Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
Abstract
The present invention covers halogenated derivatives of boronated porphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron- capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1174335
- Patent Number(s):
- 6566517
- Application Number:
- 09/874,203
- Assignee:
- Brookhaven Science Associates, LLC (Upton, NY)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
Citation Formats
Miura, Michiko, and Slatkin, Daniel N. Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy. United States: N. p., 2003.
Web.
Miura, Michiko, & Slatkin, Daniel N. Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy. United States.
Miura, Michiko, and Slatkin, Daniel N. Tue .
"Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy". United States. https://www.osti.gov/servlets/purl/1174335.
@article{osti_1174335,
title = {Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy},
author = {Miura, Michiko and Slatkin, Daniel N.},
abstractNote = {The present invention covers halogenated derivatives of boronated porphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron- capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 20 00:00:00 EDT 2003},
month = {Tue May 20 00:00:00 EDT 2003}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Octabromotetraphenylporphyrin and its metal derivatives: Electronic structure and electrochemical properties
journal, January 1991
- Bhyrappa, P.; Krishnan, V.
- Inorganic Chemistry, Vol. 30, Issue 2
19F NMR Spectra and Structures of Halogenated Porphyrins
journal, July 1995
- Birnbaum, Eva R.; Hodge, Julia A.; Grinstaff, Mark W.
- Inorganic Chemistry, Vol. 34, Issue 14
In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer
journal, November 1999
- Miller, Richard A.; Woodburn, Kathryn; Fan, Qing
- International Journal of Radiation Oncology*Biology*Physics, Vol. 45, Issue 4
New Metalloporphyrins with Extremely Altered Redox Properties: Synthesis, Structure, and Facile Reduction to Air-Stable π-Anion Radicals of Zinc and Nickel β-Heptanitroporphyrins
journal, July 1997
- Ozette, Karine; Leduc, Philippe; Palacio, Magali
- Journal of the American Chemical Society, Vol. 119, Issue 27
Current status of 10B-neutron capture therapy: Enhancement of tumor dose via beam filtration and dose rate, and the effects of these parameters on minimum boron content: A theoretical evaluation
journal, April 1985
- Fairchild, R. G.; Bond, V. P.
- International Journal of Radiation Oncology*Biology*Physics, Vol. 11, Issue 4
2,3,7,8,12,13,17,18-Octafluoro-5,10,15,20-tetraarylporphyrins and Their Zinc Complexes: First Spectroscopic, Electrochemical, and Structural Characterization of a Perfluorinated Tetraarylmetalloporphyrin
journal, March 1997
- Woller, Eric K.; DiMagno, Stephen G.
- The Journal of Organic Chemistry, Vol. 62, Issue 6
Evaluation of carborane-containing porphyrins as tumour targeting agents for boron neutron capture therapy.
journal, July 1998
- Miura, M.; Micca, P. L.; Fisher, C. D.
- The British Journal of Radiology, Vol. 71, Issue 847
Boron Neutron Capture Therapy for Glioblastoma Multiforme: Interim Results from the Phase I/II Dose-Escalation Studies
journal, June 1999
- Chanana, Arjun D.; Capala,, Jacek; Chadha, Manjeet
- Neurosurgery, Vol. 44, Issue 6
A Straightforward Synthesis of 3,4-Difluoropyrrole
journal, August 1998
- Woller, Eric K.; Smirnov, Valeriy V.; DiMagno, Stephen G.
- The Journal of Organic Chemistry, Vol. 63, Issue 16