skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: DNA mobility modifier

Abstract

Polyamides comprising at least one hydrophilic C.sub.1 -C.sub.10 hydrocarbyl substituent on an amide nitrogen atom, and methods for producing and using the same is provided. In particular, polyamides of the formula: ##STR1## and methods for using the same for altering the ratio of charge/translational frictional drag of binding polymers to allow electrophoretic separation of polynucleotides or analogs thereof in a non-sieving liquid medium is provided, where a, q, L.sup.1, P.sup.1, Q.sup.1, R, R.sup.1, R.sup.10 and R.sup.11 are those described herein.

Inventors:
Issue Date:
Research Org.:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174816
Patent Number(s):
6723515
Application Number:
10/197,613
Assignee:
Northwestern University (Evanston, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
DOE Contract Number:  
FR02-99ER62789
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Barron, Annelise E. DNA mobility modifier. United States: N. p., 2004. Web.
Barron, Annelise E. DNA mobility modifier. United States.
Barron, Annelise E. Tue . "DNA mobility modifier". United States. https://www.osti.gov/servlets/purl/1174816.
@article{osti_1174816,
title = {DNA mobility modifier},
author = {Barron, Annelise E.},
abstractNote = {Polyamides comprising at least one hydrophilic C.sub.1 -C.sub.10 hydrocarbyl substituent on an amide nitrogen atom, and methods for producing and using the same is provided. In particular, polyamides of the formula: ##STR1## and methods for using the same for altering the ratio of charge/translational frictional drag of binding polymers to allow electrophoretic separation of polynucleotides or analogs thereof in a non-sieving liquid medium is provided, where a, q, L.sup.1, P.sup.1, Q.sup.1, R, R.sup.1, R.sup.10 and R.sup.11 are those described herein.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {4}
}

Patent:

Save / Share:

Works referenced in this record:

Free-solution electrophoresis of DNA
journal, May 1998


Theory of DNA Sequencing Using Free-Solution Electrophoresis of Protein-DNA Complexes
journal, May 1994


Solid-Phase synthesis of peptide nucleic acids
journal, May 1995


Solid Phase Syntheses of Oligoureas
journal, February 1997


A new concept for sequencing DNA by capillary electrophoresis
journal, January 1992


Impact of biophysical parameters on the biological assessment of peptide nucleic acids, antisense inhibitors of gene expression
journal, February 1995


Recent developments in DNA electrophoretic separations
journal, July 1998


Discovery of Nanomolar Ligands for 7-Transmembrane G-Protein-Coupled Receptors from a Diverse N-(Substituted)glycine Peptoid Library
journal, August 1994


Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
journal, December 1992


Electrophoretic mobility of composite objects in free solution: Application to DNA separation
journal, January 1996


Mobilities of Labeled and Unlabeled Single-Stranded DNA in Free Solution Electrophoresis
journal, November 1995