Method for high resolution magnetic resonance analysis using magic angle technique

Wind, Robert A.; Hu, Jian Zhi

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Title: Method for high resolution magnetic resonance analysis using magic angle technique

Abstract

A method of performing a magnetic resonance analysis of a biological object that includes placing the biological object in a main magnetic field and in a radio frequency field, the main magnetic field having a static field direction; rotating the biological object at a rotational frequency of less than about 100 Hz around an axis positioned at an angle of about 54.degree.44' relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. According to another embodiment, the radio frequency is pulsed to provide a sequence capable of producing a spectrum that is substantially free of spinning sideband peaks.

Inventors:: Wind, Robert A.; Hu, Jian Zhi

Issue Date:: 2003-11-25

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1174598

Patent Number(s):: 6653832

Application Number:: 09/803,381

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

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G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/307 - {specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer}
G01R33/54 - Signal processing systems, e.g. using pulse sequences {, Generation or control of pulse sequences

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DOE Contract Number:: AC06-76RL01830

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats


                    Wind, Robert A., and Hu, Jian Zhi. Method for high resolution magnetic resonance analysis using magic angle technique.  United States: N. p., 2003. 
        Web.

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                    Wind, Robert A., & Hu, Jian Zhi. Method for high resolution magnetic resonance analysis using magic angle technique.  United States.

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                    Wind, Robert A., and Hu, Jian Zhi. Tue .  
        "Method for high resolution magnetic resonance analysis using magic angle technique".  United States.  https://www.osti.gov/servlets/purl/1174598.

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@article{osti_1174598,

  title        = {Method for high resolution magnetic resonance analysis using magic angle technique},

  author       = {Wind, Robert A. and Hu, Jian Zhi},

  abstractNote = {A method of performing a magnetic resonance analysis of a biological object that includes placing the biological object in a main magnetic field and in a radio frequency field, the main magnetic field having a static field direction; rotating the biological object at a rotational frequency of less than about 100 Hz around an axis positioned at an angle of about 54.degree.44' relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. According to another embodiment, the radio frequency is pulsed to provide a sequence capable of producing a spectrum that is substantially free of spinning sideband peaks.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2003},

  month        = {11}

}

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Works referenced in this record:

Two-Dimensional Sideband Separation in Magic-Angle-Spinning NMR
journal, July 1995

Antzutkin, O. N.; Shekar, S. C.; Levitt, M. H.
Journal of Magnetic Resonance, Series A, Vol. 115, Issue 1
https://doi.org/10.1006/jmra.1995.1142

High-resolution chemical shift and chemical shift anisotropy correlation in solids using slow magic angle spinning
journal, October 1992

Gan, Zhehong
Journal of the American Chemical Society, Vol. 114, Issue 21
https://doi.org/10.1021/ja00047a062

Fluorine-19 Solid-State NMR Magic-Angle-Turning Experiments Using Multiple-Pulse Homonuclear Decoupling
journal, June 1999

Hughes, Eric; Brouwer, Eric B.; Harris, Robin K.
Journal of Magnetic Resonance, Vol. 138, Issue 2
https://doi.org/10.1006/jmre.1999.1740

Magic-Angle-Turning Experiments for Measuring Chemical-Shift-Tensor Principal Values in Powdered Solids
journal, April 1995

Hu, J. Z.; Wang, W.; Liu, F.
Journal of Magnetic Resonance, Series A, Vol. 113, Issue 2
https://doi.org/10.1006/jmra.1995.1082

Gradient, high-resolution, magic angle spinning1H nuclear magnetic resonance spectroscopy of intact cells
journal, March 1998

Weybright, Patrick; Millis, Kevin; Campbell, Natalee
Magnetic Resonance in Medicine, Vol. 39, Issue 3
https://doi.org/10.1002/mrm.1910390302

