DNA mobility modifier

Barron, Annelise E.

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A - human necessities
A01 - agriculture
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Title: DNA mobility modifier

Abstract

Polyamides comprising at least one hydrophilic C.sub.1 -C.sub.10 hydrocarbyl substituent on an amide nitrogen atom, and methods for producing and using the same is provided. In particular, polyamides of the formula: ##STR1## and methods for using the same for altering the ratio of charge/translational frictional drag of binding polymers to allow electrophoretic separation of polynucleotides or analogs thereof in a non-sieving liquid medium is provided, where a, q, L.sup.1, P.sup.1, Q.sup.1, R, R.sup.1, R.sup.10 and R.sup.11 are those described herein.

Inventors:: Barron, Annelise E.

Issue Date:: 2004-04-20

Research Org.:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1174816

Patent Number(s):: 6723515

Application Number:: 10/197,613

Assignee:: Northwestern University (Evanston, IL)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS

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B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
C07H19/00 - Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical
C07H21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07H21/02 - with ribosyl as saccharide radical

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/68 - involving nucleic acids
C12Q1/6869 - Methods for sequencing
C12Q2525/203 - incorporating a composite nucleic acid containing a polypeptide sequence other than PNA
C12Q2565/125 - Electrophoretic separation

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DOE Contract Number:: FR02-99ER62789

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Barron, Annelise E. DNA mobility modifier.  United States: N. p., 2004. 
        Web.

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                    Barron, Annelise E. DNA mobility modifier.  United States.

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                    Barron, Annelise E. Tue .  
        "DNA mobility modifier".  United States.  https://www.osti.gov/servlets/purl/1174816.

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@article{osti_1174816,

  title        = {DNA mobility modifier},

  author       = {Barron, Annelise E.},

  abstractNote = {Polyamides comprising at least one hydrophilic C.sub.1 -C.sub.10 hydrocarbyl substituent on an amide nitrogen atom, and methods for producing and using the same is provided. In particular, polyamides of the formula: ##STR1## and methods for using the same for altering the ratio of charge/translational frictional drag of binding polymers to allow electrophoretic separation of polynucleotides or analogs thereof in a non-sieving liquid medium is provided, where a, q, L.sup.1, P.sup.1, Q.sup.1, R, R.sup.1, R.sup.10 and R.sup.11 are those described herein.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2004},

  month        = {4}

}

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Works referenced in this record:

[25] Synthesis of N-substituted glycine peptoid libraries
book, January 1996

Figliozzi, Gianine M.; Goldsmith, Richard; Ng, Simon C.
Combinatorial Chemistry
https://doi.org/10.1016/S0076-6879(96)67027-X

Free-solution electrophoresis of DNA
journal, May 1998

Heller, Christoph; Slater, Gary W.; Mayer, Pascal
Journal of Chromatography A, Vol. 806, Issue 1
https://doi.org/10.1016/S0021-9673(97)00656-0

Theory of DNA Sequencing Using Free-Solution Electrophoresis of Protein-DNA Complexes
journal, May 1994

Mayer, Pascal.; Slater, Gary W.; Drouin, Guy.
Analytical Chemistry, Vol. 66, Issue 10
https://doi.org/10.1021/ac00082a029

Solid-Phase synthesis of peptide nucleic acids
journal, May 1995

Christensen, Leif; Fitzpatrick, Richard; Gildea, Brian
Journal of Peptide Science, Vol. 1, Issue 3
https://doi.org/10.1002/psc.310010304

Solid Phase Syntheses of Oligoureas
journal, February 1997

Burgess, Kevin; Ibarzo, Javier; Linthicum, D. Scott
Journal of the American Chemical Society, Vol. 119, Issue 7
https://doi.org/10.1021/ja9631256

A new concept for sequencing DNA by capillary electrophoresis
journal, January 1992

Noolandi, Jaan
Electrophoresis, Vol. 13, Issue 1
https://doi.org/10.1002/elps.1150130180

Impact of biophysical parameters on the biological assessment of peptide nucleic acids, antisense inhibitors of gene expression
journal, February 1995

Noble, Stewart A.; Bonham, Michele A.; Bisi, John E.
Drug Development Research, Vol. 34, Issue 2
https://doi.org/10.1002/ddr.430340208

