Phosphoprotein binding agents and methods of their use
Abstract
The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified such that they contain phosphate groups at either some or all of their serine, threonine, tyrosine, histidine, and/or lysine amino acid residues. In many cases the extent to which a protein is phosphorylated determines it bioactivity, i.e., its ability to effect cell functions such as differentiation, division, and metabolism. Hence, a powerful tool for diagnosing various diseases and for furthering the understanding of protein--protein interactions is provided.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1175129
- Patent Number(s):
- 6818454
- Application Number:
- 09/788,286
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- DOE Contract Number:
- AC06-76RL01830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Goshe, Michael B., Conrads, Thomas P., Veenstra, Timothy D., and Panisko, Ellen A. Phosphoprotein binding agents and methods of their use. United States: N. p., 2004.
Web.
Goshe, Michael B., Conrads, Thomas P., Veenstra, Timothy D., & Panisko, Ellen A. Phosphoprotein binding agents and methods of their use. United States.
Goshe, Michael B., Conrads, Thomas P., Veenstra, Timothy D., and Panisko, Ellen A. Tue .
"Phosphoprotein binding agents and methods of their use". United States. https://www.osti.gov/servlets/purl/1175129.
@article{osti_1175129,
title = {Phosphoprotein binding agents and methods of their use},
author = {Goshe, Michael B. and Conrads, Thomas P. and Veenstra, Timothy D. and Panisko, Ellen A.},
abstractNote = {The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified such that they contain phosphate groups at either some or all of their serine, threonine, tyrosine, histidine, and/or lysine amino acid residues. In many cases the extent to which a protein is phosphorylated determines it bioactivity, i.e., its ability to effect cell functions such as differentiation, division, and metabolism. Hence, a powerful tool for diagnosing various diseases and for furthering the understanding of protein--protein interactions is provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 16 00:00:00 EST 2004},
month = {Tue Nov 16 00:00:00 EST 2004}
}
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