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Title: Metalloporphyrins and their uses as radiosensitizers for radiation therapy

Abstract

The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron--capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.

Inventors:
;
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174934
Patent Number(s):
6759403
Application Number:
10/117,010
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Miura, Michiko, and Slatkin, Daniel N. Metalloporphyrins and their uses as radiosensitizers for radiation therapy. United States: N. p., 2004. Web.
Miura, Michiko, & Slatkin, Daniel N. Metalloporphyrins and their uses as radiosensitizers for radiation therapy. United States.
Miura, Michiko, and Slatkin, Daniel N. Tue . "Metalloporphyrins and their uses as radiosensitizers for radiation therapy". United States. https://www.osti.gov/servlets/purl/1174934.
@article{osti_1174934,
title = {Metalloporphyrins and their uses as radiosensitizers for radiation therapy},
author = {Miura, Michiko and Slatkin, Daniel N.},
abstractNote = {The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron--capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {7}
}

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Works referenced in this record:

19F NMR Spectra and Structures of Halogenated Porphyrins
journal, July 1995


In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer
journal, November 1999


Evaluation of carborane-containing porphyrins as tumour targeting agents for boron neutron capture therapy.
journal, July 1998


A Straightforward Synthesis of 3,4-Difluoropyrrole
journal, August 1998