Detection of biological molecules using boronate-based chemical amplification and optical sensors

Van Antwerp, William Peter; Mastrototaro, John Joseph; Lane, Stephen M.; Satcher, Joe H.; Darrow, Christopher B.; Peyser, Thomas A.; Harder, Jennifer

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Title: Detection of biological molecules using boronate-based chemical amplification and optical sensors

Abstract

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

Inventors:: Van Antwerp, William Peter; Mastrototaro, John Joseph; Lane, Stephen M.; Satcher, Jr., Joe H.; Darrow, Christopher B.; Peyser, Thomas A.; Harder, Jennifer

Issue Date:: 2004-06-15

Research Org.:: MiniMed Inc., Sylmar, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1174901

Patent Number(s):: 6750311

Application Number:: 09/461,627

Assignee:: MiniMed Inc. (Sylmar, CA)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/66 - involving blood sugars, e.g. galactose

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T428/31551 - Of polyamidoester [polyurethane, polyisocyanate, polycarbamate, etc.]

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DOE Contract Number:: W-7405-ENG-48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M., Satcher, Jr., Joe H., Darrow, Christopher B., Peyser, Thomas A., and Harder, Jennifer. Detection of biological molecules using boronate-based chemical amplification and optical sensors.  United States: N. p., 2004. 
        Web.

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                    Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M., Satcher, Jr., Joe H., Darrow, Christopher B., Peyser, Thomas A., & Harder, Jennifer. Detection of biological molecules using boronate-based chemical amplification and optical sensors.  United States.

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                    Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M., Satcher, Jr., Joe H., Darrow, Christopher B., Peyser, Thomas A., and Harder, Jennifer. Tue .  
        "Detection of biological molecules using boronate-based chemical amplification and optical sensors".  United States.  https://www.osti.gov/servlets/purl/1174901.

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@article{osti_1174901,

  title        = {Detection of biological molecules using boronate-based chemical amplification and optical sensors},

  author       = {Van Antwerp, William Peter and Mastrototaro, John Joseph and Lane, Stephen M. and Satcher, Jr., Joe H. and Darrow, Christopher B. and Peyser, Thomas A. and Harder, Jennifer},

  abstractNote = {Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2004},

  month        = {6}

}

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Works referenced in this record:

Purification and partial characterization of a mitogenic lectin from vicia sativa
journal, March 1979

Falasca, A.; Franceschi, C.; Rossi, C. A.
Biochimica et Biophysica Acta (BBA) - Protein Structure, Vol. 577, Issue 1
https://doi.org/10.1016/0005-2795(79)90009-6

Arylboronic Acids. VI. Aminoboronic Anhydrides and a New Heterocycle Containing Boron ^1,2
journal, August 1960

Hawkins, Richard T.; Snyder, H. R.
Journal of the American Chemical Society, Vol. 82, Issue 15
https://doi.org/10.1021/ja01500a019

Aldehyde Syntheses. Study of the preparation of 9,10-anthracenedicarboxaldehyde
journal, December 1979

Lin, Yang-I; Lang, S. A.; Seifert, Christina M.
The Journal of Organic Chemistry, Vol. 44, Issue 25
https://doi.org/10.1021/jo00393a050

Molecular Fluorescence Sensor for Saccharides Based on Amino Coumarin
journal, February 1995

Sandanayake, K. R. A. Samankumara; Imazu, Sachiko; D. James, Tony
Chemistry Letters, Vol. 24, Issue 2
https://doi.org/10.1246/cl.1995.139

Fluorescent chemosensors of carbohydrates. A means of chemically communicating the binding of polyols in water based on chelation-enhanced quenching
journal, July 1992

Yoon, Juyoung; Czarnik, Anthony W.
Journal of the American Chemical Society, Vol. 114, Issue 14
https://doi.org/10.1021/ja00040a067

Determination of physiological levels of glucose in an aqueous matrix with digitally filtered Fourier transform near-infrared spectra
journal, July 1990

Arnold, Mark A.; Small, Gary W.
Analytical Chemistry, Vol. 62, Issue 14
https://doi.org/10.1021/ac00213a021

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
journal, September 1993

The Diabetes Control and Complications Trial Research Group,
New England Journal of Medicine, Vol. 329, Issue 14, p. 977-986
https://doi.org/10.1056/NEJM199309303291401

Quantitative determination of blood glucose using enzyme induced chemiluminescence of luminol
journal, March 1975

Bostick, Debra T.; Hercules, David M.
Analytical Chemistry, Vol. 47, Issue 3
https://doi.org/10.1021/ac60353a039

Development of the Implantable Glucose Sensor: What Are the Prospects and Why Is It Taking So Long?
journal, September 1995

Gough, D. A.; Armour, J. C.
Diabetes, Vol. 44, Issue 9
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Chiral discrimination of monosaccharides using a fluorescent molecular sensor
journal, March 1995

James, Tony D.; Samankumara Sandanayake, K. R. A.; Shinkai, Seiji
Nature, Vol. 374, Issue 6520
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Fluorescence lifetime-based sensing of pH, Ca2+, K+ and glucose
journal, March 1993

Lakowicz, Joseph R.; Szmacinski, Henryk
Sensors and Actuators B: Chemical, Vol. 11, Issue 1-3
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Sugar-Assisted Chirality Control of Tris(2,2′-bipyridine)-Metal Complexes
journal, July 1994

