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Title: Purine inhibitors of protein kinases, G proteins and polymerases

Abstract

The present invention relates to 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.

Inventors:
; ; ;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States); Centre National de la Recherche (France)
Sponsoring Org.:
USDOE
OSTI Identifier:
1175071
Patent Number(s):
6803371
Application Number:
10/352,752
Assignee:
The Regents of the University of California (Oakland, CA); Centre National de la Recherche (FR)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Gray, Nathanael S., Schultz, Peter, Kim, Sung-Hou, and Meijer, Laurent. Purine inhibitors of protein kinases, G proteins and polymerases. United States: N. p., 2004. Web.
Gray, Nathanael S., Schultz, Peter, Kim, Sung-Hou, & Meijer, Laurent. Purine inhibitors of protein kinases, G proteins and polymerases. United States.
Gray, Nathanael S., Schultz, Peter, Kim, Sung-Hou, and Meijer, Laurent. Tue . "Purine inhibitors of protein kinases, G proteins and polymerases". United States. https://www.osti.gov/servlets/purl/1175071.
@article{osti_1175071,
title = {Purine inhibitors of protein kinases, G proteins and polymerases},
author = {Gray, Nathanael S. and Schultz, Peter and Kim, Sung-Hou and Meijer, Laurent},
abstractNote = {The present invention relates to 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {10}
}

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Works referenced in this record:

Combinatorial synthesis of 2,9-substituted purines
journal, February 1997


Inhibition of Cyclin-Dependent Kinases by Purine Analogues
journal, September 1994


Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors:  Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds
journal, February 1997


A Structure-Based Library Approach to Kinase Inhibitors
journal, January 1996


Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors
journal, June 1999


Synthesis and activity of 2,6,9-trisubstituted purines
journal, November 1997


Inhibition of Cyclin-Dependent Kinases by Purine Analogues. Crystal Structure of Human cdk2 Complexed with Roscovitine
journal, January 1997