Treatment of addiction and addiction-related behavior

Dewey, Stephen L.; Brodie, Jonathan D.; Ashby, Charles R.

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Title: Treatment of addiction and addiction-related behavior

Abstract

The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof.

Inventors:: Dewey, Stephen L.; Brodie, Jonathan D.; Ashby, Jr., Charles R.

Issue Date:: Tue Dec 07 00:00:00 EST 2004

Research Org.:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175166

Patent Number(s):: 6828349

Application Number:: 09/189,166

Assignee:: Brookhaven Science Associates (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/00 - Medicinal preparations containing organic active ingredients
A61K31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
A61K31/16 - Amides, e.g. hydroxamic acids
A61K31/165 - having aromatic rings, e.g. colchicine, atenolol, progabide
A61K31/19 - Carboxylic acids, e.g. valproic acid
A61K31/195 - having an amino group
A61K31/197 - the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K31/221 - with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K31/35 - having six-membered rings with one oxygen as the only ring hetero atom
A61K31/4535 - containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen

Show less

DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior.  United States: N. p., 2004. 
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                    Dewey, Stephen L., Brodie, Jonathan D., & Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior.  United States.

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                    Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R. Tue .  
        "Treatment of addiction and addiction-related behavior".  United States.  https://www.osti.gov/servlets/purl/1175166.

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@article{osti_1175166,

  title        = {Treatment of addiction and addiction-related behavior},

  author       = {Dewey, Stephen L. and Brodie, Jonathan D. and Ashby, Jr., Charles R.},

  abstractNote = {The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Dec 07 00:00:00 EST 2004},

  month        = {Tue Dec 07 00:00:00 EST 2004}

}

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Similar Records

Title: Treatment of addiction and addiction-related behavior

Abstract

Citation Formats

Facile selective detritylation of 5?-primary alcohols of pyrimidine nucleosides using tetra-n-butylammonium peroxydisulfate journal, January 1997

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure journal, June 1997

Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels journal, April 1993

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects. journal, December 1993

Detritylation of mono- and di-saccharide derivatives using ferric chloride hydrate journal, October 1997

Pharmacologic characterization of nicotine-induced conditioned place preference journal, February 1985

The use of zinc bromide for removal of dimethoxytrityl ethers from deoxynucleosides journal, January 1980

Vigabatrin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Epilepsy and Disorders of Motor Control journal, January 1991

Self-administration in rats allowed unlimited access to nicotine journal, October 1997

Use of the naphthalene radical ion in deblocking O-methoxytrityl nucleotide derivatives journal, January 1975

Selective Electrochemical Removal of Protecting Groups in Nucleotide Synthesis journal, February 1979

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens journal, September 1989

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine-Treated Rats journal, April 1997

Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area journal, January 1994

?-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE journal, November 1977

Stepwise Regeneration and Recovery of Deoxyribonucleoside Phosphoramidite Monomers During Solid-Phase Oligonucleotide Synthesis journal, April 1994

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. journal, July 1988

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis journal, June 1984

Selective deprotection by reductive cleavage with radical anions journal, November 1975

Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase journal, February 1997

Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels journal, January 1996

Perkin communications. 4,4′-Dimethoxytrityl and 4-monomethoxytrityl tetrafluoroborate: convenient reagents for the protection of primary alcohols including sugars journal, January 1990

Cigarette smokers self-administer intravenous nicotine journal, November 1983

DNA with Altered Backbones in Antisense Applications book, January 1999

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography journal, October 1992

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds journal, October 1997

Pharmacological treatment of tobacco dependence journal, May 1988

Gamma-Vinyl GABA Decreases Voluntary Alcohol Consumption in Alcohol-Preferring AA Rats journal, September 1993

The triphenylmethyl (trityl) group and its uses in nucleotide chemistry journal, January 1980

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats journal, December 1986

Selective hydrogenations promoted by copper catalysts. 1. Chemoselectivity, regioselectivity, and stereoselectivity in the hydrogenation of 3-substituted steroids journal, June 1991

Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats journal, October 1996

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward journal, May 1995

Carbohydrates: Synthetic Methods and Applications in Antisense Therapeutics book, December 1994

