Method and apparatus for fluid dispersion

Stone, Howard A.; Anna, Shelley L.; Bontoux, Nathalie; Link, Darren Roy; Weitz, David A.; Gitlin, Irina; Kumacheva, Eugenia; Garstecki, Piotr; Diluzio, Willow R.; Whitesides, George M.

Title: Method and apparatus for fluid dispersion

Abstract

A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.

Inventors:: Stone, Howard A.; Anna, Shelley L.; Bontoux, Nathalie; Link, Darren Roy; Weitz, David A.; Gitlin, Irina; Kumacheva, Eugenia; Garstecki, Piotr; Diluzio, Willow R.; Whitesides, George M.

Issue Date:: Tue Mar 24 00:00:00 EDT 2015

Research Org.:: Harvard Univ., Cambridge, MA (United States); University of Toronto, Toronto, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1174207

Patent Number(s):: 8986628

Application Number:: 13/679,190

Assignee:: President and Fellows of Harvard College (Cambridge, MA); The Governing Council of the Univ. of Toronto (Toronto, CA)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01F - MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01F - MIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
B01F2215/0431 - Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
B01F2215/045 - Numerical flow-rate values

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L3/5027 - {by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

B - PERFORMING OPERATIONS B05 - SPRAYING OR ATOMISING IN GENERAL B05B - SPRAYING APPARATUS
B05B7/0408 - {with arrangements for mixing two or more liquids}
B05B7/0416 - {with arrangements for mixing one gas and one liquid}
B05B7/0441 - {with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S516/924 - Significant dispersive or manipulative operation or step in making or stabilizing colloid system
Y10S516/927 - in situ formation of a colloid system making or stabilizing agent which chemical reaction

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T137/0324 - With control of flow by a condition or characteristic of a fluid
Y10T137/0329 - Mixing of plural fluids of diverse characteristics or conditions
Y10T137/206 - Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
Y10T137/87346 - Including mixing feature
Y10T29/49002 - Electrical device making
Y10T436/2575 - Volumetric liquid transfer

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DOE Contract Number:: FG02-00ER45852

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Nov 16

Country of Publication:: United States

Language:: English

Subject:: 42 ENGINEERING

Citation Formats


                    Stone, Howard A., Anna, Shelley L., Bontoux, Nathalie, Link, Darren Roy, Weitz, David A., Gitlin, Irina, Kumacheva, Eugenia, Garstecki, Piotr, Diluzio, Willow R., and Whitesides, George M. Method and apparatus for fluid dispersion.  United States: N. p., 2015. 
        Web.

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                    Stone, Howard A., Anna, Shelley L., Bontoux, Nathalie, Link, Darren Roy, Weitz, David A., Gitlin, Irina, Kumacheva, Eugenia, Garstecki, Piotr, Diluzio, Willow R., & Whitesides, George M. Method and apparatus for fluid dispersion.  United States.

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                    Stone, Howard A., Anna, Shelley L., Bontoux, Nathalie, Link, Darren Roy, Weitz, David A., Gitlin, Irina, Kumacheva, Eugenia, Garstecki, Piotr, Diluzio, Willow R., and Whitesides, George M. Tue .  
        "Method and apparatus for fluid dispersion".  United States.  https://www.osti.gov/servlets/purl/1174207.

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@article{osti_1174207,

  title        = {Method and apparatus for fluid dispersion},

  author       = {Stone, Howard A. and Anna, Shelley L. and Bontoux, Nathalie and Link, Darren Roy and Weitz, David A. and Gitlin, Irina and Kumacheva, Eugenia and Garstecki, Piotr and Diluzio, Willow R. and Whitesides, George M.},

  abstractNote = {A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Mar 24 00:00:00 EDT 2015},

