Uses of Ku70

Li, Gloria C.; Cordon-Cardo, Carlos; Ouyang, Honghai

Title: Uses of Ku70

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Abstract

This invention provides a method of diagnosing a predisposition to cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and; (b) determining whether one or more of the subject's Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subject's expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and (b) determining whether one or more of the subject's Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subject's expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: determining the subcellular localization of Ku70 in the subject, wherein an abnormal subcellular localization of Ku70 indicates a predisposition to cancer.

Inventors:: Li, Gloria C.; Cordon-Cardo, Carlos; Ouyang, Honghai

Issue Date:: 2004-10-26

Research Org.:: Sloan-Kettering Institute For Cancer Research, New York, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175095

Patent Number(s):: 6808887

Application Number:: 10/161,025

Assignee:: Sloan-Kettering Institute For Cancer Research

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

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C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q2600/106 - Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/143333 - Saccharide [e.g., DNA, etc.]

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/6886 - for cancer
C12Q2600/112 - Disease subtyping, staging or classification

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Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Li, Gloria C., Cordon-Cardo, Carlos, and Ouyang, Honghai. Uses of Ku70.  United States: N. p., 2004. 
        Web.

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                    Li, Gloria C., Cordon-Cardo, Carlos, & Ouyang, Honghai. Uses of Ku70.  United States.

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                    Li, Gloria C., Cordon-Cardo, Carlos, and Ouyang, Honghai. Tue .  
        "Uses of Ku70".  United States.  https://www.osti.gov/servlets/purl/1175095.

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@article{osti_1175095,

  title        = {Uses of Ku70},

  author       = {Li, Gloria C. and Cordon-Cardo, Carlos and Ouyang, Honghai},

  abstractNote = {This invention provides a method of diagnosing a predisposition to cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and; (b) determining whether one or more of the subject's Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subject's expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and (b) determining whether one or more of the subject's Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subject's expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: determining the subcellular localization of Ku70 in the subject, wherein an abnormal subcellular localization of Ku70 indicates a predisposition to cancer.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2004},

  month        = {10}

}

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