Recent developments in DNA electrophoretic separations
journal, July 1998

Slater, Gary W.; Kist, Tarso B. L.; Ren, Hongji
Electrophoresis, Vol. 19, Issue 10
https://doi.org/10.1002/elps.1150191003

Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library
journal, August 1994

Zuckermann, Ronald N.; Martin, Eric J.; Spellmeyer, David C.
Journal of Medicinal Chemistry, Vol. 37, Issue 17
https://doi.org/10.1021/jm00043a007

Separating DNA sequencing fragments without a sieving matrix
journal, August 1999

Ren, Hongji; Karger, Achim E.; Oaks, Frank
Electrophoresis, Vol. 20, Issue 12, p. 2501-2509
URL: 10.1002/(SICI)1522-2683(19990801)20:12<2501::AID-ELPS2501>3.0.CO;2-H

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
journal, December 1992

Zuckermann, Ronald N.; Kerr, Janice M.; Kent, Stephen B. H.
Journal of the American Chemical Society, Vol. 114, Issue 26
https://doi.org/10.1021/ja00052a076

Electrophoretic mobility of composite objects in free solution: Application to DNA separation
journal, January 1996

Long, Didier; Ajdari, Armand
Electrophoresis, Vol. 17, Issue 6
https://doi.org/10.1002/elps.1150170628

Mobilities of Labeled and Unlabeled Single-Stranded DNA in Free Solution Electrophoresis
journal, November 1995

Voelkel, A. R.; Noolandi, J.
Macromolecules, Vol. 28, Issue 24
https://doi.org/10.1021/ma00128a031

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Polyamides comprising at least one hydrophilic C.sub.1 -C.sub.10 hydrocarbyl substituent on an amide nitrogen atom, and methods for producing and using the same is provided. In particular, polyamides of the formula: ##STR1## and methods for using the same for altering the ratio of charge/translational frictional drag of binding polymers to allow electrophoretic separation of polynucleotides or analogs thereof in a non-sieving liquid medium is provided, where a, q, L.sup.1, P.sup.1, Q.sup.1, R, R.sup.1, R.sup.10 and R.sup.11 are those described herein.
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Similar Records

Title: DNA mobility modifier

Abstract

Citation Formats

[25] Synthesis of N-substituted glycine peptoid libraries book, January 1996

Free-solution electrophoresis of DNA journal, May 1998

Theory of DNA Sequencing Using Free-Solution Electrophoresis of Protein-DNA Complexes journal, May 1994

Solid-Phase synthesis of peptide nucleic acids journal, May 1995

Solid Phase Syntheses of Oligoureas journal, February 1997

A new concept for sequencing DNA by capillary electrophoresis journal, January 1992

Impact of biophysical parameters on the biological assessment of peptide nucleic acids, antisense inhibitors of gene expression journal, February 1995

Recent developments in DNA electrophoretic separations journal, July 1998

Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library journal, August 1994

Separating DNA sequencing fragments without a sieving matrix journal, August 1999

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis journal, December 1992

Electrophoretic mobility of composite objects in free solution: Application to DNA separation journal, January 1996

Mobilities of Labeled and Unlabeled Single-Stranded DNA in Free Solution Electrophoresis journal, November 1995

[25] Synthesis of N-substituted glycine peptoid libraries
book, January 1996

Free-solution electrophoresis of DNA
journal, May 1998

Theory of DNA Sequencing Using Free-Solution Electrophoresis of Protein-DNA Complexes
journal, May 1994

Solid-Phase synthesis of peptide nucleic acids
journal, May 1995

Solid Phase Syntheses of Oligoureas
journal, February 1997

A new concept for sequencing DNA by capillary electrophoresis
journal, January 1992

Impact of biophysical parameters on the biological assessment of peptide nucleic acids, antisense inhibitors of gene expression
journal, February 1995

Recent developments in DNA electrophoretic separations
journal, July 1998

Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library
journal, August 1994

Separating DNA sequencing fragments without a sieving matrix
journal, August 1999

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
journal, December 1992

Electrophoretic mobility of composite objects in free solution: Application to DNA separation
journal, January 1996

Mobilities of Labeled and Unlabeled Single-Stranded DNA in Free Solution Electrophoresis
journal, November 1995