  month        = {Tue Mar 24 00:00:00 EDT 2015}

}

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Application of advanced cytometric and molecular technologies to minimal residual disease monitoring
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High throughput screening assay systems in microscale fluidic devices
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Nature Medicine, Vol. 8, Issue 12
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Microfluidic devices for controlled viscous shearing and formation of amphiphilic vesicles
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Comparative study on sustained release of human growth hormone from semi-crystalline poly(l-lactic acid) and amorphous poly(d,l-lactic-co-glycolic acid) microspheres: morphological effect on protein release
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Insulin-loaded biodegradable PLGA microcapsules: initial burst release controlled by hydrophilic additives
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Optimization of Droplet Generation by Controlling PDMS Surface Hydrophobicity
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Hung, Lung-Hsin; Lee, Abraham P.
ASME 2004 International Mechanical Engineering Congress and Exposition, Advances in Bioengineering
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Emulsions and Techniques for Formation
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High throughput screening assay systems in microscale fluidic devices
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Title: Method and apparatus for fluid dispersion

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Quantitative DNA fiber mapping patent, December 1998

Microfabricated crossflow devices and methods patent, November 2007

Miniaturising the laboratory in emulsion droplets journal, September 2006

Stabilization of liquid nutritional products and method of making patent, October 1997

Micro-flow system for particle separation and analysis patent, August 2002

Micro/Nano Encapsulation via Electrified Coaxial Liquid Jets journal, March 2002

Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device journal, April 2001

Effective Formation of Silicone-in-Fluorocarbon-in-Water Double Emulsions: Studies on Droplet Morphology and Stability journal, September 2002

Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres journal, July 1997

Device for mixing two fluids having different temperatures patent, September 1995

Multiple emulsions comprising a hydrophobic continuous phase patent, November 1999

Interfacial Tension Driven Monodispersed Droplet Formation from Microfabricated Channel Array journal, September 2001

Apparatus and method for forming films patent, August 1999

Microfabricated crossflow devices and methods patent-application, May 2002

Solid immersion lens structures and methods for producing solid immersion lens structures patent, October 2001

Perfectly Monodisperse Microbubbling by Capillary Flow Focusing journal, December 2001

Microfabricated cell sorter for chemical and biological materials patent, April 2003

Stabilized capillary microjet and devices and methods for producing same patent, September 2000

Method and statistical micromixer for mixing at least two liquids patent, August 2005

High throughput screening assay systems in microscale fluidic devices patent, October 2003

Man-made cell-like compartments for molecular evolution journal, July 1998

Dewetting Instability during the Formation of Polymersomes from Block-Copolymer-Stabilized Double Emulsions journal, May 2006

High throughput screening assay systems in microscale fluidic devices patent, July 2001

Process for manipulating microscopic, dielectric particles and a device therefor patent, November 2000

Generation of Polymerosomes from Double-Emulsions journal, September 2005

Cross-linked water-swellable polymer particles patent, November 1977

Electrocoalesce-separators for the separation of aqueous drops from a flowing dielectric viscous liquid journal, October 2002

Focusing of microparticles in microfluidic systems patent, January 2003

Methods and apparatus for dispersing a fluent material utilizing an electron beam patent, January 1995

High throughput screening assay systems in microscale fluidic devices patent, August 1999

Solid immersion lens structures and methods for producing solid immersion lens structures patent, May 2003

Encapsulation of Bovine Serum Albumin in Temperature-Programmed“Shell-in-Shell” Structures journal, November 2003

Fuel injection nozzle and method of use patent, February 2001

Microfluidic Control Using Colloidal Devices journal, June 2002

Stabilized capillary microjet and devices and methods for producing same patent, June 2002

Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter journal, January 2003

Transdermal delivery of glucose through hairless rat skin in vitro: effect of multiple and simple emulsions journal, September 1998

Dispensing device and method for forming material patent, June 2001

Method and apparatus for fluid dispersion patent, May 2010

Electrospray ion source for mass spectroscopy patent, April 2007

Coaxial jets generated from electrified Taylor cones. Scaling laws journal, May 2003

Capillary transport device having speed and meniscus control means patent, October 1986

