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Title: Phosphoprotein binding agents and methods of their use

Abstract

The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified such that they contain phosphate groups at either some or all of their serine, threonine, tyrosine, histidine, and/or lysine amino acid residues. In many cases the extent to which a protein is phosphorylated determines it bioactivity, i.e., its ability to effect cell functions such as differentiation, division, and metabolism. Hence, a powerful tool for diagnosing various diseases and for furthering the understanding of protein--protein interactions is provided.

Inventors:
; ; ;
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175129
Patent Number(s):
6818454
Application Number:
09/788,286
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Goshe, Michael B., Conrads, Thomas P., Veenstra, Timothy D., and Panisko, Ellen A.. Phosphoprotein binding agents and methods of their use. United States: N. p., 2004. Web.
Goshe, Michael B., Conrads, Thomas P., Veenstra, Timothy D., & Panisko, Ellen A.. Phosphoprotein binding agents and methods of their use. United States.
Goshe, Michael B., Conrads, Thomas P., Veenstra, Timothy D., and Panisko, Ellen A.. Tue . "Phosphoprotein binding agents and methods of their use". United States. https://www.osti.gov/servlets/purl/1175129.
@article{osti_1175129,
title = {Phosphoprotein binding agents and methods of their use},
author = {Goshe, Michael B. and Conrads, Thomas P. and Veenstra, Timothy D. and Panisko, Ellen A.},
abstractNote = {The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified such that they contain phosphate groups at either some or all of their serine, threonine, tyrosine, histidine, and/or lysine amino acid residues. In many cases the extent to which a protein is phosphorylated determines it bioactivity, i.e., its ability to effect cell functions such as differentiation, division, and metabolism. Hence, a powerful tool for diagnosing various diseases and for furthering the understanding of protein--protein interactions is provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {11}
}

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Works referenced in this record:

Expression and phosphorylation status of retinoblastoma protein in adult T-cell leukemia/lymphoma
journal, April 2000


Sequence analysis of phosphoserine-containing peptides: Modification for picomolar sensitivity
journal, August 1986


Selective analysis of phosphopeptides within a protein mixture by chemical modification, reversible biotinylation and mass spectrometry
journal, January 2001


Quantitative analysis of complex protein mixtures using isotope-coded affinity tags
journal, October 1999