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Title: Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate

A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.
Inventors:
; ; ; ; ;
Issue Date:
OSTI Identifier:
1172760
Assignee:
The Board of Trustees of the University of Illinois (Urbana, IL) CHO
Patent Number(s):
8,980,185
Application Number:
13/818,569
Contract Number:
FG02-08ER64682
Resource Relation:
Patent File Date: 2011 Aug 25
Research Org:
The Board of Trustees of the University of Illinois, Urbana, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Other works cited in this record:

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journal, February 1998

Positron Emission Tomography (PET) and Microfluidic Devices: A Breakthrough on the Microscale?
journal, March 2007
  • Audrain, Hélène
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journal, February 2010
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  • DOI: 10.2967/jnumed.109.065946

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journal, March 2006

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journal, September 2008

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journal, January 2008
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Poly(dimethylsiloxane) as a Material for Fabricating Microfluidic Devices
journal, April 2002
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  • DOI: 10.1021/ar010110q

Molecular imaging with copper-64
journal, November 2004

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