Nuclear magnetic resonance in a rotating magnetic field
journal, March 1968

Bradbury, A.; Eades, R. G.; McCarten, J. G.
Physics Letters A, Vol. 26, Issue 9
https://doi.org/10.1016/0375-9601(68)90244-2

High-Resolution Magic Angle Spinning 1H NMR Spectroscopy of Intact Liver and Kidney: Optimization of Sample Preparation Procedures and Biochemical Stability of Tissue during Spectral Acquisition
journal, June 2000

Waters, N. J.; Garrod, S.; Farrant, R. D.
Analytical Biochemistry, Vol. 282, Issue 1
https://doi.org/10.1006/abio.2000.4574

Low-speed magic-angle-spinning carbon-13 NMR of fruit tissue
journal, September 1992

Ni, Qing Wen.; Eads, Thomas M.
Journal of Agricultural and Food Chemistry, Vol. 40, Issue 9
https://doi.org/10.1021/jf00021a007

A sensitive, high resolution magic angle turning experiment for measuring chemical shift tensor principal values
journal, December 1998

Alderman, D. W.; McGEORGE, Gary; Hu, Jian Zhi
Molecular Physics, Vol. 95, Issue 6
https://doi.org/10.1080/00268979809483243

Selective excitation in Fourier transform nuclear magnetic resonance
journal, March 1978

Morris, Gareth A.; Freeman, Ray
Journal of Magnetic Resonance (1969), Vol. 29, Issue 3
https://doi.org/10.1016/0022-2364(78)90003-3

An investigation of rat mammary healthy and R3230AC tumor tissues and cells by means of solid-state 13C NMR
journal, December 1996

Wind, R. A.; Concannon, B. A.; Groch, K. M.
Solid State Nuclear Magnetic Resonance, Vol. 7, Issue 3
https://doi.org/10.1016/S0926-2040(96)01262-3

Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy
journal, June 1997

Cheng, L. L.; Ma, M. J.; Becerra, L.
Proceedings of the National Academy of Sciences, Vol. 94, Issue 12
https://doi.org/10.1073/pnas.94.12.6408

Manipulation of phase and amplitude modulation of spin magnetization in magic angle spinning nuclear magnetic resonance in the presence of molecular diffusion
journal, April 2001

Liu, Yun; Leu, Gabriela; Singer, S.
The Journal of Chemical Physics, Vol. 114, Issue 13
https://doi.org/10.1063/1.1352620

Improvements to the magic angle hopping experiment
journal, October 1993

Hu, Jian Zhi; Orendt, Anita M.; Alderman, Donald W.
Solid State Nuclear Magnetic Resonance, Vol. 2, Issue 5
https://doi.org/10.1016/0926-2040(93)90003-6

High-resolution1H NMR spectroscopy in rat liver using magic angle turning at a 1 Hz spinning rate
journal, April 2002

Hu, Jian Zhi; Rommereim, Donald N.; Wind, Robert A.
Magnetic Resonance in Medicine, Vol. 47, Issue 5
https://doi.org/10.1002/mrm.10139

An Isotropic Chemical Shift-Chemical Shift Anisotropy Magic-Angle Slow-Spinning 2D NMR Experiment
journal, October 1993

Hu, J. Z.; Alderman, D. W.; Ye, C. H.
Journal of Magnetic Resonance, Series A, Vol. 105, Issue 1
https://doi.org/10.1006/jmra.1993.1252

Correlation of isotropic shifts and chemical shift anisotropies by two-dimensional fourier-transform magic-angle hopping nmr spectroscopy
journal, March 1983

Bax, Ad; Szeverenyi, Nikolaus M.; Maciel, Gary E.
Journal of Magnetic Resonance (1969), Vol. 52, Issue 1
https://doi.org/10.1016/0022-2364(83)90267-6

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Similar Records

Title: Method for high resolution magnetic resonance analysis using magic angle technique

Abstract

Citation Formats

Two-Dimensional Sideband Separation in Magic-Angle-Spinning NMR journal, July 1995

