran, Kodumudi S. and Fuller, Christopher K.},
abstractNote = {The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated electrode. Pathogens in a sample fluid streaming past the electrode attach to the immobilized antibodies, which produces a change in impedance between two adjacent electrodes, which impedance change is measured and used to detect the presence of a pathogen. To amplify the signal, beads coated with antibodies are introduced and the beads would stick to the pathogen causing a greater change in impedance between the two adjacent electrodes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {12}
}

Patent:

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