Purine inhibitors of protein kinases, G proteins and polymerases

Gray, Nathanael S.; Schultz, Peter; Kim, Sung-Hou; Meijer, Laurent

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Title: Purine inhibitors of protein kinases, G proteins and polymerases

Abstract

The present invention relates to 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.

Inventors:: Gray, Nathanael S.; Schultz, Peter; Kim, Sung-Hou; Meijer, Laurent

Issue Date:: 2004-10-12

Research Org.:: Univ. of California, Oakland, CA (United States); Centre National de la Recherche (France)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1175071

Patent Number(s):: 6803371

Application Number:: 10/352,752

Assignee:: The Regents of the University of California (Oakland, CA); Centre National de la Recherche (FR)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/52 - Purines, e.g. adenine

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P25/28 - for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P35/00 - Antineoplastic agents

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D473/16 - two nitrogen atoms

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Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Gray, Nathanael S., Schultz, Peter, Kim, Sung-Hou, and Meijer, Laurent. Purine inhibitors of protein kinases, G proteins and polymerases.  United States: N. p., 2004. 
        Web.

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                    Gray, Nathanael S., Schultz, Peter, Kim, Sung-Hou, & Meijer, Laurent. Purine inhibitors of protein kinases, G proteins and polymerases.  United States.

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                    Gray, Nathanael S., Schultz, Peter, Kim, Sung-Hou, and Meijer, Laurent. Tue .  
        "Purine inhibitors of protein kinases, G proteins and polymerases".  United States.  https://www.osti.gov/servlets/purl/1175071.

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@article{osti_1175071,

  title        = {Purine inhibitors of protein kinases, G proteins and polymerases},

  author       = {Gray, Nathanael S. and Schultz, Peter and Kim, Sung-Hou and Meijer, Laurent},

  abstractNote = {The present invention relates to 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines that inhibit, inter alia, protein kinases, G-proteins and polymerases. In addition, the present invention relates to methods of using such 2-N-substituted 6-(4-methoxybenzylamino)-9-isopropylpurines to inhibit protein kinases, G-proteins, polymerases and other cellular processes and to treat cellular proliferative diseases.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2004},

  month        = {10}

}

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Works referenced in this record:

Combinatorial synthesis of 2,9-substituted purines
journal, February 1997

Gray, Nathanael S.; Kwon, Soojin; Schultz, Peter G.
Tetrahedron Letters, Vol. 38, Issue 7
https://doi.org/10.1016/S0040-4039(97)00014-2

Inhibition of Cyclin-Dependent Kinases by Purine Analogues
journal, September 1994

Vesely, Jaroslav; Havlicek, Libor; Strnad, Miroslav
European Journal of Biochemistry, Vol. 224, Issue 2
https://doi.org/10.1111/j.1432-1033.1994.00771.x

Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds
journal, February 1997

Havlíček, Libor; Hanuš, Jan; Veselý, Jaroslav
Journal of Medicinal Chemistry, Vol. 40, Issue 4
https://doi.org/10.1021/jm960666x

A Structure-Based Library Approach to Kinase Inhibitors
journal, January 1996

Norman, Thea C.; Gray, Nathanael S.; Koh, John T.
Journal of the American Chemical Society, Vol. 118, Issue 31
https://doi.org/10.1021/ja9614934

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors
journal, June 1999

Chang, Young-Tae; Gray, Nathanael S.; Rosania, Gustavo R.
Chemistry & Biology, Vol. 6, Issue 6
https://doi.org/10.1016/S1074-5521(99)80048-9

Synthesis and activity of 2,6,9-trisubstituted purines
journal, November 1997

Schow, Steven R.; Mackman, Richard L.; Blum, Cheri L.
Bioorganic & Medicinal Chemistry Letters, Vol. 7, Issue 21
https://doi.org/10.1016/S0960-894X(97)10076-2

Inhibition of Cyclin-Dependent Kinases by Purine Analogues. Crystal Structure of Human cdk2 Complexed with Roscovitine
journal, January 1997

Azevedo, Walter Filgueira; Leclerc, Sophie; Meijer, Laurent
European Journal of Biochemistry, Vol. 243, Issue 1-2
https://doi.org/10.1111/j.1432-1033.1997.0518a.x

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Similar Records

Title: Purine inhibitors of protein kinases, G proteins and polymerases

Abstract

Citation Formats

Combinatorial synthesis of 2,9-substituted purines journal, February 1997

Inhibition of Cyclin-Dependent Kinases by Purine Analogues journal, September 1994

Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds journal, February 1997

A Structure-Based Library Approach to Kinase Inhibitors journal, January 1996

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors journal, June 1999

Synthesis and activity of 2,6,9-trisubstituted purines journal, November 1997

Inhibition of Cyclin-Dependent Kinases by Purine Analogues. Crystal Structure of Human cdk2 Complexed with Roscovitine journal, January 1997

Combinatorial synthesis of 2,9-substituted purines
journal, February 1997

Inhibition of Cyclin-Dependent Kinases by Purine Analogues
journal, September 1994

Cytokinin-Derived Cyclin-Dependent Kinase Inhibitors: Synthesis and cdc2 Inhibitory Activity of Olomoucine and Related Compounds
journal, February 1997

A Structure-Based Library Approach to Kinase Inhibitors
journal, January 1996

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors
journal, June 1999

Synthesis and activity of 2,6,9-trisubstituted purines
journal, November 1997

Inhibition of Cyclin-Dependent Kinases by Purine Analogues. Crystal Structure of Human cdk2 Complexed with Roscovitine
journal, January 1997