Controlled fission of droplet emulsion in bifurcating microfluidic channels conference, January 2003

Controlled formulation of monodisperse double emulsions in a multiple-phase microfluidic system journal, January 2005

Method and apparatus for dispersing a gas into a liquid patent, June 1990

Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream patent, September 2004

Capturing a Photoexcited Molecular Structure Through Time-Domain X-ray Absorption Fine Structure journal, April 2001

Capillary array and related methods patent, August 2003

Device and method for creating spherical particles of uniform size patent, March 2001

Liquid atomization process patent, September 2000

Electrostatic spray module patent, May 2001

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays journal, April 1999

High-throughput screening assay systems in microscale fluidic devices patent, August 2002

Secretions of proteins by encapsulated cells patent, October 2004

On the stability of ascorbic acid in emulsified systems for topical and cosmetic use journal, October 1999

Optical sorting method patent-application, August 2002

Solid immersion lens structures and methods for producing solid immersion lens structures patent, August 2003

Monodisperse Emulsion Generation via Drop Break Off in a Coflowing Stream journal, January 2000

Apparatus for particles patent, January 1989

Production of lipospheres as carriers for bioactive compounds journal, June 2002

Fluid separation device patent, March 2011

Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles journal, November 2002

In Vitro Evolution In Microfluidic Systems patent-application, April 2006

Apparatus for producing a spray of droplets of a liquid patent, May 1989

Electrostatic and hydrodynamic separation of aqueous drops in a flowing viscous oil journal, September 2002

Induction of asymmetry in vesicles patent, April 1993

In vitro evolution in microfluidic systems patent, June 2011

Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network patent-application, September 2005

Control of concentration and volume gradients in microfluidic droplet arrays for protein crystallization screening conference, January 2004

An Axisymmetric Flow-Focusing Microfluidic Device journal, April 2005

Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber patent, March 2001

Continuous manufacturing method for microspheres and apparatus
patent, January 2001

Method and apparatus for fluid dispersion
patent, December 2012

Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting
journal, January 2004

Microfabricated elastomeric valve and pump systems
patent, June 2002

Emulsions: basic principles
journal, January 1999

One-Dimensional Simulation of the Breakup of Capillary jets of Conducting Liquids. Application to E.H.D. Spraying
journal, August 1999

Quantitative DNA fiber mapping
patent, December 1998

Microfabricated crossflow devices and methods
patent, November 2007

Miniaturising the laboratory in emulsion droplets
journal, September 2006

Stabilization of liquid nutritional products and method of making
patent, October 1997

Micro-flow system for particle separation and analysis
patent, August 2002

Micro/Nano Encapsulation via Electrified Coaxial Liquid Jets
journal, March 2002

Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device
journal, April 2001

Effective Formation of Silicone-in-Fluorocarbon-in-Water Double Emulsions: Studies on Droplet Morphology and Stability
journal, September 2002

Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres
journal, July 1997

Device for mixing two fluids having different temperatures
patent, September 1995

Multiple emulsions comprising a hydrophobic continuous phase
patent, November 1999

Interfacial Tension Driven Monodispersed Droplet Formation from Microfabricated Channel Array
journal, September 2001

Apparatus and method for forming films
patent, August 1999

Microfabricated crossflow devices and methods
patent-application, May 2002

Solid immersion lens structures and methods for producing solid immersion lens structures
patent, October 2001

Perfectly Monodisperse Microbubbling by Capillary Flow Focusing
journal, December 2001

Microfabricated cell sorter for chemical and biological materials
patent, April 2003

Stabilized capillary microjet and devices and methods for producing same
patent, September 2000

Method and statistical micromixer for mixing at least two liquids
patent, August 2005

High throughput screening assay systems in microscale fluidic devices
patent, October 2003

Man-made cell-like compartments for molecular evolution
journal, July 1998

Dewetting Instability during the Formation of Polymersomes from Block-Copolymer-Stabilized Double Emulsions
journal, May 2006

