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Title: Microbial production of epoxides

Abstract

A method for microbial production of epoxides and other oxygenated products is disclosed. The method uses a biocatalyst of methanotrophic bacteria cultured in a biphasic medium containing a major amount of a non-aqueous polar solvent. Regeneration of reducing equivalents is carried out by using endogenous hydrogenase activity together with supplied hydrogen gas. This method is especially effective with gaseous substrates and cofactors that result in liquid products.

Inventors:
;
Issue Date:
Research Org.:
Idaho National Lab. (INL), Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174365
Patent Number(s):
6576449
Application Number:
09/805,795
Assignee:
Bechtel BWXT Idaho, LLC (Idaho Falls, ID)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
AC07-94ID13223
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Clark, Thomas R., and Roberto, Francisco F. Microbial production of epoxides. United States: N. p., 2003. Web.
Clark, Thomas R., & Roberto, Francisco F. Microbial production of epoxides. United States.
Clark, Thomas R., and Roberto, Francisco F. Tue . "Microbial production of epoxides". United States. https://www.osti.gov/servlets/purl/1174365.
@article{osti_1174365,
title = {Microbial production of epoxides},
author = {Clark, Thomas R. and Roberto, Francisco F.},
abstractNote = {A method for microbial production of epoxides and other oxygenated products is disclosed. The method uses a biocatalyst of methanotrophic bacteria cultured in a biphasic medium containing a major amount of a non-aqueous polar solvent. Regeneration of reducing equivalents is carried out by using endogenous hydrogenase activity together with supplied hydrogen gas. This method is especially effective with gaseous substrates and cofactors that result in liquid products.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {6}
}

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Works referenced in this record:

Biocatalysis in water-organic solvent two-phase systems
journal, July 1984


Selection of Xenobiotic-Degrading Microorganisms in a Biphasic Aqueous-Organic System
journal, January 1993


Methylosinus trichosporium OB3b whole-cell methane monooxygenase activity in a biphasic matrix
journal, June 1996


Technical and economic evaluation of different reactors for methanotrophic cultures for propylene oxide production
journal, August 1998