High-resolution chemical shift and chemical shift anisotropy correlation in solids using slow magic angle spinning journal, October 1992

Fluorine-19 Solid-State NMR Magic-Angle-Turning Experiments Using Multiple-Pulse Homonuclear Decoupling journal, June 1999

Magic-Angle-Turning Experiments for Measuring Chemical-Shift-Tensor Principal Values in Powdered Solids journal, April 1995

Gradient, high-resolution, magic angle spinning1H nuclear magnetic resonance spectroscopy of intact cells journal, March 1998

Nuclear magnetic resonance in a rotating magnetic field journal, March 1968

High-Resolution Magic Angle Spinning 1H NMR Spectroscopy of Intact Liver and Kidney: Optimization of Sample Preparation Procedures and Biochemical Stability of Tissue during Spectral Acquisition journal, June 2000

Low-speed magic-angle-spinning carbon-13 NMR of fruit tissue journal, September 1992

A sensitive, high resolution magic angle turning experiment for measuring chemical shift tensor principal values journal, December 1998

Selective excitation in Fourier transform nuclear magnetic resonance journal, March 1978

An investigation of rat mammary healthy and R3230AC tumor tissues and cells by means of solid-state 13C NMR journal, December 1996

Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy journal, June 1997

Manipulation of phase and amplitude modulation of spin magnetization in magic angle spinning nuclear magnetic resonance in the presence of molecular diffusion journal, April 2001

Improvements to the magic angle hopping experiment journal, October 1993

High-resolution1H NMR spectroscopy in rat liver using magic angle turning at a 1 Hz spinning rate journal, April 2002

An Isotropic Chemical Shift-Chemical Shift Anisotropy Magic-Angle Slow-Spinning 2D NMR Experiment journal, October 1993

Correlation of isotropic shifts and chemical shift anisotropies by two-dimensional fourier-transform magic-angle hopping nmr spectroscopy journal, March 1983

Two-Dimensional Sideband Separation in Magic-Angle-Spinning NMR
journal, July 1995

High-resolution chemical shift and chemical shift anisotropy correlation in solids using slow magic angle spinning
journal, October 1992

Fluorine-19 Solid-State NMR Magic-Angle-Turning Experiments Using Multiple-Pulse Homonuclear Decoupling
journal, June 1999

Magic-Angle-Turning Experiments for Measuring Chemical-Shift-Tensor Principal Values in Powdered Solids
journal, April 1995

Gradient, high-resolution, magic angle spinning1H nuclear magnetic resonance spectroscopy of intact cells
journal, March 1998

Nuclear magnetic resonance in a rotating magnetic field
journal, March 1968

High-Resolution Magic Angle Spinning 1H NMR Spectroscopy of Intact Liver and Kidney: Optimization of Sample Preparation Procedures and Biochemical Stability of Tissue during Spectral Acquisition
journal, June 2000

Low-speed magic-angle-spinning carbon-13 NMR of fruit tissue
journal, September 1992

A sensitive, high resolution magic angle turning experiment for measuring chemical shift tensor principal values
journal, December 1998

Selective excitation in Fourier transform nuclear magnetic resonance
journal, March 1978

An investigation of rat mammary healthy and R3230AC tumor tissues and cells by means of solid-state 13C NMR
journal, December 1996

Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy
journal, June 1997

Manipulation of phase and amplitude modulation of spin magnetization in magic angle spinning nuclear magnetic resonance in the presence of molecular diffusion
journal, April 2001

Improvements to the magic angle hopping experiment
journal, October 1993

High-resolution1H NMR spectroscopy in rat liver using magic angle turning at a 1 Hz spinning rate
journal, April 2002

An Isotropic Chemical Shift-Chemical Shift Anisotropy Magic-Angle Slow-Spinning 2D NMR Experiment
journal, October 1993

Correlation of isotropic shifts and chemical shift anisotropies by two-dimensional fourier-transform magic-angle hopping nmr spectroscopy
journal, March 1983