Title: Patterned substrates and methods for nerve regeneration

Abstract

Micropatterned substrates and methods for fabrication of artificial nerve regeneration conduits and methods for regenerating nerves are provided. Guidance compounds or cells are seeded in grooves formed on the patterned substrate. The substrates may also be provided with electrodes to provide electrical guidance cues to the regenerating nerve. The micropatterned substrates give physical, chemical, cellular and/or electrical guidance cues to promote nerve regeneration at the cellular level.

Inventors:

Mallapragada, Surya K.; Heath, Carole; Shanks, Howard; Miller, Cheryl A.; Jeftinija, Srdija

Issue Date:

Tue Jan 13 00:00:00 EST 2004

Research Org.:

Iowa State Univ., Ames, IA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1174676

Patent Number(s):

6676675

Application Number:

09/837,303

Assignee:

Iowa State University Research Foundation, Inc. (Ames, IA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K35/12 - Materials from mammals

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

A61L2430/32 - for nerve reconstruction
A61L27/18 - obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L27/3821 - {Bone-forming cells, e.g. osteoblasts, osteocytes, osteoprogenitor cells}
A61L27/383 - {Nerve cells, e.g. dendritic cells, Schwann cells}
A61L27/56 - Porous materials, {e.g. foams or sponges}
A61L31/06 - obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {
A61L31/146 - {Porous materials, e.g. foams or sponges}

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS

C08L67/04 - Polyesters derived from hydroxycarboxylic acids, e.g. lactones

C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY

C12M21/08 - {for producing artificial tissue or for ex-vivo cultivation of tissue
C12M25/08 - {electrically charged}

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N2502/08 - cells of the nervous system
C12N2533/40 - Polyhydroxyacids, e.g. polymers of glycolic or lactic acid
C12N2535/10 - Patterned coating
C12N5/0068 - {General culture methods using substrates
C12N5/0619 - {Neurons}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

Y10S977/701 - Integrated with dissimilar structures on a common substrate
Y10S977/796 - for electrical or electronic purpose

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DOE Contract Number:  

W-7405-ENG-82

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES