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Title: Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy

Abstract

The present invention covers halogenated derivatives of boronated porphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron- capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.

Inventors:
;
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1174335
Patent Number(s):
6566517
Application Number:
09/874,203
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats

Miura, Michiko, and Slatkin, Daniel N. Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy. United States: N. p., 2003. Web.
Miura, Michiko, & Slatkin, Daniel N. Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy. United States.
Miura, Michiko, and Slatkin, Daniel N. Tue . "Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy". United States. https://www.osti.gov/servlets/purl/1174335.
@article{osti_1174335,
title = {Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy},
author = {Miura, Michiko and Slatkin, Daniel N.},
abstractNote = {The present invention covers halogenated derivatives of boronated porphyrins containing multiple carborane cages having the formula ##STR1## which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron- capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2003},
month = {5}
}

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Works referenced in this record:

19F NMR Spectra and Structures of Halogenated Porphyrins
journal, July 1995


In vivo animal studies with gadolinium (III) texaphyrin as a radiation enhancer
journal, November 1999


Evaluation of carborane-containing porphyrins as tumour targeting agents for boron neutron capture therapy.
journal, July 1998


A Straightforward Synthesis of 3,4-Difluoropyrrole
journal, August 1998