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Title: Detection of biological molecules using boronate-based chemical amplification and optical sensors

Abstract

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.

Inventors:
; ; ; ; ; ;
Issue Date:
Research Org.:
MiniMed Inc., Sylmar, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174901
Patent Number(s):
6750311
Application Number:
09/461,627
Assignee:
MiniMed Inc. (Sylmar, CA)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M., Satcher, Jr., Joe H., Darrow, Christopher B., Peyser, Thomas A., and Harder, Jennifer. Detection of biological molecules using boronate-based chemical amplification and optical sensors. United States: N. p., 2004. Web.
Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M., Satcher, Jr., Joe H., Darrow, Christopher B., Peyser, Thomas A., & Harder, Jennifer. Detection of biological molecules using boronate-based chemical amplification and optical sensors. United States.
Van Antwerp, William Peter, Mastrototaro, John Joseph, Lane, Stephen M., Satcher, Jr., Joe H., Darrow, Christopher B., Peyser, Thomas A., and Harder, Jennifer. Tue . "Detection of biological molecules using boronate-based chemical amplification and optical sensors". United States. https://www.osti.gov/servlets/purl/1174901.
@article{osti_1174901,
title = {Detection of biological molecules using boronate-based chemical amplification and optical sensors},
author = {Van Antwerp, William Peter and Mastrototaro, John Joseph and Lane, Stephen M. and Satcher, Jr., Joe H. and Darrow, Christopher B. and Peyser, Thomas A. and Harder, Jennifer},
abstractNote = {Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {6}
}

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Works referenced in this record:

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