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Title: Patterned substrates and methods for nerve regeneration

Abstract

Micropatterned substrates and methods for fabrication of artificial nerve regeneration conduits and methods for regenerating nerves are provided. Guidance compounds or cells are seeded in grooves formed on the patterned substrate. The substrates may also be provided with electrodes to provide electrical guidance cues to the regenerating nerve. The micropatterned substrates give physical, chemical, cellular and/or electrical guidance cues to promote nerve regeneration at the cellular level.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Iowa State Univ., Ames, IA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174676
Patent Number(s):
6676675
Application Number:
09/837,303
Assignee:
Iowa State University Research Foundation, Inc. (Ames, IA)
Patent Classifications (CPCs):
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
W-7405-ENG-82
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Mallapragada, Surya K., Heath, Carole, Shanks, Howard, Miller, Cheryl A., and Jeftinija, Srdija. Patterned substrates and methods for nerve regeneration. United States: N. p., 2004. Web.
Mallapragada, Surya K., Heath, Carole, Shanks, Howard, Miller, Cheryl A., & Jeftinija, Srdija. Patterned substrates and methods for nerve regeneration. United States.
Mallapragada, Surya K., Heath, Carole, Shanks, Howard, Miller, Cheryl A., and Jeftinija, Srdija. Tue . "Patterned substrates and methods for nerve regeneration". United States. https://www.osti.gov/servlets/purl/1174676.
@article{osti_1174676,
title = {Patterned substrates and methods for nerve regeneration},
author = {Mallapragada, Surya K. and Heath, Carole and Shanks, Howard and Miller, Cheryl A. and Jeftinija, Srdija},
abstractNote = {Micropatterned substrates and methods for fabrication of artificial nerve regeneration conduits and methods for regenerating nerves are provided. Guidance compounds or cells are seeded in grooves formed on the patterned substrate. The substrates may also be provided with electrodes to provide electrical guidance cues to the regenerating nerve. The micropatterned substrates give physical, chemical, cellular and/or electrical guidance cues to promote nerve regeneration at the cellular level.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2004},
month = {1}
}

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Works referenced in this record:

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