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Title: Dual manifold system and method for fluid transfer

Abstract

A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.

Inventors:
; ;
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174511
Patent Number(s):
6,627,157
Application Number:
09/262,455
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ORNL
DOE Contract Number:  
AC05-96OR22464
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Doktycz, Mitchel J., Bryan, William Louis, and Kress, Reid. Dual manifold system and method for fluid transfer. United States: N. p., 2003. Web.
Doktycz, Mitchel J., Bryan, William Louis, & Kress, Reid. Dual manifold system and method for fluid transfer. United States.
Doktycz, Mitchel J., Bryan, William Louis, and Kress, Reid. Tue . "Dual manifold system and method for fluid transfer". United States. https://www.osti.gov/servlets/purl/1174511.
@article{osti_1174511,
title = {Dual manifold system and method for fluid transfer},
author = {Doktycz, Mitchel J. and Bryan, William Louis and Kress, Reid},
abstractNote = {A dual-manifold assembly is provided for the rapid, parallel transfer of liquid reagents from a microtiter plate to a solid state microelectronic device having biological sensors integrated thereon. The assembly includes aspiration and dispense manifolds connected by a plurality of conduits. In operation, the aspiration manifold is actuated such that the aspiration manifold is seated onto an array of reagent-filled wells of the microtiter plate. The wells are pressurized to force reagent through conduits toward the dispense manifold. A pressure pulse provided by a standard ink-jet printhead ejects nanoliter-to-picoliter droplets of reagent through an array of printhead orifices and onto test sites on the surface of the microelectronic device.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {9}
}

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