Potent and selective mediators of cholesterol efflux

Bielicki, John K; Johansson, Jan

Advanced Search OptionsAdvanced Search queries use a traditional Term Search. For more info, see our FAQ.

All Fields:

Patent Title:

Abstract:

Assignee:

Inventor(s):

Patent Number:

Patent Classification (CPC):

All Classifications
A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
B25 - hand tools
B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
B30 - presses
B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
B99 - subject matter not otherwise provided for in this section
C - chemistry
C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
C04 - cements
C05 - fertilisers
C06 - explosives
C07 - organic chemistry
C08 - organic macromolecular compounds
C09 - dyes
C10 - petroleum, gas or coke industries
C11 - animal or vegetable oils, fats, fatty substances or waxes
C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
C40 - combinatorial technology
C99 - subject matter not otherwise provided for in this section
D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
D99 - subject matter not otherwise provided for in this section
E - fixed constructions
E01 - construction of roads, railways, or bridges
E02 - hydraulic engineering
E03 - water supply
E04 - building
E05 - locks
E06 - doors, windows, shutters, or roller blinds in general
E21 - earth drilling
E99 - subject matter not otherwise provided for in this section
F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
F15 - fluid-pressure actuators
F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
G99 - subject matter not otherwise provided for in this section
H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
H99 - subject matter not otherwise provided for in this section
Y - new / cross sectional technologies
Y02 - technologies or applications for mitigation or adaptation against climate change
Y04 - information or communication technologies having an impact on other technology areas
Y10 - technical subjects covered by former uspc

More Options ...

Title: Potent and selective mediators of cholesterol efflux

Abstract

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

Inventors:: Bielicki, John K; Johansson, Jan

Issue Date:: Tue Mar 24 00:00:00 EDT 2015

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1174197

Patent Number(s):: 8987192

Application Number:: 12/519,116

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Show more

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides
A61K38/16 - Peptides having more than 20 amino acids

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P29/00 - Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents
A61P3/06 - Antihyperlipidemics
A61P39/02 - Antidotes
A61P9/00 - Drugs for disorders of the cardiovascular system
A61P9/10 - for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/4703 - {Inhibitors
C07K14/775 - Apolipopeptides

Show less

DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007 Dec 13

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Bielicki, John K, and Johansson, Jan. Potent and selective mediators of cholesterol efflux.  United States: N. p., 2015. 
        Web.

Copy to clipboard


                    Bielicki, John K, & Johansson, Jan. Potent and selective mediators of cholesterol efflux.  United States.

Copy to clipboard


                    Bielicki, John K, and Johansson, Jan. Tue .  
        "Potent and selective mediators of cholesterol efflux".  United States.  https://www.osti.gov/servlets/purl/1174197.

Copy to clipboard


                    
@article{osti_1174197,

  title        = {Potent and selective mediators of cholesterol efflux},

  author       = {Bielicki, John K and Johansson, Jan},

  abstractNote = {The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Mar 24 00:00:00 EDT 2015},

  month        = {Tue Mar 24 00:00:00 EDT 2015}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Characteristics of the amino acids as components of a peptide hormone sequence
book, January 1976

Rudinger, J.; Parsons, J. A.
Peptide Hormones, p. 1-7
https://doi.org/10.1007/978-1-349-02718-7_1

Protein Folding: A Glimpse of the Holy Grail?
journal, October 1998

Berendsen, H. J. C.
Science, Vol. 282, Issue 5389, p. 642-643
https://doi.org/10.1126/science.282.5389.642

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Ngo, J. Thomas; Marks, Joe; Karplus, Martin
The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506
https://doi.org/10.1007/978-1-4684-6831-1_14

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat
journal, November 2002

Bradley, Christina Marchetti; Barrick, Doug
Journal of Molecular Biology, Vol. 324, Issue 2, p. 373-386
https://doi.org/10.1016/S0022-2836(02)00945-2

