Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform

Chen, Liaohai

Title: Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform

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Abstract

The present invention provides a method of detecting a biological agent including contacting a sample with a sensor including a polymer system capable of having an alterable measurable property from the group of luminescence, anisotropy, redox potential and uv/vis absorption, the polymer system including an ionic conjugated polymer and an electronically inert polyelectrolyte having a biological agent recognition element bound thereto, the electronically inert polyelectrolyte adapted for undergoing a conformational structural change upon exposure to a biological agent having affinity for binding to the recognition element bound to the electronically inert polyelectrolyte, and, detecting the detectable change in the alterable measurable property. A chemical moiety being the reaction product of (i) a polyelectrolyte monomer and (ii) a biological agent recognition element-substituted polyelectrolyte monomer is also provided.

Inventors:: Chen, Liaohai

Issue Date:: 2004-05-18

Research Org.:: The Regents of the University of California, Los Alamos, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1174849

Patent Number(s):: 6737279

Application Number:: 09/820,402

Assignee:: University Of California, The Regents Of

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/54393 - {Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding}

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DOE Contract Number:: W-7405-ENG-36

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 47 OTHER INSTRUMENTATION

Citation Formats


                    Chen, Liaohai. Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform.  United States: N. p., 2004. 
        Web.

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                    Chen, Liaohai. Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform.  United States.

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                    Chen, Liaohai. Tue .  
        "Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform".  United States.  https://www.osti.gov/servlets/purl/1174849.

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@article{osti_1174849,

  title        = {Tuning the properties of conjugated polyelectrolytes and application in a biosensor platform},

  author       = {Chen, Liaohai},

  abstractNote = {The present invention provides a method of detecting a biological agent including contacting a sample with a sensor including a polymer system capable of having an alterable measurable property from the group of luminescence, anisotropy, redox potential and uv/vis absorption, the polymer system including an ionic conjugated polymer and an electronically inert polyelectrolyte having a biological agent recognition element bound thereto, the electronically inert polyelectrolyte adapted for undergoing a conformational structural change upon exposure to a biological agent having affinity for binding to the recognition element bound to the electronically inert polyelectrolyte, and, detecting the detectable change in the alterable measurable property. A chemical moiety being the reaction product of (i) a polyelectrolyte monomer and (ii) a biological agent recognition element-substituted polyelectrolyte monomer is also provided.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2004},

  month        = {5}

}

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