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Title: Multiple stimulus reversible hydrogels

Abstract

A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.

Inventors:
;
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174611
Patent Number(s):
6660247
Application Number:
09/603,730
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Gutowska, Anna, and Krzyminski, Karol J. Multiple stimulus reversible hydrogels. United States: N. p., 2003. Web.
Gutowska, Anna, & Krzyminski, Karol J. Multiple stimulus reversible hydrogels. United States.
Gutowska, Anna, and Krzyminski, Karol J. Tue . "Multiple stimulus reversible hydrogels". United States. https://www.osti.gov/servlets/purl/1174611.
@article{osti_1174611,
title = {Multiple stimulus reversible hydrogels},
author = {Gutowska, Anna and Krzyminski, Karol J.},
abstractNote = {A polymeric solution capable of gelling upon exposure to a critical minimum value of a plurality of environmental stimuli is disclosed. The polymeric solution may be an aqueous solution utilized in vivo and capable of having the gelation reversed if at least one of the stimuli fall below, or outside the range of, the critical minimum value. The aqueous polymeric solution can be used either in industrial or pharmaceutical environments. In the medical environment, the aqueous polymeric solution is provided with either a chemical or radioisotopic therapeutic agent for delivery to a specific body part. The primary advantage of the process is that exposure to one environmental stimuli alone will not cause gelation, thereby enabling the therapeutic agent to be conducted through the body for relatively long distances without gelation occurring.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {12}
}

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Works referenced in this record:

Swelling equilibria for weakly ionizable, temperature-sensitive hydrogels
journal, March 1991


Temperature modulated protein release from pH/temperature-sensitive hydrogels
journal, March 1999


Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH
journal, January 1995