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels
journal, February 2002

Ramprasad, Mysore P.; Anantharamaiah, G. M.; Garber, David W.
Journal of Controlled Release, Vol. 79, Issue 1-3, p. 207-218
https://doi.org/10.1016/S0168-3659(01)00552-1

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity
journal, February 2004

Song, Yun Mi; Yang, Sung-Tae; Lim, Shin Saeng
Biochemical and Biophysical Research Communications, Vol. 314, Issue 2, p. 615-621
https://doi.org/10.1016/j.bbrc.2003.12.142

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus
journal, February 1992

Sparrow, James T.; Sparrow, Doris A.; Fernando, Germain
Biochemistry, Vol. 31, Issue 4, p. 1065-1068
https://doi.org/10.1021/bi00119a015

Methods and reagents for modulating cholesterol levels
patent-application, March 2004

Hayden, Michael R.; Wilson, Angela R. Brooks; Pimstone, Simon N.
US Patent Application 10/617334; 20040058869
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040058869

Helical synthetic peptides that stimulate cellular cholesterol efflux
patent-application, September 2005

Bielicki, John K.; Natarajan, Pradeep
US Patent Application 11/014187; 20050202532
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050202532

Orally administered peptides synergize statin activity
patent-application, April 2008

Fogelman, Alan M.; Anantharamaiah, Gattadahalli M.; Navab, Mohamad
US Patent Application 11/830675; 20080096815
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080096815

Compositions and methods of use for treating cardiovascular disease
patent-application, September 2008

Heinecke, Jay W.; Oram, John F.; Oda, Michael N.
US Patent Application 11/952044; 20080234192
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080234192

Similar Records in DOE Patents and OSTI.GOV collections:

Peptide mediators of cholesterol efflux

Patent Bielicki, John K.; Johansson, Jan

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
Full Text Available
Peptides having reduced toxicity that stimulate cholesterol efflux

Patent Bielicki, John K.; Johansson, Jan; Danho, Waleed

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer'smore » Disease or frontotemporal dementia. « less
Full Text Available
Peptides having reduced toxicity that stimulate cholesterol efflux

Patent Bielicki, John K.; Johansson, Jan; Danho, Waleed

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
Full Text Available
Helical synthetic peptides that stimulate cellular cholesterol efflux

Patent Bielicki, John K.; Natarajan, Pradeep

The present invention provides peptides comprising at least one amphipathic alpha helix and having an cholesterol mediating activity and a ABCA stabilization activity. The invention further provides methods of using such peptides.
Full Text Available
Peptides having reduced toxicity that stimulate cholesterol efflux

Patent Bielicki, John K.; Johansson, Jan; Danho, Waleed

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia, or inflammation; or diseases involving abnormal glucose metabolism, e.g., diabetes, metabolic syndrome; or Alzheimer'smore » Disease or frontotemporal dementia. « less
Full Text Available

Similar Records

Title: Potent and selective mediators of cholesterol efflux

Abstract

Citation Formats

Characteristics of the amino acids as components of a peptide hormone sequence book, January 1976

Protein Folding: A Glimpse of the Holy Grail? journal, October 1998

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox book, January 1994

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat journal, November 2002

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels journal, February 2002

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity journal, February 2004

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus journal, February 1992

Methods and reagents for modulating cholesterol levels patent-application, March 2004

Helical synthetic peptides that stimulate cellular cholesterol efflux patent-application, September 2005

Orally administered peptides synergize statin activity patent-application, April 2008

Compositions and methods of use for treating cardiovascular disease patent-application, September 2008

Characteristics of the amino acids as components of a peptide hormone sequence
book, January 1976

Protein Folding: A Glimpse of the Holy Grail?
journal, October 1998

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat
journal, November 2002

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels
journal, February 2002

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity
journal, February 2004

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus
journal, February 1992

Methods and reagents for modulating cholesterol levels
patent-application, March 2004

Helical synthetic peptides that stimulate cellular cholesterol efflux
patent-application, September 2005

Orally administered peptides synergize statin activity
patent-application, April 2008

Compositions and methods of use for treating cardiovascular disease
patent-application, September 2008