Potent and selective mediators of cholesterol efflux

Bielicki, John K; Johansson, Jan

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Title: Potent and selective mediators of cholesterol efflux

Abstract

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

Inventors:: Bielicki, John K; Johansson, Jan

Issue Date:: 2015-03-24

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1174197

Patent Number(s):: 8987192

Application Number:: 12/519,116

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides
A61K38/16 - Peptides having more than 20 amino acids

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P29/00 - Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents
A61P3/06 - Antihyperlipidemics
A61P39/02 - Antidotes
A61P9/00 - Drugs for disorders of the cardiovascular system
A61P9/10 - for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/4703 - {Inhibitors
C07K14/775 - Apolipopeptides

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DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007 Dec 13

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Bielicki, John K, and Johansson, Jan. Potent and selective mediators of cholesterol efflux.  United States: N. p., 2015. 
        Web.

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                    Bielicki, John K, & Johansson, Jan. Potent and selective mediators of cholesterol efflux.  United States.

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                    Bielicki, John K, and Johansson, Jan. Tue .  
        "Potent and selective mediators of cholesterol efflux".  United States.  https://www.osti.gov/servlets/purl/1174197.

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@article{osti_1174197,

  title        = {Potent and selective mediators of cholesterol efflux},

  author       = {Bielicki, John K and Johansson, Jan},

  abstractNote = {The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {3}

}

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Works referenced in this record:

Characteristics of the amino acids as components of a peptide hormone sequence
book, January 1976

Rudinger, J.; Parsons, J. A.
Peptide Hormones, p. 1-7
https://doi.org/10.1007/978-1-349-02718-7_1

Protein Folding: A Glimpse of the Holy Grail?
journal, October 1998

Berendsen, H. J. C.
Science, Vol. 282, Issue 5389, p. 642-643
https://doi.org/10.1126/science.282.5389.642

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Ngo, J. Thomas; Marks, Joe; Karplus, Martin
The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506
https://doi.org/10.1007/978-1-4684-6831-1_14

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat
journal, November 2002

Bradley, Christina Marchetti; Barrick, Doug
Journal of Molecular Biology, Vol. 324, Issue 2, p. 373-386
https://doi.org/10.1016/S0022-2836(02)00945-2

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels
journal, February 2002

Ramprasad, Mysore P.; Anantharamaiah, G. M.; Garber, David W.
Journal of Controlled Release, Vol. 79, Issue 1-3, p. 207-218
https://doi.org/10.1016/S0168-3659(01)00552-1

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity
journal, February 2004

Song, Yun Mi; Yang, Sung-Tae; Lim, Shin Saeng
Biochemical and Biophysical Research Communications, Vol. 314, Issue 2, p. 615-621
https://doi.org/10.1016/j.bbrc.2003.12.142

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus
journal, February 1992

Sparrow, James T.; Sparrow, Doris A.; Fernando, Germain
Biochemistry, Vol. 31, Issue 4, p. 1065-1068
https://doi.org/10.1021/bi00119a015

Methods and reagents for modulating cholesterol levels
patent-application, March 2004

Hayden, Michael R.; Wilson, Angela R. Brooks; Pimstone, Simon N.
US Patent Application 10/617334; 20040058869
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040058869

Helical synthetic peptides that stimulate cellular cholesterol efflux
patent-application, September 2005

Bielicki, John K.; Natarajan, Pradeep
US Patent Application 11/014187; 20050202532
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050202532

Orally administered peptides synergize statin activity
patent-application, April 2008

Fogelman, Alan M.; Anantharamaiah, Gattadahalli M.; Navab, Mohamad
US Patent Application 11/830675; 20080096815
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080096815

Compositions and methods of use for treating cardiovascular disease
patent-application, September 2008

Heinecke, Jay W.; Oram, John F.; Oda, Michael N.
US Patent Application 11/952044; 20080234192
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080234192

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Similar Records

Title: Potent and selective mediators of cholesterol efflux

Abstract

Citation Formats

Characteristics of the amino acids as components of a peptide hormone sequence book, January 1976

Protein Folding: A Glimpse of the Holy Grail? journal, October 1998

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox book, January 1994

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat journal, November 2002

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels journal, February 2002

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity journal, February 2004

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus journal, February 1992

Methods and reagents for modulating cholesterol levels patent-application, March 2004

Helical synthetic peptides that stimulate cellular cholesterol efflux patent-application, September 2005

Orally administered peptides synergize statin activity patent-application, April 2008

Compositions and methods of use for treating cardiovascular disease patent-application, September 2008

Characteristics of the amino acids as components of a peptide hormone sequence
book, January 1976

Protein Folding: A Glimpse of the Holy Grail?
journal, October 1998

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Limits of Cooperativity in a Structurally Modular Protein: Response of the Notch Ankyrin Domain to Analogous Alanine Substitutions in Each Repeat
journal, November 2002

Sustained-delivery of an apolipoproteinE–peptidomimetic using multivesicular liposomes lowers serum cholesterol levels
journal, February 2002

Effects of l- or d-Pro incorporation into hydrophobic or hydrophilic helix face of amphipathic α-helical model peptide on structure and cell selectivity
journal, February 2004

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus
journal, February 1992

Methods and reagents for modulating cholesterol levels
patent-application, March 2004

Helical synthetic peptides that stimulate cellular cholesterol efflux
patent-application, September 2005

Orally administered peptides synergize statin activity
patent-application, April 2008

Compositions and methods of use for treating cardiovascular disease
patent-application, September 2008