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Title: Detection of birefringent microcrystals in bile

Abstract

A transparent flow channel fluidly communicates a fluid source and a collection reservoir. A light beam passes through a first polarizer having a first plane of polarization. The flow channel is orthogonal to the light beam. The light beam passes through a fluid sample as it flows through the flow channel. The light beam is then filtered through a second polarizer having a second plane of polarization rotated 90.degree. from the first plane of polarization. The birefringence of certain crystalline materials present in the fluid sample rotates the plane of polarization of the light beam. The presence of these microcrystals thus causes a component of the beam to pass through the second polarizer and impinge an electronic photo-detector located in the path of the beam. The photo-detector signals the presence of the microcrystals by generating voltage pulses. A display device visually presents the quantitative results of the assay.

Inventors:
; ;
Issue Date:
Research Org.:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174518
Patent Number(s):
6,628,388
Application Number:
09/815,087
Assignee:
The Regents of the University of California (Oakland, CA) OSTI
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; 36 MATERIALS SCIENCE

Citation Formats

Darrow, Chris, Mirhej, Andrew, and Seger, Tino. Detection of birefringent microcrystals in bile. United States: N. p., 2003. Web.
Darrow, Chris, Mirhej, Andrew, & Seger, Tino. Detection of birefringent microcrystals in bile. United States.
Darrow, Chris, Mirhej, Andrew, and Seger, Tino. Tue . "Detection of birefringent microcrystals in bile". United States. https://www.osti.gov/servlets/purl/1174518.
@article{osti_1174518,
title = {Detection of birefringent microcrystals in bile},
author = {Darrow, Chris and Mirhej, Andrew and Seger, Tino},
abstractNote = {A transparent flow channel fluidly communicates a fluid source and a collection reservoir. A light beam passes through a first polarizer having a first plane of polarization. The flow channel is orthogonal to the light beam. The light beam passes through a fluid sample as it flows through the flow channel. The light beam is then filtered through a second polarizer having a second plane of polarization rotated 90.degree. from the first plane of polarization. The birefringence of certain crystalline materials present in the fluid sample rotates the plane of polarization of the light beam. The presence of these microcrystals thus causes a component of the beam to pass through the second polarizer and impinge an electronic photo-detector located in the path of the beam. The photo-detector signals the presence of the microcrystals by generating voltage pulses. A display device visually presents the quantitative results of the assay.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {9}
}

Patent:

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