Nakashima, Kazuaki; Shinkai, Seiji
Chemistry Letters, Vol. 23, Issue 7
https://doi.org/10.1246/cl.1994.1267

Microporous membrane flow cell with nonimmobilized enzyme for chemiluminescent determination of glucose
journal, September 1982

Pilosof, David.; Nieman, Timothy A.
Analytical Chemistry, Vol. 54, Issue 11
https://doi.org/10.1021/ac00248a010

Near-infrared spectroscopic measurement of glucose in a protein matrix
journal, November 1993

Marquardt, Lois A.; Arnold, Mark A.; Small, Gary W.
Analytical Chemistry, Vol. 65, Issue 22
https://doi.org/10.1021/ac00070a018

Homovanillic acid as a fluorometric substrate for oxidative enzymes. Analytical applications of the peroxidase, glucose oxidase, and xanthine oxidase systems
journal, January 1968

Guilbault, George G.; Brignac, Paul J.; Zimmer, Mary.
Analytical Chemistry, Vol. 40, Issue 1
https://doi.org/10.1021/ac60257a002

Novel Saccharide-Photoinduced Electron Transfer Sensors Based on the Interaction of Boronic Acid and Amine
journal, September 1995

James, Tony D.; Sandanayake, K. R. A. Samankumara; Iguchi, Ritsuko
Journal of the American Chemical Society, Vol. 117, Issue 35
https://doi.org/10.1021/ja00140a013

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Detection of biological molecules using boronate-based chemical amplification and optical sensors

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Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
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Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
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Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
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Similar Records

Title: Detection of biological molecules using boronate-based chemical amplification and optical sensors

Abstract

Citation Formats

Purification and partial characterization of a mitogenic lectin from vicia sativa journal, March 1979

Arylboronic Acids. VI. Aminoboronic Anhydrides and a New Heterocycle Containing Boron 1,2 journal, August 1960

Aldehyde Syntheses. Study of the preparation of 9,10-anthracenedicarboxaldehyde journal, December 1979

Molecular Fluorescence Sensor for Saccharides Based on Amino Coumarin journal, February 1995

Fluorescent chemosensors of carbohydrates. A means of chemically communicating the binding of polyols in water based on chelation-enhanced quenching journal, July 1992

Determination of physiological levels of glucose in an aqueous matrix with digitally filtered Fourier transform near-infrared spectra journal, July 1990

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus journal, September 1993

Quantitative determination of blood glucose using enzyme induced chemiluminescence of luminol journal, March 1975

Development of the Implantable Glucose Sensor: What Are the Prospects and Why Is It Taking So Long? journal, September 1995

Chiral discrimination of monosaccharides using a fluorescent molecular sensor journal, March 1995

Fluorescence lifetime-based sensing of pH, Ca2+, K+ and glucose journal, March 1993

Sugar-Assisted Chirality Control of Tris(2,2′-bipyridine)-Metal Complexes journal, July 1994

Microporous membrane flow cell with nonimmobilized enzyme for chemiluminescent determination of glucose journal, September 1982

Near-infrared spectroscopic measurement of glucose in a protein matrix journal, November 1993

Homovanillic acid as a fluorometric substrate for oxidative enzymes. Analytical applications of the peroxidase, glucose oxidase, and xanthine oxidase systems journal, January 1968

Novel Saccharide-Photoinduced Electron Transfer Sensors Based on the Interaction of Boronic Acid and Amine journal, September 1995

Purification and partial characterization of a mitogenic lectin from vicia sativa
journal, March 1979

Arylboronic Acids. VI. Aminoboronic Anhydrides and a New Heterocycle Containing Boron ^1,2
journal, August 1960

Aldehyde Syntheses. Study of the preparation of 9,10-anthracenedicarboxaldehyde
journal, December 1979

Molecular Fluorescence Sensor for Saccharides Based on Amino Coumarin
journal, February 1995

Fluorescent chemosensors of carbohydrates. A means of chemically communicating the binding of polyols in water based on chelation-enhanced quenching
journal, July 1992

Determination of physiological levels of glucose in an aqueous matrix with digitally filtered Fourier transform near-infrared spectra
journal, July 1990

The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus
journal, September 1993

Quantitative determination of blood glucose using enzyme induced chemiluminescence of luminol
journal, March 1975

Development of the Implantable Glucose Sensor: What Are the Prospects and Why Is It Taking So Long?
journal, September 1995

Chiral discrimination of monosaccharides using a fluorescent molecular sensor
journal, March 1995

Fluorescence lifetime-based sensing of pH, Ca2+, K+ and glucose
journal, March 1993

Sugar-Assisted Chirality Control of Tris(2,2′-bipyridine)-Metal Complexes
journal, July 1994

Microporous membrane flow cell with nonimmobilized enzyme for chemiluminescent determination of glucose
journal, September 1982

Near-infrared spectroscopic measurement of glucose in a protein matrix
journal, November 1993

Homovanillic acid as a fluorometric substrate for oxidative enzymes. Analytical applications of the peroxidase, glucose oxidase, and xanthine oxidase systems
journal, January 1968

Novel Saccharide-Photoinduced Electron Transfer Sensors Based on the Interaction of Boronic Acid and Amine
journal, September 1995