High throughput screening assay systems in microscale fluidic devices
patent, July 2001

Process for manipulating microscopic, dielectric particles and a device therefor
patent, November 2000

Generation of Polymerosomes from Double-Emulsions
journal, September 2005

Cross-linked water-swellable polymer particles
patent, November 1977

Electrocoalesce-separators for the separation of aqueous drops from a flowing dielectric viscous liquid
journal, October 2002

Focusing of microparticles in microfluidic systems
patent, January 2003

Methods and apparatus for dispersing a fluent material utilizing an electron beam
patent, January 1995

High throughput screening assay systems in microscale fluidic devices
patent, August 1999

Solid immersion lens structures and methods for producing solid immersion lens structures
patent, May 2003

Encapsulation of Bovine Serum Albumin in Temperature-Programmed“Shell-in-Shell” Structures
journal, November 2003

Fuel injection nozzle and method of use
patent, February 2001

Microfluidic Control Using Colloidal Devices
journal, June 2002

Stabilized capillary microjet and devices and methods for producing same
patent, June 2002

Integrating advanced functionality in a microfabricated high-throughput fluorescent-activated cell sorter
journal, January 2003

Transdermal delivery of glucose through hairless rat skin in vitro: effect of multiple and simple emulsions
journal, September 1998

Dispensing device and method for forming material
patent, June 2001

Method and apparatus for fluid dispersion
patent, May 2010

Electrospray ion source for mass spectroscopy
patent, April 2007

Coaxial jets generated from electrified Taylor cones. Scaling laws
journal, May 2003

Capillary transport device having speed and meniscus control means
patent, October 1986

Controlled fission of droplet emulsion in bifurcating microfluidic channels
conference, January 2003

Controlled formulation of monodisperse double emulsions in a multiple-phase microfluidic system
journal, January 2005

Method and apparatus for dispersing a gas into a liquid
patent, June 1990

Microfluidic device and method for focusing, segmenting, and dispensing of a fluid stream
patent, September 2004

Capturing a Photoexcited Molecular Structure Through Time-Domain X-ray Absorption Fine Structure
journal, April 2001

Capillary array and related methods
patent, August 2003

Device and method for creating spherical particles of uniform size
patent, March 2001

Liquid atomization process
patent, September 2000

Electrostatic spray module
patent, May 2001

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays
journal, April 1999

High-throughput screening assay systems in microscale fluidic devices
patent, August 2002

Secretions of proteins by encapsulated cells
patent, October 2004

On the stability of ascorbic acid in emulsified systems for topical and cosmetic use
journal, October 1999

Optical sorting method
patent-application, August 2002

Solid immersion lens structures and methods for producing solid immersion lens structures
patent, August 2003

Monodisperse Emulsion Generation via Drop Break Off in a Coflowing Stream
journal, January 2000

Apparatus for particles
patent, January 1989

Production of lipospheres as carriers for bioactive compounds
journal, June 2002

Fluid separation device
patent, March 2011

Colloidosomes: Selectively Permeable Capsules Composed of Colloidal Particles
journal, November 2002

In Vitro Evolution In Microfluidic Systems
patent-application, April 2006

Apparatus for producing a spray of droplets of a liquid
patent, May 1989

Electrostatic and hydrodynamic separation of aqueous drops in a flowing viscous oil
journal, September 2002

Induction of asymmetry in vesicles
patent, April 1993

In vitro evolution in microfluidic systems
patent, June 2011

Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
patent-application, September 2005

Control of concentration and volume gradients in microfluidic droplet arrays for protein crystallization screening
conference, January 2004

An Axisymmetric Flow-Focusing Microfluidic Device
journal, April 2005

Device and method for fluid aeration via gas forced through a liquid within an orifice of a pressure chamber
patent, March 2001

Liquid atomization procedure
patent, June 2001

Process for producing emulsion and microcapsules and apparatus therefor
patent, September 2007

Method and device for production of components for microfabrication
patent, September 2002