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Title: Potent and selective mediators of cholesterol efflux

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.
Inventors:
;
Issue Date:
OSTI Identifier:
1174197
Assignee:
The Regents of the University of California (Oakland, CA) CHO
Patent Number(s):
8,987,192
Application Number:
12/519,116
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2007 Dec 13
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

Characteristics of the amino acids as components of a peptide hormone sequence
book, January 1976

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat
journal, November 2002

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity
journal, February 2004
  • Song, Yun Mi; Yang, Sung-Tae; Lim, Shin Saeng
  • Biochemical and Biophysical Research Communications, Vol. 314, Issue 2, p. 615-621
  • DOI: 10.1016/j.bbrc.2003.12.142