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Title: Treatment of addiction and addiction-related behavior

Abstract

The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof.

Inventors:
; ;
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175166
Patent Number(s):
6828349
Application Number:
09/189,166
Assignee:
Brookhaven Science Associates (Upton, NY)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R.. Treatment of addiction and addiction-related behavior. United States: N. p., 2004. Web.
Dewey, Stephen L., Brodie, Jonathan D., & Ashby, Jr., Charles R.. Treatment of addiction and addiction-related behavior. United States.
Dewey, Stephen L., Brodie, Jonathan D., and Ashby, Jr., Charles R.. Tue . "Treatment of addiction and addiction-related behavior". United States. https://www.osti.gov/servlets/purl/1175166.
@article{osti_1175166,
title = {Treatment of addiction and addiction-related behavior},
author = {Dewey, Stephen L. and Brodie, Jonathan D. and Ashby, Jr., Charles R.},
abstractNote = {The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof. The present invention also provides a method of treatment of cocaine, morphine, heroin, nicotine, amphetamine, methamphetamine, or ethanol addiction by treating a mammal with an effective amount of gamma vinylGABA or a pharmaceutically acceptable salt thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {12}
}

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Works referenced in this record:

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure
journal, June 1997


Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels
journal, April 1993


Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.
journal, December 1993


Detritylation of mono- and di-saccharide derivatives using ferric chloride hydrate
journal, October 1997


Pharmacologic characterization of nicotine-induced conditioned place preference
journal, February 1985


The use of zinc bromide for removal of dimethoxytrityl ethers from deoxynucleosides
journal, January 1980


Self-administration in rats allowed unlimited access to nicotine
journal, October 1997


Use of the naphthalene radical ion in deblocking O-methoxytrityl nucleotide derivatives
journal, January 1975


Selective Electrochemical Removal of Protecting Groups in Nucleotide Synthesis
journal, February 1979


Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens
journal, September 1989


Stepwise Regeneration and Recovery of Deoxyribonucleoside Phosphoramidite Monomers During Solid-Phase Oligonucleotide Synthesis
journal, April 1994


On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.
journal, July 1988


Selective deprotection by reductive cleavage with radical anions
journal, November 1975


Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase
journal, February 1997


Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels
journal, January 1996


Cigarette smokers self-administer intravenous nicotine
journal, November 1983


Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds
journal, October 1997


Pharmacological treatment of tobacco dependence
journal, May 1988


Gamma-Vinyl GABA Decreases Voluntary Alcohol Consumption in Alcohol-Preferring AA Rats
journal, September 1993


The triphenylmethyl (trityl) group and its uses in nucleotide chemistry
journal, January 1980


Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
journal, December 1986


Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats
journal, October 1996


Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward
journal, May 1995


Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders
journal, March 1995


Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release
journal, December 1994


Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
journal, June 1998


Apparent absence of nicotine-induced conditioned place preference in rats
journal, May 1987


Control of behavior by intravenous nicotine injections in human subjects
journal, December 1983


Imaging endogenous dopamine competition with [11C]raclopride in the human brain
journal, April 1994


Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
journal, July 1996


Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
journal, July 1988


Chemically Modified Oligonucleotides as Probes and Inhibitors
journal, June 1991


Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - 11 C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
journal, September 1990


A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation
journal, October 1997


Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats
journal, October 1996