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Title: Ion sensing method

Abstract

The present invention allows the determination of trace levels of ionic substances in a sample solution (ions, metal ions, and other electrically charged molecules) by coupling a separation method, such as liquid chromatography, with ion selective electrodes (ISE) prepared so as to allow detection at activities below 10.sup.-6 M. The separation method distributes constituent molecules into fractions due to unique chemical and physical properties, such as charge, hydrophobicity, specific binding interactions, or movement in an electrical field. The separated fractions are detected by means of the ISE(s). These ISEs can be used singly or in an array. Accordingly, modifications in the ISEs are used to permit detection of low activities, specifically, below 10.sup.-6 M, by using low activities of the primary analyte (the molecular species which is specifically detected) in the inner filling solution of the ISE. Arrays constructed in various ways allow flow-through sensing for multiple ions.

Inventors:
;
Issue Date:
Research Org.:
IA INC, Ann Arbor, MI (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174847
Patent Number(s):
6736958
Application Number:
09/836,542
Assignee:
IA INC (Ann Arbor, MI)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
FG02-00ER83019
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Smith, Richard Harding, and Martin, Glenn Brian. Ion sensing method. United States: N. p., 2004. Web.
Smith, Richard Harding, & Martin, Glenn Brian. Ion sensing method. United States.
Smith, Richard Harding, and Martin, Glenn Brian. Tue . "Ion sensing method". United States. https://www.osti.gov/servlets/purl/1174847.
@article{osti_1174847,
title = {Ion sensing method},
author = {Smith, Richard Harding and Martin, Glenn Brian},
abstractNote = {The present invention allows the determination of trace levels of ionic substances in a sample solution (ions, metal ions, and other electrically charged molecules) by coupling a separation method, such as liquid chromatography, with ion selective electrodes (ISE) prepared so as to allow detection at activities below 10.sup.-6 M. The separation method distributes constituent molecules into fractions due to unique chemical and physical properties, such as charge, hydrophobicity, specific binding interactions, or movement in an electrical field. The separated fractions are detected by means of the ISE(s). These ISEs can be used singly or in an array. Accordingly, modifications in the ISEs are used to permit detection of low activities, specifically, below 10.sup.-6 M, by using low activities of the primary analyte (the molecular species which is specifically detected) in the inner filling solution of the ISE. Arrays constructed in various ways allow flow-through sensing for multiple ions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {5}
}

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Works referenced in this record:

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journal, September 1997


Nonlinear calibration of ion-selective electrode arrays for flow injection analysis
journal, August 1992


Determination of monovalent cations by ion chromatography with ion-selective electrode detection
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Potentiometric pH detection in suppressed ion chromatography
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Fast determination of anions by computerized ion chromatography coupled with selective detectors
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journal, March 1999


Direct and replacement ion chromatography with potentiometric detection using a silver/silver bromide electrode
journal, January 1989


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journal, October 1993


Replacement ion chromatography with potentiometric detection using a potassium-selective membrane electrode
journal, January 1989


Lead-selective bulk optodes based on neutral ionophores with subnanomolar detection limits
journal, July 1992