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders journal, March 1995

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release journal, December 1994

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice journal, June 1998

Facile methods to recycle nucleosides during solid phase synthesis of oligonucleotides journal, May 1994

Apparent absence of nicotine-induced conditioned place preference in rats journal, May 1987

Control of behavior by intravenous nicotine injections in human subjects journal, December 1983

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs book, January 1987

Imaging endogenous dopamine competition with [11C]raclopride in the human brain journal, April 1994

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs journal, July 1996

Treatment of Cocaine Abuse: Pharmacotherapy book, September 2007

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. journal, July 1988

Chemically Modified Oligonucleotides as Probes and Inhibitors journal, June 1991

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - 11 C-Methyl]-(−)-Cocaine PET Studies in Human Subjects journal, September 1990

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen journal, December 1990

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation journal, October 1997

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats journal, October 1996

Facile selective detritylation of 5?-primary alcohols of pyrimidine nucleosides using tetra-n-butylammonium peroxydisulfate
journal, January 1997

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure
journal, June 1997

Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels
journal, April 1993

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.
journal, December 1993

Detritylation of mono- and di-saccharide derivatives using ferric chloride hydrate
journal, October 1997

Pharmacologic characterization of nicotine-induced conditioned place preference
journal, February 1985

The use of zinc bromide for removal of dimethoxytrityl ethers from deoxynucleosides
journal, January 1980

Vigabatrin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Epilepsy and Disorders of Motor Control
journal, January 1991

Self-administration in rats allowed unlimited access to nicotine
journal, October 1997

Use of the naphthalene radical ion in deblocking O-methoxytrityl nucleotide derivatives
journal, January 1975

Selective Electrochemical Removal of Protecting Groups in Nucleotide Synthesis
journal, February 1979

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens
journal, September 1989

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine-Treated Rats
journal, April 1997

Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
journal, January 1994

?-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE
journal, November 1977

Stepwise Regeneration and Recovery of Deoxyribonucleoside Phosphoramidite Monomers During Solid-Phase Oligonucleotide Synthesis
journal, April 1994

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.
journal, July 1988

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
journal, June 1984

Selective deprotection by reductive cleavage with radical anions
journal, November 1975

Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase
journal, February 1997

Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels
journal, January 1996

Perkin communications. 4,4′-Dimethoxytrityl and 4-monomethoxytrityl tetrafluoroborate: convenient reagents for the protection of primary alcohols including sugars
journal, January 1990

Cigarette smokers self-administer intravenous nicotine
journal, November 1983

DNA with Altered Backbones in Antisense Applications
book, January 1999

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography
journal, October 1992

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds
journal, October 1997

Pharmacological treatment of tobacco dependence
journal, May 1988

Gamma-Vinyl GABA Decreases Voluntary Alcohol Consumption in Alcohol-Preferring AA Rats
journal, September 1993

The triphenylmethyl (trityl) group and its uses in nucleotide chemistry
journal, January 1980

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
journal, December 1986

Selective hydrogenations promoted by copper catalysts. 1. Chemoselectivity, regioselectivity, and stereoselectivity in the hydrogenation of 3-substituted steroids
journal, June 1991

Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats
journal, October 1996

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward
journal, May 1995

Carbohydrates: Synthetic Methods and Applications in Antisense Therapeutics
book, December 1994

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders
journal, March 1995

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release
journal, December 1994

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
journal, June 1998

Facile methods to recycle nucleosides during solid phase synthesis of oligonucleotides
journal, May 1994

Apparent absence of nicotine-induced conditioned place preference in rats
journal, May 1987

Control of behavior by intravenous nicotine injections in human subjects
journal, December 1983

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs
book, January 1987

Imaging endogenous dopamine competition with [11C]raclopride in the human brain
journal, April 1994

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
journal, July 1996

Treatment of Cocaine Abuse: Pharmacotherapy
book, September 2007

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
journal, July 1988

Chemically Modified Oligonucleotides as Probes and Inhibitors
journal, June 1991

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - ¹¹ C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
journal, September 1990

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen
journal, December 1990

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation
journal, October 1997

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats
journal, October 1996